Rush University Medical Center

Patients With COVID-19 May Have Higher Risk of Kidney Injury

Levels of protein called suPAR linked to acute kidney injury in patients studied

Newswise — Hospitalized patients with COVID-19 may face an increased risk for kidney injury, a dreaded complication for those suffering from infection with the novel 2019 coronavirus, an observational study led by University of Michigan researchers has found.

According to Jochen Reiser, MD, PhD, the Ralph C Brown MD professor and chairperson of Rush’s Department of Internal Medicine, patients with COVID-19 experience elevated levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.

“SuPAR is a circulating factor we’ve seen contribute to kidney injury in thousands of patients,” Reiser said. “RNA viruses such as HIV and SARS-CoV-2 (the virus that causes COVID-19) elicit a suPAR response of the innate immune system, leading to a rise in blood suPAR levels. If there is a hyperinflammatory suPAR response, kidney cells may be damaged.”

Reiser is an author of the multicenter study led by Salim Hayek MD, an assistant professor of cardiology at University of Michigan, “Soluble Urokinase Receptor in COVID-19 related Acute Kidney Injury.” Published online in the Journal of the American Society of Nephrology on Sept. 22, the study results show that more than a third patients with COVID-19 end up in need of dialysis and are also at much higher risk of death.

The research team tested suPAR levels of 352 study participants when they were admitted to the hospital for COVID-19 infection. A quarter of the participants developed acute kidney injury while hospitalized, and their median suPAR levels were more than 60% higher than those of the rest of the participants.

The risk of needing dialysis was increased 20-fold in patients with the highest suPAR levels. Overall, median suPAR levels for these study participants hospitalized with severe COVID-19 were almost three times higher than levels of healthy people.

“Certainly, a suPAR level at time of hospitalization of COVID-19 patients will provide an important risk stratification tool with respect to patient outcomes such as intubation or kidney failure,” Hayek said. “This will help hospitals by providing proper surveillance of patients at higher risk of a severe COVID-19 course.

“Now that we know the epidemiological link of suPAR to COVID-19-associated acute kidney injury (AKI), we must study if suPAR is a cause of COVID-19 associated AKI,” Reiser said. “In other words, can AKI in COVID-19 infected patients be prevented by keeping plasma suPAR levels low? This hypothesis is supported by the findings of the paper showing that COVID-19 infected study patients with a suPAR level below 4.6 ng/ml never needed dialysis. A newly developed and specific suPAR apheresis device is about to enter a clinical pilot trial where this scenario is tested.”




Filters close

Showing results

110 of 3765
Released: 23-Oct-2020 4:55 PM EDT
Woman recovering from COVID-19 shares experience as monoclonal antibody clinical trial participant
University of Texas Health Science Center at Houston

When Christina Loville tested positive for the coronavirus, she was terrified. She decided to channel her fear into researching COVID-19 treatments, where she discovered a local clinical trial led by experts at The University of Texas Health Science Center at Houston (UTHealth).

Released: 23-Oct-2020 4:30 PM EDT
"Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29, 3PM EDT
Newswise

"Third spike" in COVID-19 cases, plus the vaccine trials: Live Expert Panel for October 29, 3PM EDT

Released: 23-Oct-2020 1:50 PM EDT
Are we really “rounding the corner" when it comes the coronavirus pandemic?
Newswise

“We’re rounding the turn,” Trump said during the debate. This implies a meaningful improvement. We rate this claim as false. On that very same day the U.S. recorded 77,000 new cases, according to NBC News. This tops the previous high that had been set in July. We may be learning to "live with it," as Trump mentioned, but this is not an improvement.

Newswise: 246719_web.jpg
Released: 23-Oct-2020 12:50 PM EDT
NRL researchers evaluate ultraviolet sources, combat COVID-19
United States Naval Research Laboratory

U.S. Naval Research Laboratory researchers evaluated commercial ultraviolet (UV) sources for viral disinfection to combat COVID-19 on land and at sea, and established a dedicated UV characterization lab in five days to ensure safe introduction and effective operation of UV sources across the Fleet.

Released: 23-Oct-2020 12:05 PM EDT
COVID-19 anxiety linked to body image issues
Anglia Ruskin University

A new study has found that anxiety and stress directly linked to COVID-19 could be causing a number of body image issues amongst women and men.

Newswise: 246747_web.jpg
Released: 23-Oct-2020 11:45 AM EDT
Eliminating COVID-19: What the world can learn from NZ and Taiwan
University of Otago

Both Taiwan and New Zealand have successfully eliminated COVID-19 with world-leading pandemic responses. By taking a particularly proactive approach, Taiwan's response was probably the most effective and least disruptive of any country's, researchers say.

Released: 23-Oct-2020 11:00 AM EDT
Healthcare's earthquake: Lessons from COVID-19
Beth Israel Deaconess Medical Center

The COVID-19 pandemic has fundamentally disrupted U.S. healthcare organizations.

Released: 23-Oct-2020 10:50 AM EDT
COVID-19 lockdown reduced mental health, sleep, exercise
Pennington Biomedical Research Center

A first-of-its-kind global survey shows the initial phase of the COVID-19 lockdown dramatically altered our personal habits, largely for the worse.

Released: 23-Oct-2020 10:45 AM EDT
New Data on Increasing Cloth Mask Effectiveness
Society for Risk Analysis (SRA)

A new study published in Risk Analysis, “Reinventing cloth masks in the face of pandemics,” by Stephen Salter, P.Eng., describes how Effective Fiber Mask Programs (EFMPs) can help communities find a balance between the economy and curbing community spread.


Showing results

110 of 3765

close
0.80781