High risk of deep vein thrombosis and pulmonary embolism in patients with COVID-19

Systematic review of the worldwide published data on "Venous thromboembolism (VTE) in COVID-19 patients"

Newswise — (Vienna, 01 October 2020) In a systematic review of the worldwide published data on "Venous thromboembolism (VTE) in COVID-19 patients", Cihan Ay, Stephan Nopp, and Florian Moik from the Department of Medicine I, Clinical Division of Haematology and Haemostaseology, now for the first time, provide an in-depth analysis on the risk of VTE in patients hospitalised for COVID-19. While hospitalized patients at general wards have a VTE risk between 5 and 11%, the risk of developing deep vein thrombosis or pulmonary embolism in critically ill patients is 18 to 28%.

"From the beginning of the COVID-19 pandemic, studies reported an increased rate of thrombosis and pulmonary embolism in patients with COVID-19. On the basis of these reports, but without robust evidence from controlled interventional studies, global treatment strategies were developed, recommending more intense thromboprophylaxis strategies. Our study now offers a better understanding of the underlying risk and, therefore, aids in individual treatment decisions based on accurate risk assessment for the different patient groups," reports Principal Investigator Cihan Ay.

Within their review of the literature, the authors assessed a total of 5,951 studies published in the field of VTE in COVID-19. Of those, 86 studies were found eligible for inclusion and reported rates of thrombosis and pulmonary embolism in COVID-19 patients. After excluding additional studies due to underlying risk of bias in a structured assessment, 66 studies (28,173 patients) were found eligible to perform a meta-analysis to provide a robust estimate on risk of VTE in COVID-19.

The main findings are as follows: the overall VTE risk in hospitalized patients with COVID-19 is 14%, despite rigorous thromboprophylaxis regimens in most studies. Further, high heterogeneity in VTE rates was found between different patient subgroups. The rate was highest in patients admitted to intensive care units, with 23% of patients suffering VTE. Patients admitted to general wards suffered VTE in 8% of the cases. These findings underline the high risk of VTE in COVID-19 patients.

In addition, the authors specifically focused on estimating the risk of potentially life-threatening pulmonary embolism. The result: "This risk is considerably higher than in other comparable serious medical illnesses and ranges between 10 and 18% in COVID-19 patients requiring intensive care. Further, astonishingly, deep vein thrombosis was detected in almost half of the hospitalised COVID-19 patients who had been systematically screened for thrombosis using ultrasound." These findings underscore the strong impact of COVID-19 on the blood-clotting system. In addition, an exploratory analysis revealed that patients who developed deep vein thrombosis or pulmonary embolism during hospitalization had significantly higher D-dimer concentrations at admission, a laboratory parameter that indicates an activated coagulation system. This finding might be used to help develop personalized, risk-stratified thromboprophylaxis strategies in the future.

In summary, the authors provide a detailed evaluation of the risk of VTE based on the severity of the disease. Future studies need to determine whether elevated D-dimer at hospital admission justifies intensification of anticoagulant treatment in hospitalized patients with COVID-19.

###

SEE ORIGINAL STUDY




Filters close

Showing results

1120 of 4145
Released: 24-Nov-2020 4:35 PM EST
Cleveland Clinic Research Shows Bariatric Surgery May Reduce Severity of COVID-19 in Patients with Obesity
Cleveland Clinic

CLEVELAND: A Cleveland Clinic study shows that among patients who have obesity and who tested positive for COVID-19, a past history of bariatric surgery was significantly associated with a lower risk of hospital and intensive care unit admission. The results were published in the journal of Surgery for Obesity and Related Diseases.

Newswise: 249693_web.jpg
Released: 24-Nov-2020 3:40 PM EST
New therapy for flu may help in fight against COVID-19
Purdue University

A new therapy for influenza virus infections that may also prove effective against many other pathogenic virus infections, including HIV and COVID-19, has been developed by Purdue University scientists.

Released: 24-Nov-2020 3:30 PM EST
‘Crisis decision making at the speed of COVID-19’ – Bay Area public health officials share their experience with shelter-in-place order
Wolters Kluwer Health: Lippincott

In mid-March, public health officials across the San Francisco area issued the first U.S. regional shelter-in-place order in response to the emerging COVID-19 pandemic. A “field report” on the crisis decision-making approach followed in that effective early response is featured in a special COVID-19 supplement to the Journal of Public Health Management and Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Newswise: Research Helps Identify High-Risk Populations to aid
Health Officials Combating the Pandemic
Released: 24-Nov-2020 3:25 PM EST
Research Helps Identify High-Risk Populations to aid Health Officials Combating the Pandemic
UCLA Fielding School of Public Health

A team of UCLA Fielding School of Public Health researchers has developed a method to better guide public policy related to the control and prevention of COVID-19, based on identifying those most at risk in the pandemic

Released: 24-Nov-2020 3:15 PM EST
Workplace Expert: COVID-Safe Company Holiday Party Ideas and Why Celebrating is Significant
University of Maryland, Robert H. Smith School of Business

Maryland Smith workplace expert Vijaya Venkataramani says Zoom fatigue notwithstanding, a COVID-safe staff or company holiday celebration is ideal for leaders and managers to give thanks to team members for their resilience in 2020.

Newswise: Schooling Disrupted by the Pandemic in the United States Likely to Have Life-Long Impact, Study Says
Released: 24-Nov-2020 3:10 PM EST
Schooling Disrupted by the Pandemic in the United States Likely to Have Life-Long Impact, Study Says
UCLA Fielding School of Public Health

A team that includes UCLA Fielding School of Public Health researchers has found American children whose educations have been disrupted by the pandemic, even as little as 2-4 months, may face shortened life spans.

Newswise:Video Embedded hd-b-roll-of-cedars-sinai-vaccine-storage-freezers-now-available-for-download
VIDEO
Released: 24-Nov-2020 2:55 PM EST
HD B-roll of Cedars-Sinai Vaccine Storage Freezers Now Available for Download
Cedars-Sinai

B-roll available: Video shot today showing the freezers where Cedars-Sinai will store COVID-19 vaccines. Please note: There are NO vaccines in the video. The vaccines will not arrive until next month.

Released: 24-Nov-2020 2:35 PM EST
Three health care organizations call for centralized coordinated governmental action during ongoing COVID-19 pandemic
American College of Surgeons (ACS)

Centralized coordinated governmental action is critical during the resurgence of COVID-19, according to three national health care organizations.


Showing results

1120 of 4145

close
2.41423