Los Alamos National Laboratory

Los Alamos study hopes to characterize and optimize ventilator treatment for Covid-19

Scientists and Engineers use computer modeling and experimental fluid mechanics to understand how tiny aerosol particles, when pulsed into the lung, may break up disease-related mucus and improve gas exchange

Newswise — LOS ALAMOS, N.M., December 21, 2020 — Cross-disciplinary scientists and engineers at Los Alamos National Laboratory are working to learn how Intrapulmonary Percussive Ventilation (IPV) helps clear mucus from blocking the airways of the human lung, a common reaction to the Covid-19 virus.  

Researchers, using some of the same modeling and experimental techniques from the Laboratory’s nuclear weapons mission, are working to discover the underlying science and engineering principles behind this process and have developed a preliminary machine learning algorithm that could someday assist pulmonary doctors in treating Covid-19 patients with IPV.

"People who have contracted the SARS-Cov2 virus may develop respiratory distress in which their lungs fill with mucus as a response to the viral infection.  As the lungs fill with mucus, the person may ultimately require mechanical ventilation," said John Bernardin, principal investigator for the project in the Laboratory's Mechanical and Thermal Engineering group. "This project is investigating how IPV pulsations of fine aerosols may help clear mucus from the patient's lungs, help them breathe while on a ventilator, and ultimately help them recover from the disease."

IPV is used alongside traditional ventilation to deliver rapid pulses of aerosol, depositing medication and potentially opening up clogged airway passages in the lung. Researchers are merging numerical and experimental approaches to develop a predictive model of lung behavior under these conditions.

The lung is a highly complex system, so the Laboratory is using acoustic measurements, computational fluid dynamics models, structural-fluid interaction models, and optical techniques to model the breathing process and observe aerosol flow and mucus breakup.  This is especially challenging because of the complex geometries in lung structure, multifaceted boundary conditions in the deep lung, and non-linear behavior of viscus fluids in the lung. The study requires analysis of how the lung responds to the kinetic energy of variable pressures, rotational flows, and sheer stresses on the lung walls.

To inform the mathematical models, the research team designed, built and tested several experimental devices, including a 3D printed "gas distribution manifold" that mimics the structures of the lung's trachea and bronchial branches.  They used sensors to measure pressure, velocity, temperature and humidity, along with a gas analyzer to measure pressure and volume, optical sensors to detect aerosol density and spectrometers to look at particle size distribution.  They also used lung tissue harvested from sheep carcasses and dyed aerosol to track the deposition of IPV aerosols during a ventilation-assisted process.

"We have learned that humidity has a strong effect on aerosol concentration," said Bernardin. "Dilution effects in the lung are less apparent with higher humidity, but more pronounced with increased volume flow rate, and aerosol penetration is much better during inhalation. We also discovered new mechanical dynamics and fluid mechanics (patent pending) that may further enhance the aerosol transport and mucus removal.”

The preliminary machine learning algorithm ties all the variables together, with the hope of eventually creating a rapid, patient-specific tool for estimating the proper ventilator and IPV settings for a particular patient before ventilation is begun, responding to and optimizing the treatment for each patient.

"The numerical modeling and experimentation tools required to study IPV are some of the same ones we use to design and test weapon systems, global security devices, and energy harvesting hardware," said Bernardin.  "Through the development of new tools to fight Covid-19, we demonstrate first hand how our national laboratory's people and equipment can quickly adapt and overcome to solve a complex problem that threatens our very way of life."

This project is a partnership with Idaho and Sandia National Laboratories, Presbyterian Health Services, Percussionaire (maker of IPV), and several other national experts in infectious disease sciences.  The project includes personnel from the Laboratory's Weapons Engineering, Biology, Theoretical, Weapons Modernization, Materials Physics and Applications, Computer, Computational and Statistical Sciences, and Physical Sciences organizations.

The project is funded by the U.S. Department of Energy - Office of Science through the CARES Act.

"The best part of this project was pulling together 20 people from all walks of life to respond to a challenging threat to the health and welfare of the world's population.  We are fighting back against Covid-19, trying to find a way to save human lives, including those of our colleagues, friends, family, and people we will never know, what can be more rewarding than that?" said Bernardin.

About Los Alamos National Laboratory (www.lanl.gov)

Los Alamos National Laboratory, a multidisciplinary research institution engaged in strategic science on behalf of national security, is managed by Triad, a public service oriented, national security science organization equally owned by its three founding members: Battelle Memorial Institute (Battelle), the Texas A&M University System (TAMUS), and the Regents of the University of California (UC) for the Department of Energy’s National Nuclear Security Administration. 

Los Alamos enhances national security by ensuring the safety and reliability of the U.S. nuclear stockpile, developing technologies to reduce threats from weapons of mass destruction, and solving problems related to energy, environment, infrastructure, health, and global security concerns.


Filters close

Showing results

110 of 4578
Newswise: UCLA Researcher’s Team Finds Common Blood Pressure Medications do not Increase COVID-19 Risk
Released: 18-Jan-2021 12:05 PM EST
UCLA Researcher’s Team Finds Common Blood Pressure Medications do not Increase COVID-19 Risk
UCLA Fielding School of Public Health

Dr. Marc Suchard, of the UCLA Fielding School of Public Health, co-led international research team looking at two widely used types of blood pressure drugs.

Newswise: UCLA Fielding School of Public Health Researchers Say Mask Mandates Could add $1 Trillion to the U.S. GDP
Released: 18-Jan-2021 12:05 PM EST
UCLA Fielding School of Public Health Researchers Say Mask Mandates Could add $1 Trillion to the U.S. GDP
UCLA Fielding School of Public Health

The team, including UCLA Fielding School of Public Health professors Anne Rimoin and Christina Ramirez, found that near-universal adoption of nonmedical masks in public, combined with complementary public health measures, could successfully eliminate spread of the infection. and add $1 Trillion to the U.S. GDP.

Released: 18-Jan-2021 10:45 AM EST
Mount Sinai Researchers Build Models Using Machine Learning Technique to Enhance Predictions of COVID-19 Outcomes
Mount Sinai Health System

Mount Sinai researchers have published one of the first studies using federated learning to examine electronic health records to better predict how COVID-19 patients will progress.

Newswise:Video Embedded pregnant-women-should-consider-taking-the-covid-19-vaccine
Released: 18-Jan-2021 7:50 AM EST
Pregnant women should consider taking the COVID-19 vaccine.
University of Washington School of Medicine

f pregnant individuals catch COVID they will generally get sicker than non-pregnant individuals. They also more commonly end up on ECMO [heart-lung support], in the ICU or on ventilators.

Newswise: Have allergies? Worried about COVID-19 vaccine? Don’t be.
Released: 18-Jan-2021 7:40 AM EST
Have allergies? Worried about COVID-19 vaccine? Don’t be.
UW Medicine

Even people who have experienced severe allergic reactions to food, latex, pets, pollen, or bee stings should get the coronavirus vaccine, UW Medicine allergy and infectious disease experts say.

Released: 15-Jan-2021 5:40 PM EST
Research Links Social Isolation to COVID-19 Protocol Resistance
Humboldt State University

As health officials continue to implore the public to wear masks and practice social distancing, recent research by Humboldt State University Psychology Professor Amber Gaffney provides key insights into connections between social isolation, conspiratorial thinking, and resistance to COVID-19 protocols.

Newswise: Rapid blood test identifies COVID-19 patients at high risk of severe disease
Released: 15-Jan-2021 5:35 PM EST
Rapid blood test identifies COVID-19 patients at high risk of severe disease
Washington University in St. Louis

Scientists at Washington University School of Medicine in St. Louis have shown that a relatively simple and rapid blood test can predict which patients with COVID-19 are at highest risk of severe complications or death. The blood test measures levels of mitochondrial DNA, which normally resides inside the energy factories of cells. Mitochondrial DNA spilling out of cells and into the bloodstream is a sign that a particular type of violent cell death is taking place in the body.

Released: 15-Jan-2021 2:55 PM EST
COVID-19 deaths really are different. But best practices for ICU care should still apply, studies suggest.
Michigan Medicine - University of Michigan

COVID-19 deaths are indeed different from other lung failure deaths, according to two recent studies, with 56% of COVID-19 patients dying primarily from the lung damage caused by the virus, compared with 22% of those whose lungs fail due to other causes. But, the researchers conclude, the kind of care needed to help sustain people through the worst cases of all forms of lung failure is highly similar, and just needs to be fine-tuned.

Released: 15-Jan-2021 2:50 PM EST
45% of adults over 65 lack online medical accounts that could help them sign up for COVID-19 vaccinations
Michigan Medicine - University of Michigan

As the vaccination of older adults against COVID-19 begins across the country, new poll data suggests that many of them don’t yet have access to the “patient portal” online systems that could make it much easier for them to schedule a vaccination appointment. In all, 45% of adults aged 65 to 80 had not set up an account with their health provider’s portal system.

Showing results

110 of 4578