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    • 2016-02-29 17:05:15
    • Article ID: 648951

    PPPL Inventors Win Award for Device That Creates Medical Isotope Vital for Diagnosing Diseases

    • Credit: Photo by Elle Starkman/PPPL Office of Communications

      Charles Gentile, right, and co-inventor George Ascione, show off their award at the 11th Annual Innovation Forum at the Andlinger Center for Energy and the Environment on Feb. 24.

    • Credit: Photo by Elle Starkman/PPPL Office of Communications

      Charles Gentile presents to judges seated in the front row at the Innovation Forum.

    • Credit: Photo by Elle Starkman/PPPL Office of Communications

      The winners of Innovation Forum awards from left to right: Jake Herb, Jen-Tang Lu, Gentile, and Gilad Arwatz.

    Charles Gentile, an engineer at the U.S. Department of Energy's Princeton Plasma Physics Laboratory, and fellow inventors George Ascione and Adam Cohen won third prize at Princeton University Keller Center’s 11th Annual Innovation Forum on Feb. 24 for their invention of an on-demand method to create a badly needed isotope used routinely in medical imaging for diagnosis.

    The invention could help solve a worldwide shortage of a radioactive element that is crucial in medical scanning devices used to diagnose diseases such as heart disease and breast cancer. And it does so without the use of uranium. The refrigerator-sized device can produce Technetium-99m (Tc-99m), the substance used in most medical diagnostic procedures, in a hospital or doctor’s office. This could make the substance more available to third-world countries, Gentile said. And unlike the production of Tc-99m in nuclear reactors, there is no danger of nuclear proliferation associated with the device because it does not use uranium.

    The award gives Gentile, the head of the Tritium Systems Group at PPPL, and Ascione, the head of the Health Physics Division, $5,000 to develop their invention. The third inventor was Cohen, the Deputy Undersecretary for Science and Energy at the U.S. Department of Energy, who formerly was deputy director for operations at PPPL when he worked on the technology.

    “I’m really happy,” Gentile said after receiving the award. “They know we’re onto something and we’re going to have a positive impact.”

    Recently awarded a patent

    Ascione said he and Gentile are looking forward to receiving a patent. The inventors recently learned through Princeton’s Office of Technology Licensing that the device has been received a patent and expect the patent to issue any day. “It’s a great thing,” Ascione added. “This is really a payoff for all the hard work we put in.”

    Princeton University’s Keller Center, which hosted the event along with the Office of Technology Licensing, invited Gentile and six other inventors to present their inventions at The Innovation Forum, held at Princeton’s Andlinger Center for Energy and the Environment’s Maeder Hall, before a panel of judges made up of entrepreneurs and venture capitalists. The judges decided this year to award not one but two third-place prizes along with the first and second-place prizes. “The judges really fell in love with many of the inventions,” said Cornelia Huellstrunk, the executive director of the Keller Center.

    Jen-Tang Lu, a Princeton University Ph.D. candidate in electrical engineering, won first place for his invention to enhance ultrasound imaging. Jake Herb, a chemistry Ph.D. candidate, won second place for his method of producing low-cost green electrolytes for magnesium-ion batteries. The other third place prize winner was Gilad Arwatz, a postdoctoral researcher in mechanical and aerospace engineering, for a nano-wire that provides a faster, cheaper and more compact device to measure temperature, velocity and humidity.

    Gentile said his invention would help fill a need for Tc-99m, which is used in two-thirds of medical diagnostic procedures around the world and is part of a multi-billion dollar radioisotope industry. There is currently a worldwide shortage of the material due to nuclear reactors being shut down. A facility in Chalk River, Ontario, Canada, which is one of the main producers of the substance, is slated to shut down this year, Gentile said.

    Doctors inject Tc-99 m to diagnose conditions ranging from brain tumors to heart disease. The isotope emits gamma rays that scanning devices can easily trace. Since the substance has a half-life of six hours, the radiation exposure to patients is kept to a minimum. But the half-life also makes it difficult to ship to third-world countries that are more than six hours away from the reactors that produce the substance. Gentile said he hopes that hospitals and medical centers in these areas would be able to use the device to produce Tc-99m themselves. Gentile told the judges that he could produce a prototype of the refrigerator-sized device within a year. “We would like to get this material to many places where people now can’t access it,” he said.

    Laurie Bagley, head of Technology Transfer at PPPL, said she was happy to see the invention recognized. “The technology is potentially life changing for those who would now have access to this medical isotope,” she said.

    PPPL, on Princeton University's Forrestal Campus in Plainsboro, N.J., is devoted to creating new knowledge about the physics of plasmas — ultra-hot, charged gases — and to developing practical solutions for the creation of fusion energy. Results of PPPL research have ranged from a portable nuclear materials detector for anti-terrorist use to universally employed computer codes for analyzing and predicting the outcome of fusion experiments. The Laboratory is managed by the University for the U.S. Department of Energy’s Office of Science, which is the largest single supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.

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    Story Tips: Pandemic impact, root studies, neutrons confirm, lab on a crystal and modeling fusion

    ORNL Story Tips: Pandemic impact, root studies, neutrons confirm, lab on a crystal and modeling fusion


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    Natalie Roe Named Berkeley Lab's Associate Director for Physical Sciences

    Natalie Roe Named Berkeley Lab's Associate Director for Physical Sciences

    Natalie Roe, who joined Lawrence Berkeley National Laboratory (Berkeley Lab) as a postdoctoral fellow in 1989 and has served as Physics Division director since 2012, has been named the Lab's Associate Laboratory Director (ALD) for the Physical Sciences Area. Her appointment was approved by the University of California. The announcement follows an international search.

    Brookhaven Lab Partners in New $40 M Research Center to Convert Sunlight to Liquid Fuels

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    UPTON, NY--The U.S. Department of Energy (DOE) has announced $40M in funding over five years for a new research center aimed at developing hybrid photoelectrodes for converting sunlight into liquid fuels. Chemists from DOE's Brookhaven National Laboratory will be key partners in this effort, dubbed the Center for Hybrid Approaches in Solar Energy to Liquid Fuels (CHASE), which will be led by the University of North Carolina at Chapel Hill (UNC) and includes additional collaborators at Emory University, North Carolina State University, the University of Pennsylvania, and Yale.

    Fermilab scientist Laura Fields receives $2.5 million DOE award to study beams of shape-shifting ghost particles

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    Summer Sundays Go Virtual

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    Geothermal Brines Could Propel California's Green Economy

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    Deep beneath the surface of the Salton Sea, a shallow lake in California's Imperial County, sits an immense reserve of critical metals that, if unlocked, could power the state's green economy for years to come. These naturally occurring metals are dissolved in geothermal brine, a byproduct of geothermal energy production. Now the race is on to develop technology to efficiently extract one of the most valuable metals from the brine produced by the geothermal plants near the Salton Sea: lithium.

    Magnum Venus Products licenses ORNL co-developed additive manufacturing technologies

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    Berkeley Lab Part of Multi-Institutional Team Awarded $60M for Solar Fuels Research

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    Will Fox wins 2020 John Dawson Award for producing new insights into astrophysical shockwaves

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    Jefferson Lab ES&H Deputy Director Receives Health Physics Society Honor

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    Robert Ainsworth awarded $2.5 million to improve particle beams for high-intensity experiments

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    Harvesting Energy from Light using Bio-inspired Artificial Cells

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    Excavating Quantum Information Buried in Noise

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    How Electrons Move in a Catastrophe

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    Lanthanum strontium manganite (LSMO) is a widely applicable material, from magnetic tunnel junctions to solid oxide fuel cells. However, when it gets thin, its behavior changes for the worse. The reason why was not known. Now, using two theoretical methods, a team determined what happens.

    When Ions and Molecules Cluster

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    How an ion behaves when isolated within an analytical instrument can differ from how it behaves in the environment. Now, Xue-Bin Wang at Pacific Northwest National Laboratory devised a way to bring ions and molecules together in clusters to better discover their properties and predict their behavior.

    Tune in to Tetrahedral Superstructures

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    Shape affects how the particles fit together and, in turn, the resulting material. For the first time, a team observed the self-assembly of nanoparticles with tetrahedral shapes.

    Tracing Interstellar Dust Back to the Solar System's Formation

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    Investigating Materials that Can Go the Distance in Fusion Reactors

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    Future fusion reactors will require materials that can withstand extreme operating conditions, including being bombarded by high-energy neutrons at high temperatures. Scientists recently irradiated titanium diboride (TiB2) in the High Flux Isotope Reactor (HFIR) to better understand the effects of fusion neutrons on performance.

    Better 3-D Imaging of Tumors in the Breast with Less Radiation

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    In breast cancer screening, an imaging technique based on nuclear medicine is currently being used as a successful secondary screening tool alongside mammography to improve the accuracy of the diagnosis. Now, a team is hoping to improve this imaging technique.

    Microbes are Metabolic Specialists

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    Scientists can use genetic information to measure if microbes in the environment can perform specific ecological roles. Researchers recently analyzed the genomes of over 6,000 microbial species.


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