Are Organ Transplant Recipients at Greater Risk of Death from COVID-19?

Michigan Medicine - University of Michigan

Newswise — ANN ARBOR, Mich. - A new study, published in Transplantation, finds that risk of death from COVID-19 in organ transplant recipients may be based upon how the patient was treated.

“Using data from the COVID-19 Rapid Response Registry, we examined COVID-19 positive adult solid organ transplant recipients and non-transplant patients that were matched to them on age, race and whether they were admitted at the hospital or seen at an outpatient facility,” says lead author of the study, Pratima Sharma, M.D., an associate professor of medicine and a transplant hepatologist at Michigan Medicine.

Sharma says the demographics of patients included in the study were also consistent with COVID-19 patient trends throughout the state of Michigan.

“Black Michiganders represent 15% of the total population in the state and account for 42% of COVID-19-related deaths, compared to white Michiganders who represent 75% of the population in the state and 26% of deaths from COVID-19,” she says.

“These statistics are also valid for solid organ transplant recipients, and while Black patients account for one tenth of all organ transplant recipients in our University of Michigan Transplant Center, they represented two-thirds of the COVID-19 positive organ transplant recipients group in this study,” she adds. “These results highlight the racial inequities that have overwhelmed the United States health care system during this pandemic.”

The research team found that disease severity and intubation rates were similar among both solid organ transplant recipients and non-transplant patients, but organ transplant recipients needed more renal replacement therapy, which takes over functioning for the kidneys when they are failing.

While death due to severity of the virus was similar in both groups, the use of hydroxychloroquine treatment was associated with higher death rates among the organ transplant recipients.

“In fact, we found that the treatment of hydroxychloroquine among organ transplant recipients was associated with ten-fold higher risk of death compared to not using the treatment among the recipients,” Sharma says.

Sharma and her colleagues hope that these findings encourage further scrutiny of hydroxychloroquine use in organ transplant recipients infected with COVID-19.

The study research team led by Sharma includes Michigan Medicine researchers from five divisions/units: Vincent Chen, M.D., Vaiibhav Patel, M.D., Michael Combs, M.D., Silas Norman, M.D., Puneet Garg, M.D., Monica Colvin, M.D., Jonathan Golob, M.D., Ph.D., Monica Doshi, M.D., and Keith Aaronson, M.D., M.S., of the Department of Internal Medicine; Christopher Sonnenday, M.D., MHS, of the Department of Surgery; Christopher Fung, M.D., of the Department of Emergency Medicine; Emily Somers, Ph.D., of the U-M School of Public Health; and Jonathan Troost, Ph.D., of the Michigan Institute for Clinical and Health Research.

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 3837
Newswise: Models show how COVID-19 cuts a neighborhood path
Released: 29-Oct-2020 3:45 PM EDT
Models show how COVID-19 cuts a neighborhood path
University of Washington

A research team led by UC Irvine and the University of Washington has created a new model of how the coronavirus can spread through a community. The model factors in network exposure — whom one interacts with — and demographics to simulate at a more detailed level both where and how quickly the coronavirus could spread through Seattle and 18 other major cities.

Released: 29-Oct-2020 2:55 PM EDT
Lung scans for stroke patients could provide earlier COVID-19 detection
American Heart Association (AHA)

Computed tomography angiogram (CTA) scans may offer fast and early detection of COVID-19 in acute ischemic stroke (AIS) patients, according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association.

Released: 29-Oct-2020 2:25 PM EDT
Contrary to the viral rumors on social media, Dr. Fauci did not write a paper on how masks caused mass deaths in the 1918 flu pandemic
Newswise

Posts are being shared on social media attempting to negate the use of masks as protective devices during the pandemic. These claims are false. Fauci did not blame mask use for any deaths that occurred during the 1918 Spanish flu.

Newswise: How Does the Environment Impact COVID-19?
Released: 29-Oct-2020 2:10 PM EDT
How Does the Environment Impact COVID-19?
Homeland Security's Science And Technology Directorate

S&T NBACC research finds that sunlight is the strongest environmental factor that inactivates COVID-19.

Released: 29-Oct-2020 1:25 PM EDT
The Lancet Healthy Longevity: Residential context important factor in risk of COVID-19 mortality among older adults, Stockholm study suggests
Lancet

New study of older adults (aged 70 or over) in Stockholm, Sweden, suggests older people living in care homes had higher COVID-19 mortality risk than those living in single houses or apartment buildings.

Released: 29-Oct-2020 1:10 PM EDT
Study measures effectiveness of different face mask materials when coughing
University of Cambridge

A team of researchers have tested everything from t-shirts and socks to jeans and vacuum bags to determine what type of mask material is most effective at trapping the ultrafine particles which may contain viruses such as SARS-CoV-2, the virus which causes COVID-19.

Newswise: Hide and seek: Understanding how COVID-19 evades detection in a human cell
Released: 29-Oct-2020 12:35 PM EDT
Hide and seek: Understanding how COVID-19 evades detection in a human cell
Argonne National Laboratory

Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body.

Released: 29-Oct-2020 12:20 PM EDT
Two million lost health coverage, thousands died prematurely in Trump's first 3 years
Physicians For A National Health Program

A new analysis of federal surveys on health insurance coverage concludes that the number of uninsured Americans increased by about 2.3 million between 2016 and 2019.

Released: 29-Oct-2020 12:05 PM EDT
How people would choose who gets scarce COVID-19 treatment
Ohio State University

As COVID-19 cases begin climbing again in the United States, the possibility arises of a grim moral dilemma: Which patients should be prioritized if medical resources are scarce?

Newswise: 247273_web.jpg
Released: 29-Oct-2020 12:00 PM EDT
Escaping the 'Era of Pandemics': experts warn worse crises to come; offer options to reduce risk
The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES)

Future pandemics will emerge more often, spread more rapidly, do more damage to the world economy and kill more people than COVID-19 unless there is a transformative change in the global approach to dealing with infectious diseases, warns a major new report on biodiversity and pandemics by 22 leading experts from around the world.


Showing results

110 of 3837

close
1.29488