Highlight• In patients on dialysis, cinacalcet reduced the rate of bone fracture by 16% to 29%, after accounting for patient characteristics and other factors.

Bone fractures are common and potentially deadly in patients receiving dialysis.

Newswise — Washington, DC (December 11, 2014) — A drug that mimics calcium and lowers parathyroid levels may help prevent bone fractures in patients with kidney failure who are on dialysis, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Patients with kidney failure who are undergoing dialysis have an increased risk of bone fractures, and the risk of dying after a hip fracture in such a patient is double that of the general population. Unfortunately, none of the approved drugs for fracture prevention in osteoporosis in the general population are approved for use in patients on dialysis, and some are actually contraindicated.

Sharon Moe, MD (Indiana University School of Medicine and Roudebush Veterans Administration Medical Center) and her colleagues conducted a study to see whether cinacalet, a drug that lowers parathyroid hormone (PTH), can reduce the risk of fractures in patients receiving dialysis. These patients have elevated PTH levels due to problems with the way the body handles calcium when the kidneys are dysfunctional. In animals, lowering the level of PTH improves bone structure and reduces fractures.

The investigators conducted a planned secondary analysis of the EVOLVE trial, the largest study in hemodialysis patients to date. This study compared cinacalcet vs. placebo, on a background of standard of care. Clinical fractures were observed in 255 of 1935 (13.2%) patients randomized to placebo and 238 of 1948 (12.2%) patients randomized to cinacalcet. While cinacalcet did not reduce the rate of clinical fractures in unadjusted analyses, it had a protective effect against fractures after the researchers accounted for differences in patient characteristics and events that prompted patients to discontinue treatment.

“Our results showed a reduction in fracture risk by 16% to 29% in the patients receiving cinacalcet when adjusted for other fracture risk factors like age,” said Dr. Moe.

Study co-authors include Safa Abdalla, Glenn M. Chertow, Patrick S. Parfrey, Geoffrey A.Block, Ricardo Correa-Rotter, Jürgen Floege, Charles A. Herzog, Gerard M. London,Kenneth W. Mahaffey, David C. Wheeler, Bastian Dehmel, William G. Goodman, andTilman B. Drüeke, for the Evaluation of Cinacalcet HCl Therapy to Lower CardiovascularEvents (EVOLVE) Trial Investigators.

Disclosures: The study was sponsored by Amgen, and several of the authors report financial disclosures in the form of grants or consulting fees from Amgen. Two authors are employed by Amgen.

The article, entitled “Effects of Cinacalcet on Fracture Events in Patients Receiving Hemodialysis: The EVOLVE Trial,” will appear online at http://jasn.asnjournals.org/ on December 11, 2014. The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 15,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

# # #

Register for reporter access to contact details

Journal of the American Society of Nephrology