Expert Pitch
American Federation for Aging Research (AFAR)

Experts: Geroscience Approach May Lessen Severity of COVID-19, Bolster Older Patients’ Response to Diseases

Recording now available of webinar featuring four leading geroscience experts discussing how targeting the biology of aging may boost immune response to help older adults fight infections, diseases

Newswise — March 26, 2020 (New York, NY) – As the nation and world respond to the growing COVID-19 pandemic, a panel of leading aging research experts, convened by the American Federation for Aging Research (AFAR), posed that targeting the biology of aging through promising therapeutics could bolster the medical response to COVID-19 and other viruses that are devastating older patients.

A recording of the webinar featuring the four experts is now available for streaming. Presenter slides are also available.

“The field of aging research has developed a range of promising drug interventions, or gerotherapeutics, that may modulate response to viral infection in older adults by targeting not only immune decline and inflammation, but by increasing whole-body resiliency to severe illness,” says Nir Barzilai, MD, AFAR Scientific Director and Director of the Institute for Aging Research at Albert Einstein College of Medicine. 

“We urge regulatory bodies to expedite the evaluation of these gerotherapeutics for testing in older adults exposed to COVID-19. This is an important approach not only for the current COVID-19 pandemic, but for future pandemics as well.”

The 90-minute webinar, COVID-19: Can the Science of Aging Move Us Forward?, explored how targeting the biology of aging that is the greatest risk factor for all major diseases—including heart disease, cancer, stroke, pneumonia, diabetes, and others—can help older adults live healthier and longer. In countries from China to Italy to the United States, older adults have by far been at greatest risk for hospitalizations, intensive care unit use, and death as a result of COVID-19.

The webinar also highlighted two promising gerotherapeutics: the common diabetes drug metformin and mTOR inhibitors such as rapamycin. In addition to Barzilai, the webinar featured: 

  • Sean Leng, MD, PhD - Professor of Medicine, Johns Hopkins University School of Medicine and 2006 AFAR Beeson Scholar, who provided an overview of statistics and the geroscience approach to COVID-19 and older adults
  • George Kuchel, MD, FRCP, AGSF - Director and Chief of Geriatric Medicine, UConn Center on Aging, on research related to the vulnerability of older adults to COVID-19
  • Joan Mannick, MD - Co-Founder and Chief Medical Officer, resTORbio, who presented on the results of clinical trials involving resTORbio’s lead product candidate, RTB101, which inhibits the activity of a protein complex called target of rapamycin complex 1, or TORC1, an evolutionarily conserved pathway that contributes to the decline in function of multiple aging organ systems.

RTB101 is an example of the gerotherapeutics, or “geroprotectors,” being developed by biotech and pharmaceutical companies to target what are known as the “hallmarks of aging,” such as immune dysfunction and inflammation. 

To learn more, view the full webinar. and download presenter slides here.


About AFAR. The American Federation for Aging Research (AFAR) is a national non-profit organization that supports and advances pioneering biomedical research that is revolutionizing how we live healthier and longer. For nearly four decades, AFAR has served as the field’s talent incubator, providing more than $181 million to more than 4,200 investigators at premier research institutions nationwide. A trusted leader and strategist, AFAR also works with public and private funders to steer high quality grant programs and interdisciplinary research networks. 

AFAR-funded researchers are finding that modifying basic cellular processes can delay—or even prevent—many chronic diseases, often at the same time. They are discovering that it is never too late—or too early—to improve health. This groundbreaking science is paving the way for innovative new therapies that promise to improve and extend our quality of life—at any age. Learn more at or follow AFARorg on Twitter and Facebook.

Filters close

Showing results

110 of 5575
Released: 6-May-2021 4:20 PM EDT
How to Win Over Vaccine Skeptics: Live Expert Panel for May 20, 3pm ET

How to Win Over Vaccine Skeptics: Live Expert Panel for May 20, 3pm ET

Released: 6-May-2021 2:15 PM EDT
Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19
Front Line COVID-19 Critical Care Alliance (FLCCC Alliance)

After the Most Comprehensive Review to Date, a Panel of Leading Medical Experts Conclude that Ivermectin Should be Systematically and Globally Adopted for the Prevention and Treatment of COVID-19

Released: 6-May-2021 2:10 PM EDT
Mayo Clinic


Newswise: CSUCIVaxClinic4-29-21.JPG
Released: 6-May-2021 2:05 PM EDT
CSU Expands Vaccine Availability with New Partnerships
California State University (CSU) Chancellor's Office

Many CSU campuses now offer even more options for students and employees to get their COVID-19 shots, thanks to unique partnerships with national pharmacies and local hospitals.

Released: 6-May-2021 1:50 PM EDT
الأطفال أيضًا يواجهون آثارًا طويلة المدى لفيروس كورونا المستجد (كوفيد-19)
Mayo Clinic

مدينة روتشستر، ولاية مينيسوتا ― تؤثر الآثار طويلة المدى لعدوى فيروس كورونا المستجد (كوفيد-19) على صحة بعض الأطفال والمراهقين، وكذا البالغين. في حين أن معظم الأطفال المصابين بعدوى فيروس كورونا المستجد (كوفيد-19) يعانون من أعراض خفيفة أو لا تظهر عليهم أي أعراض على الإطلاق، فإن أي شخص أصيب بفيروس كورونا المستجد (كوفيد-19) - حتى لو كان المرض خفيفًا أو لم تظهر عليه أعراض - قد يُصاب بآثار طويلة المدى.

Released: 6-May-2021 1:35 PM EDT
As crianças também enfrentam efeitos de longo prazo da COVID-19
Mayo Clinic

Os efeitos de longo prazo da infecção por COVID-19 estão afetando a saúde de algumas crianças e adolescentes, bem como de adultos. Embora a maioria das crianças com infecção por COVID-19 tenha sintomas leves ou nenhum sintoma, qualquer pessoa que teve COVID-19, mesmo se leve ou sem sintomas, pode ter efeitos de longo prazo.

Newswise: Retired Nurse Returns to the Front Lines
Released: 6-May-2021 1:25 PM EDT
Retired Nurse Returns to the Front Lines
Rush University Medical Center

During the COVID-19 pandemic, Martha Kuhr, RN, came out of retirement to care for some of Rush University Medical Center's most severe COVID-19 patients in the CVICU.

Released: 6-May-2021 12:40 PM EDT
Achieving high COVID-19 vaccine coverage levels by summer can prevent millions of cases
CUNY Graduate School of Public Health and Health Policy

With around 30 percent of the U.S. population now fully vaccinated, the rate of daily vaccinations has started to slow, raising concerns that greater efforts and investments may be needed to reach higher coverage levels.

Released: 6-May-2021 12:30 PM EDT
Los niños también enfrentan los efectos a largo plazo de la COVID-19
Mayo Clinic

Los efectos a largo plazo de la infección por COVID-19 están repercutiendo en la salud de algunos niños y adolescentes, además de los adultos. Si bien la mayoría de los niños con infección por COVID-19 tienen síntomas leves o no tienen síntomas en absoluto, cualquier persona que haya tenido COVID-19 (incluso si la enfermedad fue leve o no tuvieron síntomas) puede tener efectos a largo plazo.

Showing results

110 of 5575