University of Illinois Chicago

‘Wonder material’ can be used to detect COVID-19 quickly, accurately

Researchers show a graphene-based sensor can detect SARS-CoV-2
16-Jun-2021 11:55 AM EDT, by University of Illinois Chicago

Newswise — Researchers at the University of Illinois Chicago have successfully used graphene — one of the strongest, thinnest known materials — to detect the SARS-CoV-2 virus in laboratory experiments. The researchers say the discovery could be a breakthrough in coronavirus detection, with potential applications in the fight against COVID-19 and its variants.

In experiments, researchers combined sheets of graphene, which are more than 1,000 times thinner than a postage stamp, with an antibody designed to target the infamous spike protein on the coronavirus. They then measured the atomic-level vibrations of these graphene sheets when exposed to COVID-positive and COVID-negative samples in artificial saliva. These sheets were also tested in the presence of other coronaviruses, like Middle East respiratory syndrome, or MERS-CoV.

The UIC researchers found that the vibrations of the antibody-coupled graphene sheet changed when treated with a COVID-positive sample, but not when treated with a COVID-negative sample or with other coronaviruses. Vibrational changes, measured with a device called a Raman spectrometer, were evident in under five minutes.

Their findings are published in the journal ACS Nano.

“We have been developing graphene sensors for many years. In the past, we have built detectors for cancer cells and ALS. It is hard to imagine a more pressing application than to help stem the spread of the current pandemic,” said Vikas Berry, professor and head of chemical engineering at the UIC College of Engineering and senior author of the paper. “There is a clear need in society for better ways to quickly and accurately detect COVID and its variants, and this research has the potential to make a real difference. The modified sensor is highly sensitive and selective for COVID, and it is fast and inexpensive.”

“This project has been an amazingly novel response to the need and demand for detection of viruses, quickly and accurately,” said study co-author Garrett Lindemann, a researcher with Carbon Advanced Materials and Products, or CAMP. “The development of this technology as a clinical testing device has many advantages over the currently deployed and used tests.”

Berry says that graphene — which has been called a “wonder material” — has unique properties that make it highly versatile, making this type of sensor possible.

Graphene is a single-atom-thick material made up of carbon. Carbon atoms are bound by chemical bonds whose elasticity and movement can produce resonant vibrations, also known as phonons, which can be very accurately measured. When a molecule like a SARS-CoV-2 molecule interacts with graphene, it changes these resonant vibrations in a very specific and quantifiable way.

“Graphene is just one atom thick, so a molecule on its surface is relatively enormous and can produce a specific change in its electronic energy,” Berry said. “In this experiment, we modified graphene with an antibody and, in essence, calibrated it to react only with the SARS-CoV-2 spike protein. Using this method, graphene could similarly be used to detect COVID-19 variants.”

The researchers say the potential applications for a graphene atomic-level sensor — from detecting COVID to ALS to cancer — continue to expand.

A provisional patent has been submitted based on this work.

Additional co-authors of the paper include Ngoc Hoang Lan Nguyen and Sungjoon Kim of UIC. The work has been funded by Ramaco Carbon and their affiliate CAMP, and partly by the Office of Naval Research.

SEE ORIGINAL STUDY



Filters close

Showing results

110 of 6084
Newswise: Public
Released: 28-Jul-2021 2:45 PM EDT
Highly Potent, Stable Nanobodies Stop SARS-CoV-2
Max Planck Society (Max-Planck-Gesellschaft)

Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.

Newswise: Public
Released: 28-Jul-2021 2:20 PM EDT
Psychological Consequences of COVID-19 in Health Care
University of Bonn

Physicians, nursing staff, medical technical assistants, and pastoral workers in hospitals: they have all been placed under severe strain by the Covid-19 pandemic.

Newswise: Public
Released: 28-Jul-2021 2:10 PM EDT
Why Lockdown in Africa Does Not Work as a First COVID-19 Pandemic Response
University of Johannesburg

In an African pandemic it is more productive to consider lockdowns, after using other non-medical measures first, Especially in countries with high levels of poverty and corruption, says Prof Nicholas Ngepah, a Professor of Economics at the University of Johannesburg in South Africa.

Newswise:Video Embedded how-to-talk-with-people-who-are-not-vaccinated-against-covid-19
VIDEO
Released: 28-Jul-2021 1:40 PM EDT
How to Talk With People Who Are Not Vaccinated Against COVID-19
Cedars-Sinai

Even though she has asthma, putting her at higher risk for severe complications from COVID-19, Angela Reeves-Flores, 33, waited until a week ago to get vaccinated.

Newswise: Indian Women’s Nutrition Suffered During COVID-19 Lockdown
Released: 28-Jul-2021 12:50 PM EDT
Indian Women’s Nutrition Suffered During COVID-19 Lockdown
Cornell University

A new study from Cornell University finds the nationwide lockdown India imposed last year in response to COVID-19 caused disruptions that negatively impacted women’s nutrition.

Released: 28-Jul-2021 12:00 PM EDT
MD Anderson Research Highlights for July 28, 2021
University of Texas M. D. Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a newly discovered protein that controls B cell survival, understanding epigenetic changes in malignant peripheral nerve sheath tumors (MPNSTs) and melanoma, identifying a protein that protect genome stability, developing novel cell therapies for COVID-19, a new option for treating neuropathic pain, exosome delivery of CRISPR/Cas9 to pancreatic cancer, discovering how cancer cells tolerate aneuploidy and the role of health disparities in long-term survival of adolescent and young adult patients with Hodgkin lymphoma.

Released: 28-Jul-2021 11:30 AM EDT
Study Reveals Characteristics of SARS-CoV-2 Spike Protein
University of Kentucky

A new University of Kentucky College of Medicine study published in the Journal of Biological Chemistry provides foundational information about SARS-CoV-2’s spike protein.

access_time Embargo lifts in 2 days
Embargo will expire: 4-Aug-2021 9:00 AM EDT Released to reporters: 28-Jul-2021 11:15 AM EDT

A reporter's PressPass is required to access this story until the embargo expires on 4-Aug-2021 9:00 AM EDT The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Newswise: UIC Awarded $6 Million to Develop Potential COVID-19 Treatment
Released: 28-Jul-2021 10:15 AM EDT
UIC Awarded $6 Million to Develop Potential COVID-19 Treatment
University of Illinois Chicago

Researchers at the University of Illinois Chicago are developing a potential treatment for COVID-19, thanks to a $6 million technology and therapeutic development award from the U.S. Department of Defense supporting pre-clinical animal studies.

Newswise: Don’t Let the Raging Virus Put Life in Jeopardy. Chula Recommends How to Build an Immunity for Your Heart Against Stress and Depression
Released: 28-Jul-2021 8:55 AM EDT
Don’t Let the Raging Virus Put Life in Jeopardy. Chula Recommends How to Build an Immunity for Your Heart Against Stress and Depression
Chulalongkorn University

Cumulative stress, denial, and chronic depression are the byproducts of the COVID-19 pandemic. The Center for Psychological Wellness, Chulalongkorn University recommends ways to cope by harnessing positive energy from our heart.


Showing results

110 of 6084

close
3.76603