Coronavirus' Binding Action May Also Cause Kidney Damage and Infertility; Researchers Consider Potential Treatment Paths

Blocking ACE2 binding action could reveal therapeutic target for SARS-CoV-2
American Physiological Society (APS)
26-Mar-2020 8:00 AM EDT, by American Physiological Society (APS)

Research Alert

Article title: COVID-19 infection and mortality - A physiologist's perspective enlightening clinical features and plausible interventional strategies

Authors: Zaid A. Abassi, Karl Skorecki, Samuel Noam Heyman, Safa Kinaneh, Zaher Armaly

From the authors: "Cleavage of the S-glycoprotein by furin and its binding to ACE2-expressing cells in the lung, kidney, heart, intestine and testis are key steps in the zoonotic SARS-CoV-2 transmission. Upregulation of ACE2 and furin in cardiovascular and metabolic disease states, especially in the presence of ACE-i/ARBS/MR blockers or NSAIDs may sensitize these patients to the deleterious impact of SARS-CoV-2. Furthermore, it is appealing to assume that inhibition of furin, essential for viral intracellular translocation, or blocking the viral anchoring capability of ACE2, might be potential treatment options in combating this new formidable threat to the health and well-being of the human civilization."

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110 of 2011
Released: 29-May-2020 11:55 PM EDT
Heart surgery stalled as COVID-19 spread
University of Ottawa

As the novel coronavirus spread across the globe in early 2020, hospitals worldwide scaled back medical procedures, including life-saving heart surgery, to deal with the emerging threat of COVID-19.

Released: 29-May-2020 11:30 PM EDT
UCLA AASC & FSPH launch COVID-19 Multilingual Resource Hub to support safety for diverse communities
UCLA Fielding School of Public Health

UCLA Asian American Studies Center and the UCLA Fielding School of Public Health COVID-19 Multilingual Resource Hub to support safety for diverse communities; partnership develops resources for COVID-19 response

Newswise: UTEP Study Examines COVID-19 Stress, Coping Strategies, and Well-Being
Released: 29-May-2020 6:15 PM EDT
UTEP Study Examines COVID-19 Stress, Coping Strategies, and Well-Being
University of Texas at El Paso

Emre Umucu, Ph.D., assistant professor of rehabilitation counseling at The University of Texas at El Paso, and Beatrice Lee, an incoming rehabilitation counseling faculty member, examined the perceived stress levels and coping mechanisms related to COVID-19, and how coping affects well-being in people with self-reported chronic conditions and disabilities.

Newswise: 233197_web.jpg
Released: 29-May-2020 4:55 PM EDT
CT findings of coronavirus disease (COVID-19) in children 'often negative'
American Roentgen Ray Society (ARRS)

An investigation published open-access in the American Journal of Roentgenology (AJR) revealed a high frequency of negative chest CT findings among pediatric patients with laboratory-confirmed coronavirus disease (COVID-19), while also suggesting that bilateral, lower lobe-predominant ground-glass opacities (GGOs) are common in the subset of patients with positive CT findings.

Newswise: 233198_web.jpg
Released: 29-May-2020 4:40 PM EDT
Modelling predicts COVID-19 resurgence if physical distancing relaxed
University of Guelph

If physical distancing measures in Ontario are relaxed too much or too quickly, the province could see hospitals overwhelmed with COVID-19 patients as well as exponential growth in deaths, concludes new research involving a University of Guelph infectious disease modeller.

Released: 29-May-2020 3:35 PM EDT
Using Wastewater to Track, Contain SARS-CoV-2
SUNY College of Environmental Science and Forestry

Researchers took a novel approach to tracking the virus that causes COVID-19 that promises to be cost effective and ensure privacy by using a method that surveils for the virus in a local's untreated wastewater facilities.

Newswise: fimmu-11-01208-g001.jpg
Released: 29-May-2020 2:40 PM EDT
Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response
Sbarro Health Research Organization (SHRO)

Researchers predict the Human Leukocyte Antigen (HLA) gene has a key role in shaping immune response to COVID.

Released: 29-May-2020 1:40 PM EDT
Study finds surge in hydroxychloroquine/chloroquine prescriptions during COVID-19
Brigham and Women’s Hospital

A new study by investigators from Brigham and Women's Hospital examines changes in prescription patterns in the United States during the COVID-19 pandemic.


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