DOE News
    Doe Science news source
    The DOE Science News Source is a Newswise initiative to promote research news from the Office of Science of the DOE to the public and news media.
    • 2017-09-20 14:05:30
    • Article ID: 681502

    Titan Helps Researchers Suck Mystery Out of Cell’s ‘Vacuum Cleaners’

    UIUC simulation aids understanding of multidrug resistance in cancer cells

    • Credit: University of Illinois at Urbana-Champaign

      An image depicting P-glycoproteins’s transition from its inward-facing state to its outward-facing state. For the first time, UIUC researchers successfully captured the protein’s outward-facing dynamics.

    In the fight against cancer, cancer cells often find ways to fight back. One means is by stocking the cell membrane with proteins that pump foreign substances—including anticancer drugs—out of the cell. This trait can result in multidrug resistance that undermines the effectiveness of cancer treatment.

    To combat this defense mechanism, scientists are turning to supercomputers and molecular dynamics to better understand the function of a membrane transport protein called P-glycoprotein, or Pgp. In healthy cells, Pgp acts as the cell’s vacuum cleaner, removing unwanted or toxic substances. But to treat cancer, doctors sometimes need to temporarily pull the plug on these molecular pumps. The task requires developing targeted drugs based on a thorough understanding of Pgp’s makeup and mechanics.

    Recently, a team led by computational biophysicist Emad Tajkhorshid from the University of Illinois at Urbana-Champaign (UIUC) uncovered new details about Pgp that could help the drug discovery community. Using the Cray XK7 Titan supercomputer, a 27-petaflop system housed at the Oak Ridge Leadership Computing Facility(OLCF), a US Department of Energy (DOE) Office of Science User Facility at DOE’s Oak Ridge National Laboratory, the team produced the first experimentally verified all-atom look at a mammalian Pgp in its outward-facing state (open to the outside of the cell) within a biological membrane. The simulation work also produced clues related to the structural integrity of the protein. The team’s results were published in Nature in March 2017.

    “There are many challenges to imaging and simulating a transporter like Pgp, but by using a unique method that combines experimental data with molecular dynamics and computing, our team was able to discover new information about this key cellular component,” said Sundarapandian Thangapandian, a team member and postdoctoral researcher at UIUC. “These findings could aid in drug discovery, where researchers are looking for better Pgp inhibitors, drugs that block transporter function and make it easier for anticancer drugs to do their job.”

    Probing the pump

    Like any good vacuum cleaner, Pgp isn’t picky about the substances it attracts and expels from the cell. The list includes a large number of drug molecules with hydrophobic (water-repelling) and hydrophilic (water-attracting) groups in their chemical structure. In addition to cancer drugs, the list includes cardiovascular drugs, antibiotics, and steroid hormones.

    Wedged within the cell’s lipid membrane, the transporter’s broad selectivity is a product of its design. Pgp consists of two complementary subunits, with each subunit containing a transmembrane domain and a nucleotide-binding domain. When a foreign molecule, or substrate, binds to Pgp’s transmembrane domain, a series of conformational changes is triggered. These changes allow adenosine triphosphate (ATP), the universal energy currency of the cell, to attach to Pgp’s nucleotide-binding domains and power the transmembrane domains’ inversion. The action, analogous to a complex gate swinging open, causes the protein to release the substrate out of the cell and Pgp to return to its closed-gate, unbound configuration.

    To gain a more comprehensive picture of this process, Tajkhorshid’s team relied on detailed molecular measurements captured via a spectroscopy method called double electron–electron resonance by a Vanderbilt University team led by Hassane Mchaourab, a professor of molecular physiology and biophysics. These experiments provided precise information that allowed the team to construct its model based on data from a mammalian Pgp both in its inward-facing state (open to the inside of the cell) and in its outward-facing state.

    “Because of the protein’s high degree of dynamics, no one had ever been able to experimentally provide atomic-level structural details on the outward-facing state of the protein,” Thangapandian said.

    With the newly minted model, Tajkhorshid’s team, in effect, possessed a lock in need of a key. That key came in the form of the OLCF’s Titan, to which the team gained access through a 100-million core-hour allocation awarded through DOE’s INCITE (Innovative and Novel Computational Impact on Theory and Experiment) program.

    Using the molecular dynamics code NAMD, the UIUC team explored Pgp’s mechanics by dividing the protein into five distinct simulation sets. Run on Titan, the setup allowed the team to scrutinize Pgp’s components in isolation before bringing them all together. Thangapandian, who managed the simulations, compiled 300 nanoseconds of simulation time for each subunit—aggregating 1.5 microseconds of the Pgp model in total.

    Aiding drug discovery

    The substantial sum of simulation data unlocked a trove of new insights, including the ATP-powered mechanism Pgp uses to alter substrate access from inside the cell to outside the cell. This so-called alternating access mechanism consists of a “two-stroke” sequence that closes and opens the protein. “This means one ATP is needed to close the inner side of the protein, and a second is needed to open the outer side,” Thangapandian said.

    In the midst of this energy transfer, the team documented 60 interactions involving different atoms. The new mechanics play an important role in bringing together Pgp’s nucleotide-binding domains into a single chemical structure, a process known as dimerization.

    Additionally, the team discovered factors that contribute to Pgp’s structural stability in its outward-facing state. The findings include a “salt bridge”—an ionic coupling between positively and negatively charged amino acids—and interactions between the protein and adjoining lipids in the cell membrane that contribute to the protein’s structural integrity.

    With Pgp’s two end states now well characterized, Tajkhorshid’s team is shifting its attention to the action in between, work that could lend additional insights to biologists and medicinal chemists. Capturing this level of detail requires additional computational sampling of the process, a goal that is now being pursued on the Blue Waters supercomputer at the National Center for Supercomputing Applications located at UIUC.

    “We want to give researchers focused on Pgp a set of stable intermediate states to target as well,” Thangapandian said. “That would really improve the effectiveness of the drug discovery process.”

    Related publication: Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A. Koteiche, Robert K. Nakamoto, Emad Tajkhorshid, and Hassane S. Mchaourab, “Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein.” Nature 543, no. 7647 (2017): 738–741. doi:10.1038/nature21414.

    This research was funded by the National Institutes of Health. UT-Battelle manages ORNL for the DOE Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, please visit http://science.energy.gov.

    X
    X
    X
    • Filters

    • × Clear Filters
    For Better Predictions, Researchers Evaluate Tropical Cyclone Simulation in the Energy Exascale Earth System Model

    For Better Predictions, Researchers Evaluate Tropical Cyclone Simulation in the Energy Exascale Earth System Model

    Infrastructure planning requires accurately predicting how tropical cyclones respond to environmental changes. To make those predictions, researchers use Earth system models. In this research, scientists analyzed tropical cyclones simulated by the Department of Energy's Energy Exascale Earth System Model (E3SM). They found that high resolution is critical to simulating tropical cyclones and their interactions with the ocean.

    Experts' Predictions for Future Wind Energy Costs Drop Significantly

    Experts' Predictions for Future Wind Energy Costs Drop Significantly

    Technology and commercial advancements are expected to continue to drive down the cost of wind energy, according to a survey led by Berkeley Lab of the world's foremost wind power experts. Experts anticipate cost reductions of 17%-35% by 2035 and 37%-49% by 2050, driven by bigger and more efficient turbines, lower capital and operating costs, and other advancements.

    Little swirling mysteries: New research uncovers dynamics of ultrasmall, ultrafast groups of atoms

    Little swirling mysteries: New research uncovers dynamics of ultrasmall, ultrafast groups of atoms

    Exploring and manipulating the behavior of polar vortices in material may lead to new technology for faster data transfer and storage. Researchers used the Advanced Photon Source at Argonne and the Linac Coherent Light Source at SLAC to learn more.

    From Smoky Skies to a Green Horizon: Scientists Convert Fire-Risk Wood into Biofuel

    From Smoky Skies to a Green Horizon: Scientists Convert Fire-Risk Wood into Biofuel

    Reliance on petroleum fuels and raging wildfires: Two separate, large-scale challenges that could be addressed by one scientific breakthrough. Researchers from two national laboratories have collaborated to develop a streamlined and efficient process for converting woody plant matter like forest overgrowth and agricultural waste - material that is currently burned either intentionally or unintentionally - into liquid biofuel.

    Suppression of COVID-19 Waves Reflects Time-Dependent Social Activity, Not Herd Immunity

    Suppression of COVID-19 Waves Reflects Time-Dependent Social Activity, Not Herd Immunity

    Scientists developed a new mathematical model for predicting how COVID-19 spreads, accounting for individuals' varying biological susceptibility and levels of social activity, which naturally change over time.

    Plasma device designed for consumers can quickly disinfect surfaces

    Plasma device designed for consumers can quickly disinfect surfaces

    The COVID-19 pandemic has cast a harsh light on the urgent need for quick and easy techniques to sanitize and disinfect everyday high-touch objects such as doorknobs, pens, pencils, and personal protective gear worn to keep infections from spreading.

    Cybersecurity in the Blue Economy

    Cybersecurity in the Blue Economy

    More than two-thirds of the Earth's surface is covered by the oceans and seas. Over the next decade, these vast waters are expected to add $3 trillion to the global economy by generating electricity using marine renewable energy (MRE) devices. These "blue economy" technologies harness power across waves, tides, and currents that could reduce the carbon footprint from energy production and provide grid stability to remote coastal communities.

    The Scoop on Hyperloop

    The Scoop on Hyperloop

    PNNL researchers investigate innovative transportation system's impact on the electric grid

    Better solutions for making hydrogen may lie just at the surface

    Better solutions for making hydrogen may lie just at the surface

    A new study uncovers insight into a promising type of material for splitting water, perovskite oxides.

    The Spintronics Technology Revolution Could Be Just a Hopfion Away

    The Spintronics Technology Revolution Could Be Just a Hopfion Away

    A research team co-led by Berkeley Lab has created and observed quasiparticles called 3D hopfions at the nanoscale (billionths of a meter) in a magnetic system. The discovery could advance high-density, high-speed, low-power, yet ultrastable magnetic memory "spintronics" devices.


    • Filters

    • × Clear Filters

    Department of Energy to Provide $10 Million for Research on Data Reduction for Science

    Today, the U.S. Department of Energy (DOE) announced $10 million for foundational research to address the challenges of managing and processing the increasingly massive data sets produced by today's scientific instruments, facilities, and supercomputers in order to facilitate more efficient analysis.

    ORNL's Honeycutt, Horvath Named SME 2021 Outstanding Young Manufacturing Engineers

    ORNL's Honeycutt, Horvath Named SME 2021 Outstanding Young Manufacturing Engineers

    Andrew Honeycutt and Nick Horvath, machine tool researchers at Oak Ridge National Laboratory, have been selected to receive the 2021 Geoffrey Boothroyd Outstanding Young Manufacturing Engineer Award from SME, the professional manufacturing engineering association.

    Department of Energy to Provide $25 Million toward Development of a Quantum Internet

    Today the U.S. Department of Energy (DOE) announced a plan to provide $25 million for basic research toward the development of a quantum internet.

    Media Advisory - U.S. Secretary of Energy and Other Leading Experts Talk Preparation for the Effects of Climate Change

    Media Advisory - U.S. Secretary of Energy and Other Leading Experts Talk Preparation for the Effects of Climate Change

    The escalating effects of climate change are evident across our country, from the damaging 2020 western wildfire season to February's southern deep freeze. The need has never been greater for a national strategy that combines the long-term goal of a 100% clean energy future with immediate, science-driven actions to help all communities overcome the effects of climate change.

    Department of Energy to Provide $5 Million to Advance Workforce Development for High Energy Physics Instrumentation

    Today, the U.S. Department of Energy (DOE) announced plans to provide $5 million to support a DOE traineeship program to address workforce needs in high energy physics instrumentation.

    DOE Awards $110 Million to Small Businesses Pursuing Scientific, Clean Energy, and Climate Solutions

    The U.S. Department of Energy (DOE) today announced awards totaling $110 million for diverse small businesses working on scientific, clean energy, and climate solutions for the American people.

    Teachers Invited to Participate in Virtual Science Activities Night

    Teachers Invited to Participate in Virtual Science Activities Night

    Elementary and middle school teachers are invited to register now to participate in the annual Virginia Region II Teacher Night hosted by the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility on April 14, 2021. The fully virtual event will allow educators to see demonstrations of new methods for teaching physical science concepts and safely meet and interact with their colleagues, all while they pick up one recertification point from the comfort of their own homes. Advance registration is required, and the event is open to all upper elementary and middle school teachers of physical science.

    DOE Announces $29 Million for Ultramodern Data Analysis Tools

    The U.S. Department of Energy (DOE) today announced $29 million to develop new tools to analyze massive amounts of scientific information, including artificial intelligence, machine learning, and advanced algorithms.

    Argonne's 2021 Maria Goeppert Mayer Fellows bring new energy, promise to their fields

    Argonne's 2021 Maria Goeppert Mayer Fellows bring new energy, promise to their fields

    The Department of Energy's Argonne National Laboratory is proud to welcome five new FY21 Maria Goeppert Mayer Fellows to campus, each chosen for their incredible promise in their respective fields.

    DOE Announces $54 Million for Microelectronics Research to Power Next-Generation Technologies

    The U.S. Department of Energy (DOE) today announced up to $54 million in new funding for the agency's National Laboratories to advance basic research in microelectronics. Microelectronics are a fundamental building block of modern devices such as laptops, smartphones, and home appliances, and hold the potential to power innovative solutions to challenges like the climate crisis and national security.


    • Filters

    • × Clear Filters
    Harvesting Energy from Light using Bio-inspired Artificial Cells

    Harvesting Energy from Light using Bio-inspired Artificial Cells

    Scientists designed and connected two different artificial cells to each other to produce molecules called ATP (adenosine triphosphate).

    Engineering Living Scaffolds for Building Materials

    Engineering Living Scaffolds for Building Materials

    Bone and mollusk shells are composite systems that combine living cells and inorganic components. This allows them to regenerate and change structure while also being very strong and durable. Borrowing from this amazing complexity, researchers have been exploring a new class of materials called engineered living materials (ELMs).

    Excavating Quantum Information Buried in Noise

    Excavating Quantum Information Buried in Noise

    Researchers developed two new methods to assess and remove error in how scientists measure quantum systems. By reducing quantum "noise" - uncertainty inherent to quantum processes - these new methods improve accuracy and precision.

    How Electrons Move in a Catastrophe

    How Electrons Move in a Catastrophe

    Lanthanum strontium manganite (LSMO) is a widely applicable material, from magnetic tunnel junctions to solid oxide fuel cells. However, when it gets thin, its behavior changes for the worse. The reason why was not known. Now, using two theoretical methods, a team determined what happens.

    When Ions and Molecules Cluster

    When Ions and Molecules Cluster

    How an ion behaves when isolated within an analytical instrument can differ from how it behaves in the environment. Now, Xue-Bin Wang at Pacific Northwest National Laboratory devised a way to bring ions and molecules together in clusters to better discover their properties and predict their behavior.

    Tune in to Tetrahedral Superstructures

    Tune in to Tetrahedral Superstructures

    Shape affects how the particles fit together and, in turn, the resulting material. For the first time, a team observed the self-assembly of nanoparticles with tetrahedral shapes.

    Tracing Interstellar Dust Back to the Solar System's Formation

    Tracing Interstellar Dust Back to the Solar System's Formation

    This study is the first to confirm dust particles pre-dating the formation of our solar system. Further study of these materials will enable a deeper understanding of the processes that formed and have since altered them.

    Investigating Materials that Can Go the Distance in Fusion Reactors

    Investigating Materials that Can Go the Distance in Fusion Reactors

    Future fusion reactors will require materials that can withstand extreme operating conditions, including being bombarded by high-energy neutrons at high temperatures. Scientists recently irradiated titanium diboride (TiB2) in the High Flux Isotope Reactor (HFIR) to better understand the effects of fusion neutrons on performance.

    Better 3-D Imaging of Tumors in the Breast with Less Radiation

    Better 3-D Imaging of Tumors in the Breast with Less Radiation

    In breast cancer screening, an imaging technique based on nuclear medicine is currently being used as a successful secondary screening tool alongside mammography to improve the accuracy of the diagnosis. Now, a team is hoping to improve this imaging technique.

    Microbes are Metabolic Specialists

    Microbes are Metabolic Specialists

    Scientists can use genetic information to measure if microbes in the environment can perform specific ecological roles. Researchers recently analyzed the genomes of over 6,000 microbial species.


    Spotlight

    Graduate students gather virtually for summer school at PPPL
    Monday October 05, 2020, 04:45 PM

    Graduate students gather virtually for summer school at PPPL

    Princeton Plasma Physics Laboratory

    Virtual internships for physics students present challenges, build community
    Tuesday September 15, 2020, 04:35 PM

    Virtual internships for physics students present challenges, build community

    Princeton Plasma Physics Laboratory

    Blocking the COVID-19 Virus's Exit Strategy
    Monday August 31, 2020, 04:05 PM

    Blocking the COVID-19 Virus's Exit Strategy

    Brookhaven National Laboratory

    Summer Students Tackle COVID-19
    Monday August 31, 2020, 03:35 PM

    Summer Students Tackle COVID-19

    Brookhaven National Laboratory

    Graduate student at PPPL Ian Ochs wins top Princeton University fellowship
    Friday April 17, 2020, 05:25 PM

    Graduate student at PPPL Ian Ochs wins top Princeton University fellowship

    Princeton Plasma Physics Laboratory

    Barbara Garcia: A first-generation college student spends summer doing research at PPPL
    Tuesday September 24, 2019, 04:05 PM

    Barbara Garcia: A first-generation college student spends summer doing research at PPPL

    Princeton Plasma Physics Laboratory

    Argonne organization's scholarship fund blazes STEM pathway
    Tuesday September 17, 2019, 05:05 PM

    Argonne organization's scholarship fund blazes STEM pathway

    Argonne National Laboratory

    Brookhaven Lab, Suffolk Girl Scouts Launch Patch Program
    Friday September 13, 2019, 11:30 AM

    Brookhaven Lab, Suffolk Girl Scouts Launch Patch Program

    Brookhaven National Laboratory

    From an acoustic levitator to a
    Thursday September 12, 2019, 03:05 PM

    From an acoustic levitator to a "Neutron Bloodhound" robot, hands-on research inspires PPPL's summer interns

    Princeton Plasma Physics Laboratory

    Brookhaven Lab Celebrates the Bright Future of its 2019 Interns
    Friday August 30, 2019, 10:00 AM

    Brookhaven Lab Celebrates the Bright Future of its 2019 Interns

    Brookhaven National Laboratory

    PPPL apprenticeship program offers young people chance to earn while they learn high-tech careers
    Thursday August 01, 2019, 12:05 PM

    PPPL apprenticeship program offers young people chance to earn while they learn high-tech careers

    Princeton Plasma Physics Laboratory

    Creating a diverse pipeline
    Friday July 19, 2019, 01:05 PM

    Creating a diverse pipeline

    Princeton Plasma Physics Laboratory

    JSA Awards Graduate Fellowships for Research at Jefferson Lab
    Monday July 08, 2019, 03:00 PM

    JSA Awards Graduate Fellowships for Research at Jefferson Lab

    Thomas Jefferson National Accelerator Facility

    ILSAMP Symposium showcases benefits for diverse students, STEM pipeline
    Monday May 20, 2019, 12:05 PM

    ILSAMP Symposium showcases benefits for diverse students, STEM pipeline

    Argonne National Laboratory

    Integrating Scientific Computing into Science Curricula
    Monday May 13, 2019, 11:05 AM

    Integrating Scientific Computing into Science Curricula

    Brookhaven National Laboratory

    Students from Minnesota and Massachusetts Win DOE's 29th National Science Bowl(r)
    Monday April 29, 2019, 02:05 PM

    Students from Minnesota and Massachusetts Win DOE's 29th National Science Bowl(r)

    Department of Energy, Office of Science

    DOE's Science Graduate Student Research Program Selects 70 Students to Pursue Research at DOE Laboratories
    Friday April 12, 2019, 03:05 PM

    DOE's Science Graduate Student Research Program Selects 70 Students to Pursue Research at DOE Laboratories

    Department of Energy, Office of Science

    Young Women's Conference in STEM seeks to change the statistics one girl at a time
    Thursday March 28, 2019, 03:05 PM

    Young Women's Conference in STEM seeks to change the statistics one girl at a time

    Princeton Plasma Physics Laboratory

    Students team with Argonne scientists and engineers to learn about STEM careers
    Tuesday March 12, 2019, 05:05 PM

    Students team with Argonne scientists and engineers to learn about STEM careers

    Argonne National Laboratory

    Lynbrook High wins 2019 SLAC Regional Science Bowl competition
    Wednesday February 13, 2019, 02:05 PM

    Lynbrook High wins 2019 SLAC Regional Science Bowl competition

    SLAC National Accelerator Laboratory

    Equipping the next generation for a technological revolution
    Thursday January 24, 2019, 01:05 PM

    Equipping the next generation for a technological revolution

    Argonne National Laboratory

    Chemistry intern inspired by Argonne's real-world science
    Friday January 18, 2019, 05:05 PM

    Chemistry intern inspired by Argonne's real-world science

    Argonne National Laboratory

    Chasing a supernova
    Friday January 18, 2019, 04:05 PM

    Chasing a supernova

    Argonne National Laboratory

    Argonne intern streamlines the beamline
    Tuesday January 08, 2019, 02:05 PM

    Argonne intern streamlines the beamline

    Argonne National Laboratory

    Research on Light-Matter Interaction Could Lead to Improved Electronic and Optoelectronic Devices
    Thursday October 11, 2018, 04:00 PM

    Research on Light-Matter Interaction Could Lead to Improved Electronic and Optoelectronic Devices

    Rensselaer Polytechnic Institute (RPI)

    Innovating Our Energy Future
    Wednesday October 03, 2018, 07:05 PM

    Innovating Our Energy Future

    Oregon State University, College of Engineering

    Physics graduate student takes her thesis research to a Department of Energy national lab
    Tuesday October 02, 2018, 03:05 PM

    Physics graduate student takes her thesis research to a Department of Energy national lab

    University of Alabama at Birmingham

    Friday September 21, 2018, 01:05 PM

    "Model" students enjoy Argonne campus life

    Argonne National Laboratory

    Writing Code for a More Skilled and Diverse STEM Workforce
    Thursday September 06, 2018, 01:05 PM

    Writing Code for a More Skilled and Diverse STEM Workforce

    Brookhaven National Laboratory

    New graduate student summer school launches at Princeton Plasma Physics Laboratory
    Tuesday September 04, 2018, 11:30 AM

    New graduate student summer school launches at Princeton Plasma Physics Laboratory

    Princeton Plasma Physics Laboratory

    The Gridlock State
    Friday August 31, 2018, 06:05 PM

    The Gridlock State

    California State University (CSU) Chancellor's Office

    Meet Jasmine Hatcher and Trishelle Copeland-Johnson
    Friday August 31, 2018, 02:05 PM

    Meet Jasmine Hatcher and Trishelle Copeland-Johnson

    Brookhaven National Laboratory

    Argonne hosts Modeling, Experimentation and Validation Summer School
    Friday August 24, 2018, 11:05 AM

    Argonne hosts Modeling, Experimentation and Validation Summer School

    Argonne National Laboratory

    Students affected by Hurricane Maria bring their research to SLAC
    Wednesday August 22, 2018, 01:05 PM

    Students affected by Hurricane Maria bring their research to SLAC

    SLAC National Accelerator Laboratory

    Brookhaven Lab Pays Tribute to 2018 Summer Interns
    Wednesday August 22, 2018, 10:05 AM

    Brookhaven Lab Pays Tribute to 2018 Summer Interns

    Brookhaven National Laboratory

    Changing How Buildings Are Made
    Monday August 20, 2018, 12:05 PM

    Changing How Buildings Are Made

    Washington University in St. Louis

    CSUMB Selected to Host Architecture at Zero Competition in 2019
    Thursday August 16, 2018, 12:05 PM

    CSUMB Selected to Host Architecture at Zero Competition in 2019

    California State University, Monterey Bay

    Department of Energy Invests $64 Million in Advanced Nuclear Technology
    Friday July 20, 2018, 03:00 PM

    Department of Energy Invests $64 Million in Advanced Nuclear Technology

    Rensselaer Polytechnic Institute (RPI)

    Professor Miao Yu Named the Priti and Mukesh Chatter '82 Career Development Professor
    Thursday July 19, 2018, 05:00 PM

    Professor Miao Yu Named the Priti and Mukesh Chatter '82 Career Development Professor

    Rensselaer Polytechnic Institute (RPI)

    2018 RHIC & AGS Annual Users' Meeting: 'Illuminating the QCD Landscape'
    Tuesday July 03, 2018, 11:05 AM

    2018 RHIC & AGS Annual Users' Meeting: 'Illuminating the QCD Landscape'

    Brookhaven National Laboratory

    Argonne welcomes <em>The Martian</em> author Andy Weir
    Friday June 29, 2018, 06:05 PM

    Argonne welcomes The Martian author Andy Weir

    Argonne National Laboratory

    Creating STEM Knowledge and Innovations to Solve Global Issues Like Water, Food, and Energy
    Monday June 18, 2018, 09:55 AM

    Creating STEM Knowledge and Innovations to Solve Global Issues Like Water, Food, and Energy

    Illinois Mathematics and Science Academy (IMSA)

    Professor Emily Liu Receives $1.8 Million DoE Award for Solar Power Systems Research
    Friday June 15, 2018, 10:00 AM

    Professor Emily Liu Receives $1.8 Million DoE Award for Solar Power Systems Research

    Rensselaer Polytechnic Institute (RPI)

    Celebrating 40 years of empowerment in science
    Thursday June 07, 2018, 03:05 PM

    Celebrating 40 years of empowerment in science

    Argonne National Laboratory





    Showing results

    0-6 Of 2215