Laughing gas helpful for labor pain, safe for baby, but ultimately most women switched to an epidural, study shows 

Newswise — ORLANDO, Fla. – Women report being very satisfied with nitrous oxide (laughing gas) to manage labor pain, experiencing no adverse side effects to the baby, although over half of the women ultimately opted for an epidural or other pain management technique, suggests a study being presented at the ANESTHESIOLOGY® 2019 annual meeting.

“Our research is one of the first large retrospective studies done in the U.S., in five large university hospitals, on the use of nitrous oxide in the labor and delivery unit,” said Barbara Orlando, M.D, one of the lead authors of the study and assistant professor of anesthesiology, perioperative and pain medicine at the Icahn School of Medicine at Mount Sinai, New York. “Although nitrous oxide did not prevent women in labor from requesting other pain management options like an epidural, we received positive feedback from patients who said they like laughing gas as an option to manage their pain.”

There are a variety of options available for women to manage labor pain, ranging from epidurals and medications delivered intravenously, to complementary methods including massage, deep breathing and nitrous oxide. 

Nitrous oxide is more commonly used in Europe and Australia to manage labor pain, but has recently gained popularity in the U.S. It is an inhaled anesthetic gas that may help reduce anxiety and make patients less aware of pain, but does not eliminate it. Conversely, epidural anesthesia is the most common type of pain relief used during labor and blocks pain in the lower part of the body, allowing the laboring mother to be awake and alert throughout delivery. 

Researchers reviewed the medical records of 1,958 women who used nitrous oxide during labor between March 2016 and March 2018. The average age of the patients was 28 years old. Researchers collected: patient demographics; patient satisfaction; conversion rate to alternate pain management options, including epidurals; and Apgar score, which ranges from 0 to 10 (7 to 10 is considered reassuring) and is used to assess a newborn’s overall condition and health 1 minute and 5 minutes after birth. The authors note only 850 patients included in the study had patient satisfaction information available.  

The mean patient satisfaction rate for nitrous oxide use was 7.4 (on a scale from 0 to 10, with 10 being high). Ultimately, 68.9% of women who used nitrous oxide switched to another pain management technique, with the majority (92%) opting for an epidural. Nitrous oxide was found to be safe for the newborns, whose Apgar scores averaged 8 and 9 at 1 and 5 minutes, respectively. 

“Nitrous oxide is easy for patients to use, relatively inexpensive, and will attract more patients looking for a birthing center, or more homelike type of delivery experience,” said Dr. Orlando.  “The high patient satisfaction rate and safety profile that we found should motivate other institutions nationwide to offer nitrous oxide as a pain management option to women in labor.”


Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 53,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves. 


For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at To learn more about the role physician anesthesiologists play in ensuring patient safety, visit Join the ANESTHESIOLOGY® 2019 social conversation today. Like ASA on Facebook, follow ASALifeline on Twitter and use the hashtag #ANES19.


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