American Thoracic Society (ATS)

Asthma May Not Be a Significant Risk Factor for Severe COVID-19 or COVID-Related Intubation

Newswise — August 31, 2020─ A new research letter published online in the Annals of the American Thoracic Society examines whether asthma is a significant risk factor for developing COVID-19 that is severe enough to warrant hospitalization and intubation.  According to the Centers for Disease Control and Prevention, individuals with asthma are at higher risk for hospitalization and other severe effects from COVID-19, similar to the elevated risk from such health conditions as obesity, hypertension and diabetes.

In “Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor?,” Fernando Holguin, MD, MPH, and co-authors compared the prevalence of asthma among patients hospitalized for COVID-19, as reported in 15 peer-reviewed studies, with that of the corresponding population’s asthma prevalence.  They also correlated the study’s asthma prevalence with the four-year average asthma prevalence in influenza hospitalizations in the United States. In addition, they analyzed the medical records of 436 COVID-19 patients admitted to the University of Colorado Hospital to evaluate the likelihood that patients with asthma would be intubated more often than patients without asthma.

“The CDC places people with asthma at higher risk for COVID-related hospitalization,” said Dr. Holguin, professor, Asthma Clinical & Research Program, Pulmonary Division, University of Colorado Anschutz Medical Campus.  “However, many international studies show low numbers of asthmatics among hospitalized COVID-19 patients.  These findings challenge the assumption about asthma as a risk factor.”

The researchers performed a focused review of English-language scientific literature in order to identify studies reporting asthma prevalence among patients hospitalized for COVID-19 infection.  Three independent reviewers agreed on 15 studies to include in the analysis.  Using local data from hospitalized COVID-19 patients, they performed a statistical analysis to determine the relationship between asthma status and intubation, once they took into account patients’ age, gender and body mass index (BMI).

The authors stated, “We found that the proportion of asthmatics among hospitalized patients with COVID-19 is relatively similar to that of each study site’s population asthma prevalence.  This finding is in stark contrast to influenza, in which asthmatics make up more than 20 percent of those hospitalized in the United States.”

“Using data from our hospital, we also observed that among COVID-19 patients, those with asthma, which had a 12 percent prevalence rate, did not seem to be more likely to be intubated than non-asthmatics,” they added.

Dr. Holguin and colleagues theorize that the corticosteroid inhalers many people with asthma use make it more difficult for coronaviruses to enter their airways. Specifically, these individuals may have lower levels of expression of ACE2, a protein that binds to SARS-CoV-2, the virus caused by COVID-19.  People with asthma that is related to allergies may also have lower expression of ACE2, whether or not they use corticosteroids.

“The contribution of ACE2 receptor expression levels to COVID-19 susceptibility is still unclear, however, it should certainly be further investigated,” said Dr. Holguin.

Dr. Holguin adds that the asthma-COVID-intubation risk relationship should be studied further.

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 3765
Released: 23-Oct-2020 4:55 PM EDT
Woman recovering from COVID-19 shares experience as monoclonal antibody clinical trial participant
University of Texas Health Science Center at Houston

When Christina Loville tested positive for the coronavirus, she was terrified. She decided to channel her fear into researching COVID-19 treatments, where she discovered a local clinical trial led by experts at The University of Texas Health Science Center at Houston (UTHealth).

Released: 23-Oct-2020 4:30 PM EDT
"Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29, 3PM EDT
Newswise

"Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29, 3PM EDT

Released: 23-Oct-2020 1:50 PM EDT
Are we really “rounding the corner" when it comes the coronavirus pandemic?
Newswise

“We’re rounding the turn,” Trump said during the debate. This implies a meaningful improvement. We rate this claim as false. On that very same day the U.S. recorded 77,000 new cases, according to NBC News. This tops the previous high that had been set in July. We may be learning to "live with it," as Trump mentioned, but this is not an improvement.

Newswise: 246719_web.jpg
Released: 23-Oct-2020 12:50 PM EDT
NRL researchers evaluate ultraviolet sources, combat COVID-19
United States Naval Research Laboratory

U.S. Naval Research Laboratory researchers evaluated commercial ultraviolet (UV) sources for viral disinfection to combat COVID-19 on land and at sea, and established a dedicated UV characterization lab in five days to ensure safe introduction and effective operation of UV sources across the Fleet.

Released: 23-Oct-2020 12:05 PM EDT
COVID-19 anxiety linked to body image issues
Anglia Ruskin University

A new study has found that anxiety and stress directly linked to COVID-19 could be causing a number of body image issues amongst women and men.

Newswise: 246747_web.jpg
Released: 23-Oct-2020 11:45 AM EDT
Eliminating COVID-19: What the world can learn from NZ and Taiwan
University of Otago

Both Taiwan and New Zealand have successfully eliminated COVID-19 with world-leading pandemic responses. By taking a particularly proactive approach, Taiwan's response was probably the most effective and least disruptive of any country's, researchers say.

Released: 23-Oct-2020 11:00 AM EDT
Healthcare's earthquake: Lessons from COVID-19
Beth Israel Deaconess Medical Center

The COVID-19 pandemic has fundamentally disrupted U.S. healthcare organizations.

Released: 23-Oct-2020 10:50 AM EDT
COVID-19 lockdown reduced mental health, sleep, exercise
Pennington Biomedical Research Center

A first-of-its-kind global survey shows the initial phase of the COVID-19 lockdown dramatically altered our personal habits, largely for the worse.

Released: 23-Oct-2020 10:45 AM EDT
New Data on Increasing Cloth Mask Effectiveness
Society for Risk Analysis (SRA)

A new study published in Risk Analysis, “Reinventing cloth masks in the face of pandemics,” by Stephen Salter, P.Eng., describes how Effective Fiber Mask Programs (EFMPs) can help communities find a balance between the economy and curbing community spread.


Showing results

110 of 3765

close
1.21604