To Better Understand COVID-19, Researchers Review Aging, Immune Response to Viral Infections

Michigan Medicine - University of Michigan

Newswise — Information about the new COVID-19 infection is constantly evolving based on what clinicians see firsthand. One constant, so far, is that the older population tends to fare worse than younger folks with this disease.

A team led by Daniel Goldstein, M.D., already studies aging and the influenza viral infection, and took this spring away from their lab to figure out if any of their other research, and other research they regularly read, could be helpful in the fight against COVID-19.

“Influenza is of course a different pathogen, but it may give some catalyst for research with the current SARS-CoV2 infection,” says Goldstein, of the Michigan Medicine Frankel Cardiovascular Center. Goldstein, with Judy Chen, a doctoral student, and William Kelley, a postdoctoral research fellow, published a new review in the Journal of Immunology.

“We believe some of the phenomena that we’re seeing with the current pandemic are similar to what we’ve seen in our research with aging,” Goldstein says. “There seems to be a higher mortality because of dysregulated inflammation more than impaired viral control.”

Additionally, increasing activation of neutrophils is reported in the current COVID-19 pandemic, which the authors have reported in their flu models. And how aging affects the immune system prior to infection is the same, and also potentially applicable in understanding the population afflicted by COVID-19, the authors say.

“However, there are certainly some unique things about this virus we’re still learning,” Goldstein says.

SEE ORIGINAL STUDY




Filters close

Showing results

110 of 3462
Newswise: 244463_web.jpg
Released: 30-Sep-2020 3:45 PM EDT
Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults
NIH, National Institute of Allergy and Infectious Diseases (NIAID)

A Phase 1 trial of an investigational mRNA vaccine to prevent SARS-CoV-2 infection has shown that the vaccine is well-tolerated and generates a strong immune response in older adults.

Newswise: Tufts University to lead $100M program to reduce risk of zoonotic viral spillover, spread
Released: 30-Sep-2020 2:10 PM EDT
Tufts University to lead $100M program to reduce risk of zoonotic viral spillover, spread
Tufts University

Tufts University will lead a $100 million, five-year program to understand and address threats posed by zoonotic viral diseases that can “spill over” from animals to humans, such as SARS-CoV-2, in an effort to reduce risk of infection, amplification, and spread, USAID announced today.

Newswise: Guiding Communities Through Alerts and Warnings for COVID-19, Other Emergencies
Released: 30-Sep-2020 1:55 PM EDT
Guiding Communities Through Alerts and Warnings for COVID-19, Other Emergencies
Homeland Security's Science And Technology Directorate

DHS S&T has been working with the FEMA IPAWS office and state and local response teams since early 2009 to develop effective alerts, warnings, and notifications programs, as well as identifying gaps in existing IPAWS alerting messaging.

Newswise:Video Embedded uw-researchers-driving-around-seattle-to-track-covid-19-response-over-time
VIDEO
Released: 30-Sep-2020 1:55 PM EDT
UW researchers driving around Seattle to track COVID-19 response over time
University of Washington

University of Washington researchers developed a project that scans the streets every few weeks to document how Seattle has reacted to the pandemic and what recovery looks like.

Newswise: 244496_web.jpg
Released: 30-Sep-2020 1:50 PM EDT
The ancient Neanderthal hand in severe COVID-19
Okinawa Institute of Science and Technology Graduate University - OIST

Since first appearing in late 2019, the novel virus, SARS-CoV-2, has had a range of impacts on those it infects.

access_time Embargo lifts in 2 days
Embargo will expire: 2-Oct-2020 12:15 AM EDT Released to reporters: 30-Sep-2020 1:50 PM EDT

A reporter's PressPass is required to access this story until the embargo expires on 2-Oct-2020 12:15 AM EDT The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Released: 30-Sep-2020 12:55 PM EDT
Study supports airborne spread of COVID-19 indoors
JAMA - Journal of the American Medical Association

New research from the University of Georgia supports growing evidence for airborne transmission of COVID-19 in enclosed spaces.

access_time Embargo lifts in 2 days
Embargo will expire: 2-Oct-2020 11:00 AM EDT Released to reporters: 30-Sep-2020 12:30 PM EDT

A reporter's PressPass is required to access this story until the embargo expires on 2-Oct-2020 11:00 AM EDT The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.


Showing results

110 of 3462

close
0.96689