Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults

Newswise — WHAT: A Phase 1 trial of an investigational mRNA vaccine to prevent SARS-CoV-2 infection has shown that the vaccine is well-tolerated and generates a strong immune response in older adults. A report published today in the New England Journal of Medicine describes the findings from the study, which was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. SARS-CoV-2 is the virus that causes COVID-19 disease.

The experimental vaccine, mRNA-1273, was co-developed by researchers at NIAID and Moderna, Inc. of Cambridge, Massachusetts. The Phase 1 trial began on March 16, 2020, and was expanded to enroll older adults about one month later. Older adults are more vulnerable to complications of COVID-19 and are an important population for vaccination. Understanding how the vaccine affects older adults is a critical part of measuring its safety and efficacy.

The trial was conducted at Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle, Emory University in Atlanta, and NIAID's Vaccine Research Center (VRC) clinic at the NIH Clinical Center in Bethesda, Maryland. Julie Ledgerwood, D.O., deputy director and chief medical officer at the VRC, oversaw the study at the NIH site. The Coalition for Epidemic Preparedness Innovations (CEPI) supported the manufacturing of the vaccine candidate for this trial. This trial is supported by the Infectious Diseases Clinical Research Consortium (IDCRC) through NIAID.

In its expansion to include older adults, the trial enrolled 40 healthy volunteers: 20 adults ages 56 to 70 years, and 20 adults ages 71 years and older. Ten volunteers in each age group received a lower dose of the vaccine (25 μg), and 10 volunteers in each age group received a higher dose (100 μg). After approximately one month, volunteers then received a second dose of the same vaccine at the same dosage. Throughout the study, volunteers attended clinic visits to track their responses to the vaccine and assess safety.

Overall, the researchers found that the investigational vaccine was well-tolerated in this older age group. Although some volunteers experienced some transient adverse effects, including fever and fatigue after vaccination, the researchers found that they also exhibited a good immune response to the vaccine: the blood of vaccinated volunteers contained robust binding and neutralizing antibodies against SARS-CoV-2. Importantly, the immune response to the vaccine seen in older volunteers was comparable to that seen in younger age groups.

The study will continue to follow the older volunteers for approximately a year after second vaccination to monitor the long-term effects of the vaccine. According to the researchers, these Phase 1 trial results further support testing of the investigational vaccine in older adults in an ongoing large Phase 3 trial.

###

 

NIAID conducts and supports research--at NIH, throughout the United States, and worldwide--to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health®

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 5402
Newswise: Palisades Medical Center COVID-19 Vaccine Efforts Support Community Health
Released: 14-Apr-2021 4:20 PM EDT
Palisades Medical Center COVID-19 Vaccine Efforts Support Community Health
Hackensack Meridian Health

Radames and Ana Arocho were all smiles when they arrived on the white school bus, and their enthusiasm was contagious.

Released: 14-Apr-2021 3:10 PM EDT
Most young people eager for COVID-19 vaccine, poll shows
Michigan Medicine - University of Michigan

As older teens and young adults become eligible for COVID-19 vaccination across the country, and younger teens await their turn, new survey data suggest a strong readiness that has grown since fall. But just as with older generations, a shrinking but still sizable minority of people age 14 to 24 say they’re not willing to get vaccinated, or that their decision will depend on safety.

Newswise: 261790_web.jpg
Released: 14-Apr-2021 12:10 PM EDT
A novel, quick, and easy system for genetic analysis of SARS-CoV-2
Osaka University

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic.

Newswise: COVID-19 Mortality Rates in Los Angeles County Higher in Communities with Poor Air Quality
Released: 14-Apr-2021 12:05 PM EDT
COVID-19 Mortality Rates in Los Angeles County Higher in Communities with Poor Air Quality
UCLA Fielding School of Public Health

A research project led by the UCLA Fielding School of Public Health has found that Los Angeles County neighborhoods with poor air quality had the highest death rates from the pandemic.

Released: 14-Apr-2021 10:05 AM EDT
Grant accelerates McMaster University, SQI Diagnostics effort to move infection testing innovation from lab to market
McMaster University

A new grant is helping McMaster University engineers and a Toronto precision-medicine diagnostics company to get infection-testing technology to market while generating opportunities for students.

Newswise: Suppression of COVID-19 Waves Reflects Time-Dependent Social Activity, Not Herd Immunity
Released: 14-Apr-2021 10:05 AM EDT
Suppression of COVID-19 Waves Reflects Time-Dependent Social Activity, Not Herd Immunity
Brookhaven National Laboratory

Scientists developed a new mathematical model for predicting how COVID-19 spreads, accounting for individuals’ varying biological susceptibility and levels of social activity, which naturally change over time.

14-Apr-2021 9:00 AM EDT
Lower COVID-19 rates seen in US states with higher adherence to mask wearing
PLOS

New evidence supports mask wearing in public as key to reducing spread of COVID-19

Newswise: So You Got Vaccinated Against COVID-19. Now What?
Released: 14-Apr-2021 8:05 AM EDT
So You Got Vaccinated Against COVID-19. Now What?
Michigan Medicine - University of Michigan

A slightly lighthearted guide to post-vaccination life, including how to help others who haven't gotten vaccinated yet.


Showing results

110 of 5402

close
2.1958