Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)

Comparison of COVID-19 outcomes between racial groups in the COViMS registry

Research Alert

Newswise — Background: Risk factors previously identified for worse outcomes with SARS-CoV-2 infections include older age, male sex and specific comorbid conditions. An increased risk for poorer COVID-19 outcomes in people with multiple sclerosis (MS) are similar to the general population, but less is known about outcomes in minority groups with MS.

Objectives: To evaluate differences in outcomes of SARS-CoV-2 infection in non-Hispanic White and Black persons with multiple sclerosis.

Methods: COViMS is a North American registry for health care providers to report persons with MS who are infected with SARS-CoV-2, the virus that causes COVID-19 (cases). Cases are reported after 7 days and when the outcome of infection is reasonably certain. MS and clinically isolated syndrome cases were categorized using the Center for Disease Control and Prevention races (non-Hispanic Whites, and Black). Comorbidities related to COVID-19 outcomes were collected. Clinical outcomes examined were mortality alone, mortality and/or admissions to the intensive care unit (ICU) and mortality, ICU admissions and/or hospitalization. Age-adjusted mortality rates as of August 3, 2020 and 95% confidence intervals (CI) were calculated. Multivariable logistic regression was used to assess adjusted differences between races using odds ratios (OR) and 95% CIs. Covariates included sex, age, smoking (current, past, never), MS clinical course (relapsing, progressive), disease duration, ambulation (fully ambulatory, walks with assistance, non-ambulatory), individual comorbidities (cardiovascular disease, cerebrovascular disease, chronic kidney disease, chronic lung disease, diabetes, hypertension, morbid obesity), and disease modifying therapy use (yes vs no).

Results: Of 734 patients reported, 421 (57.4%) Whites, and 194 (26.5%) Black patients were reported. Black cases were more likely to be younger (p=0.002), never smokers (p=0.002), have shorter MS duration (p<0.001), a relapsing MS course (p=0.03) and have comorbidities (p<0.001) compared to Whites. A higher proportion of Black patients had hypertension (40.2% vs 19.5%, p<0.001), and morbid obesity (17.0% vs 9.5%, p=0.007). Mortality rates increased with age and were not statistically different between Whites and Blacks (p=0.156). Black race was associated with increased odds of mortality and/or ICU admission (OR 3.8 [95%CI: 1.60, 8.96], p=0.002) and mortality, ICU admission and/or hospitalization (OR 2.0 [95%CI: 1.14, 3.54], p=0.016) after adjustment for covariates.

Conclusions: Within the COViMS registry, Black MS patients were younger and more likely to have comorbidities than White MS patients. Black MS patients had an increased risk for poorer outcomes compared to Whites even after adjusting for comorbidities at the time of COVID-19.

Presenter:Amber Salter, Washington University School of Medicine, Department of Biostatistics, Biostatistics, 660 S. Euclid Ave, 63110, St. Louis, US

Filters close

Showing results

110 of 3733
Released: 21-Oct-2020 3:40 PM EDT
Pastoral care shown to support older people at risk from COVID-19
Staffordshire University

Volunteers from the Catholic Church in Brazil helped to mitigate the impact of COVID-19 among the elderly, a new study shows.

Newswise: UH Implements Virtual Waiting Room for Patients During COVID-19 Pandemic
Released: 21-Oct-2020 3:30 PM EDT
UH Implements Virtual Waiting Room for Patients During COVID-19 Pandemic
University Hospitals Cleveland Medical Center

UH has implemented PatientTrak, a virtual waiting room that enables the patient to communicate effectively with staff so they can arrive at their appointment on time while avoiding an in-person waiting room.

Released: 21-Oct-2020 3:15 PM EDT
Mass screening method could slash COVID-19 testing costs, trial finds
University of Edinburgh

Using a new mathematical approach to screen large groups for Covid-19 could be around 20 times cheaper than individual testing, a study suggests.

Newswise: 246543_web.jpg
Released: 21-Oct-2020 2:45 PM EDT
Observed COVID-19 variability may have underlying molecular sources
University of California, Riverside

People have different susceptibilities to SARS-CoV-2, the virus behind the COVID-19 pandemic, and develop varying degrees of fever, fatigue, and breathing problems -- common symptoms of the illness. What might explain this variation?

Released: 21-Oct-2020 2:10 PM EDT
Hospitals Leaned Toward Strict COVID-19 NICU Policies Despite Low Prevalence of Infection, New Study Finds
George Washington University

Two studies examining the impact of COVID-19 on neonatal intensive care units (NICUs) found the prevalence of COVID-19 in NICU infants is low, yet many hospitals at the start of the pandemic put in place strict parental visitation policies and scaled back NICU services such as lactation support and therapy.

Newswise: Tracking the SARS-CoV-2 Virus with Genome Sequencing
Released: 21-Oct-2020 2:05 PM EDT
Tracking the SARS-CoV-2 Virus with Genome Sequencing
University of North Carolina School of Medicine

Dirk Dittmer, PhD, professor of microbiology and immunology at the UNC School of Medicine, is tracking the virus that causes COVID-19 by sequencing the genome of virus samples collected from diagnostic testing. Using next generation sequencing on SARS-CoV-2 will help accurately diagnose the novel coronavirus, identify mutations and track its history.

Released: 21-Oct-2020 12:55 PM EDT
Study assessing how early childhood educators spend time away from students
University of Nebraska-Lincoln

Much attention is paid to the work early childhood teachers do in the classroom, but their tasks away from their students can be just as essential to children’s learning and development.

Released: 21-Oct-2020 12:50 PM EDT
Rutgers Pediatricians Sound Alarm on Decreased Flu Vaccinations, Immunizations for Children
Rutgers University-New Brunswick

Two Rutgers New Jersey Medical School pediatricians discuss the importance of keeping children and adults up to date with immunizations during the coronavirus crisis.

Released: 21-Oct-2020 11:35 AM EDT
Trump's claim that House Speaker Nancy Pelosi is to blame for the stalled COVID-19 stimulus legislation is not accurate

President Donald Trump has repeatedly blamed the U.S. House Speaker Nancy Pelosi for "not caring about Americans" since she would not agree to his terms for COVID-19 relief aid. We rate these claims as mostly false because they are misleading. According to the New York Times, Senator Mitch McConnell, Republican of Kentucky and the majority leader, told Republican senators privately on Tuesday that he has advised the White House not to strike a deal with Speaker Nancy Pelosi on a new stimulus bill before Election Day.

Showing results

110 of 3733