How well does vaccination work in residents of long-term care homes

McMaster researchers aim to find out
18-Mar-2021 10:55 AM EDT, by McMaster University

Newswise — MONTREAL, MARCH 18, 2021 – Long-term care homes have been at the epicentre of the COVID-19 pandemic in Canada, with 70 percent of COVID-19 deaths having occurred in long-term care or nursing homes. 

The Government of Canada, through its COVID-19 Immunity Task Force (CITF), is supporting a study led by McMaster University researchers aimed at understanding how well vaccination works in residents of long-term care homes and which factors may be directly linked to outbreaks. Approximately $5 million is being provided for this study, one of the largest single studies focusing on long-term care homes in Canada. 

The study, which is in partnership with Schlegel Villages, St. Joseph’s Health System, and Health Sciences North Research Institute, will involve more than 2,000 residents, staff, and visitors of long-term care homes in Ontario over the course of a year. 

“We aim to determine how well vaccination works in residents of long-term care homes and discover whether a resident’s previous exposure to the virus or immune system response can protect them or make them vulnerable to further infection,” says Andrew Costa, PhD, co-principal investigator of the study, and Associate Professor of health research methods, evidence, and impact at McMaster. 

The team will also determine what factors within long-term care homes may be directly associated with outbreaks, and whether those homes with previous infections are likely to have future outbreaks. 

“We’ll be mapping this information with other available data to better understand the spread of the virus and immunity response across the province,” adds Dr. Costa. 

Co-principal investigator Dawn Bowdish, PhD, an immunologist and professor of medicine at McMaster, adds that outbreaks can still be expected, despite widespread vaccinations. 

“Although most residents are dangerously susceptible to COVID-19, some are resilient. Learning about how the immune system helps some residents teaches us how to make better vaccines and protect residents from future outbreaks,” she says. 

The research team is working with scientific partners at the Ontario Ministry of Health, Public Health Ontario, Schlegel-UW Research Institute for Aging (RIA), University of Toronto, the Health Sciences North Research Institute, St. Mary’s General Hospital and the University of Waterloo. PointClickCare Technologies and the Lung Health Foundation are supporting this research.

“Our research will influence health policy quickly because we are collaborating directly with provincial policymakers and COVID-19 decision-makers,” Dr. Bowdish explains. 

“Our team members and residents are proud to be part of this cutting edge and important study,” says James Schlegel, President and CEO of Schlegel Villages. “The results of this study will contribute greatly to a more robust understanding of COVID-19 in long-term care homes and will help us keep residents safe and healthy. We are honoured to work with the McMaster team and other partners to conduct this ground-breaking research.”

“This study presents an important opportunity for our member organizations to continue to learn more about COVID-19, its transmission in long-term care homes and what effect vaccination is having on virus transmission,” says David Wormald, President of St. Joseph's Health Centre Guelph and St. Joseph's Lifecare Centre Brantford, and Vice-President of elder care for St. Joseph's Health System. “We have come a long way in our understanding of COVID-19 in the last year and the continued learnings will help in our fight against COVID-19 at St. Joseph’s Health System and beyond.”

“COVID-19 has taken an enormous toll on the elderly and studies like this one are needed so we can better protect them going forward,” says Allison McGeer, MD, CITF Leadership Group member. “We encourage teams to work with those who can use the findings and implement them quickly, such as government, public health authorities, and key long-term care facility operators. This study is doing that.”

“Sadly, seniors have been disproportionately impacted by the COVID-19 pandemic,” says Dr. Theresa Tam, Canada’s Chief Public Health Officer. “This research collaboration will enhance our understanding of vaccine-induced immunity in seniors living in long-term care homes in order to better protect these residents in future”. 

The project is part of Canada’s Global Nexus for Pandemics and Biological Threats, an international network based at McMaster, with scientists, clinicians, engineers, social scientists and other experts working collaboratively to prevent future pandemics and mitigate global health threats.

 

About the COVID-19 Immunity Task Force In late April 2020, the Government of Canada established the COVID-19 Immunity Task Force with a two-year mandate. The Task Force is overseen by a Leadership Group of volunteers that includes leading Canadian scientists and experts from universities and healthcare homes across Canada who are focused on understanding the nature of immunity arising from the novel coronavirus that causes COVID-19. To that end, the CITF is supporting numerous studies to determine the extent of SARS-CoV-2 infection in Canada (in the general population as well as in specific communities and priority populations), understand the nature of immunity following infection, develop improved antibody testing methods, and help monitor the effectiveness and safety of vaccines as they are rolled out across Canada. The Task Force and its Secretariat accordingly work closely with a range of partners, including governments, public health agencies, institutions, health organizations, research teams, other task forces, and engages communities and stakeholders. Most recently, the Task Force has been asked to support vaccine surveillance, effectiveness and safety as part of its overall objective to generate data and ideas that inform interventions aimed at slowing—and ultimately stopping—the spread of SARS-CoV-2 in Canada. For more information visit: www.covid19immunitytaskforce.ca

 

 

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