• Patients with kidney failure who are undergoing dialysis—whether at dialysis clinics or at home—face a higher risk of developing COVID-19 and a higher risk of dying from the disease. 

Newswise — Washington, DC (June 9, 2021) — Individuals with kidney failure who receive dialysis treatments in clinics (called in-center dialysis) are especially vulnerable to COVID-19, with death rates reported at over 20% in recent studies; however, there has been a dearth of information specific to patients who undergo dialysis sessions at home. A new study appearing in an upcoming issue of JASN indicates that these patients are similarly vulnerable to becoming infected with the virus that causes COVID-19, and from dying from the disease.

For the study, a team led by Caroline M. Hsu, MD and Eduardo Lacson Jr, MD, MPH (Tufts Medical Center and Dialysis Clinic, Inc.) examined information on all patients who received home dialysis through Dialysis Clinic, Inc. (a national not-for-profit dialysis provider serving approximately 2,000 home dialysis patients) from February 22, 2020 to December 31, 2020. The information was compared with data pertaining to patients who receive in-center dialysis.

The researchers found that 4.5% of home dialysis patients had COVID-19 between February and September, with Black race, Hispanic ethnicity, and long-term care facility residence being significant risk factors. From October to December, 6.4% of home dialysis patients had COVID-19.

“Early in the pandemic, patients receiving in-center dialysis treatments had higher rates of COVID-19 compared with those receiving home dialysis treatments; however, with increasing community spread of COVID-19, including into rural areas, more home dialysis patients became infected and infection rates increased,” said Dr. Lacson. “In contrast, infection rates of COVID-19 among in-center patients declined slightly over time, which we believe reflected both greater testing capacity nationwide, and the implementation of rigorous infection control practices in healthcare settings, including nursing homes.”

The researchers noted that patients undergoing dialysis, regardless of the site of dialysis treatment, exhibited higher rates of COVID-19 compared with the general population. “More importantly, their mortality rate of about 13%, while lower than it was earlier in the pandemic, remains devastatingly elevated,” said Dr. Hsu. “We therefore strongly urge all dialysis patients to be vaccinated and continue to practice social distancing, mask wearing, and other public health precautions.”

Study co-authors include Daniel E. Weiner, MD MS, Gideon Aweh, MS, Page Salenger, MD, and Douglas S. Johnson, MD, JD.

Disclosures:  Mr. Aweh, Dr. Salenger, Dr. Johnson, and Dr. Lacson Jr are all employees of Dialysis Clinic, Inc. (DCI), where Dr. Johnson is Vice Chair of the Board. Dr. Weiner receives salary support to his institution from DCI. Dr. Hsu receives support from NIDDK T32DK007777. Dr. Hsu’s funder had no role in study design, data collection, reporting, or the decision to submit for publication.

The article, titled “COVID-19 in Home Dialysis Patients: Epidemiology and Outcomes as Compared to In-Center Dialysis Patients,” will appear online at http://jasn.asnjournals.org/ on June 9, 2021, doi: 10.1681/ASN.2020111653.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has more than 21,000 members representing 131 countries. For more information, visit www.asn-online.org.


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Journal Link: JASN