DOE News
    Doe Science news source
    The DOE Science News Source is a Newswise initiative to promote research news from the Office of Science of the DOE to the public and news media.
    • 2020-06-08 15:45:25
    • Article ID: 732588

    Scientists Marry Two Powerful Techniques to Pinpoint Locations of Individual Molecules in Their Cellular Neighborhoods

    Researchers expect the new method to answer fundamental questions in biology and materials science. First up: Images showing molecules that help guide cell division in bacteria.

    • Credit: Peter Dahlberg et al., PNAS, 8 June 2020

      With a technique called cryoelectron tomography, scientists can create detailed 3D images of cells, such as this Caulobacter bacterium, and highlight their components – in this case, the cell membranes (red and blue), protein shell (green), protein factories known as ribosomes (yellow) and storage granules (orange). But until now, smaller structures and individual molecules could not be identified and precisely located within these images. A new imaging technique developed at Stanford fills this gap, revealing small molecules that are not visible here.

    • Credit: Peter Dahlberg et al., PNAS, 8 June 2020

      Scientists thought a seemingly empty area at one end of this Caulobacter cell might hold two proteins involved in cell division. By labeling the proteins with fluorescent tags and then imaging those same samples with cryoelectron tomography, they were able to confirm this location and show exactly how the proteins were arranged.

    • Credit: Peter Dahlberg et al., PNAS, 8 June 2020

      A rotating 3D image of the seemingly empty pocket at one end of a Caulobacter cell now shows the precise locations of PopZ molecules. The pocket looks lumpy because it has been manually colored in to highlight the area where researchers thought the molecules might be, but couldn't identify directly in cryoelectron tomography.

    • Credit: Peter Dahlberg et al., PNAS, 8 June 2020

      The image at left shows the locations of two types of protein molecules, PopZ and SpmX, in a cryoelectron tomography image of a Caulobacter cell. At right, a diagram depicts how the proteins are arranged: SpmX is embedded in the cell’s inner membrane and protrudes into the cell’s cytoplasm, where it comes into direct contact with PopZ. These proteins work together during cell division.

    Scientists have married two of today’s most powerful microscopy techniques to make images that pinpoint, for the first time, the identities and precise locations of individual proteins within the detailed context of bacterial cells. This information is crucial for learning how protein molecules work together to organize cell division and carry out other important tasks, such as enabling microbes to sniff out food and danger.

    The new method has already unearthed new information about bacterial proteins and their nearby cellular neighborhoods. Researchers say it also has potential to answer fundamental questions about the molecular machinery of viruses, parasites, and processes like photosynthesis.

    “This is a big leap for biology, and I think there are many, many systems that will benefit from this kind of imaging,” said Stanford Professor Lucy Shapiro, whose research group participated in the study.

    The new hybrid method, called correlated imaging by annotation with single molecules, or CIASM (pronounced “chasm”), was developed by Peter Dahlberg, a postdoctoral researcher in the lab of Professor W. E. Moerner at Stanford University.

    It’s a variation on a technique called low temperature single-molecule microscopy, invented by Moerner three decades ago, which attaches glowing labels to molecules so they can be individually identified. This method underlies super-resolution fluorescence microscopy, the topic of Moerner’s 2014 Nobel Prize in Chemistry.

    What Dahlberg did was find a way to make this type of fluorescence imaging work at sub-freezing temperatures so the same samples could also be examined with cryogenic electron tomography (CET). CET uses streams of electrons to make 3D images of flash-frozen cells and their components at near-atomic resolution. Combining CET with the fluorescent imaging allows scientists to see the tagged molecules in the context of the surrounding cell, a crucial perspective for understanding their role in the cellular machinery.

    “We can label specific molecules of interest so that the light we see comes only from those molecules, and then we find where they are within about 10 nanometers, or billionths of a meter. This gives us a much more accurate picture of what’s going on,” Dahlberg said. “We have taken the ultra-precise snapshots provided by CET and added a little bit of color.”

    He added, “It is exciting to develop new imaging methods. When you are done, you get to take a step back and look at all the new questions you can attack.”

    With CIASM, the research team was able to pinpoint the locations of three types of proteins in high-resolution CET images of bacteria taken at the Department of Energy’s SLAC National Accelerator Laboratory. The results were reported in the Proceedings of the National Academy of Sciences today.

    “Every method has its advantages and disadvantages,“ Moerner said, “and this is a nice situation where we can combine two methods to learn more.”

    Finding order in a cellular soup

    Even in relatively simple bacterial cells, location is everything, said Saumya Saurabh, a postdoctoral researcher in Shapiro’s lab who played a leading role in the research.

    “People tend to think of bacteria as sacks of proteins with no organization,” he said. “But it turns out that’s not true, and in fact many of the molecules in bacteria are precisely located in both space and time. If they’re not in the right position, the cell dies. What Pete’s work is finally allowing us to do is look inside with molecular resolution and find out when and where these molecules are located with respect to each other.”

    Caulobacter crescentus, for instance, a well-studied species of freshwater bacteria, is known for dividing into two very different types of daughter cells: One swims freely, while the other forms a stalk and attaches to a surface. How each daughter cell gets what it needs to follow its unique path has been a longstanding mystery.

    Scientists had previously identified small areas at either end of the dividing cell that might contain proteins that play key roles in this lopsided cell division. One of the proteins, PopZ, is found at both ends of the dividing cell, while the other, SpmX (“Spam-X”) is found only in the half that will develop a stalk.

    For this study, Saurabh and graduate student Jiarui Wang labeled proteins in Caulobacter with fluorescent tags. Then Dahlberg froze these samples, performed single-molecule fluorescence imaging on them with the help of graduate student Annina Sartor, and took them to the Stanford-SLAC Cryo-EM facilities for CET imaging directed by Wah Chiu, a professor at Stanford and SLAC.

    Mapping a protein hangout

    The combined images not only confirmed that both proteins were in the areas scientists had suspected, but also revealed exactly how they were arranged: SpmX was embedded in the cell’s inner membrane and protruded into the cell’s interior, where it came into direct contact with PopZ.

    “The exact orientation of this protein complex has been debated over the last 12 years,” Saurabh said. “We were able to observe the protein partners with exquisite resolution. Now we have a very precise picture of how these proteins talk to each other in the cell.” 

    The team tested the accuracy of CIASM by using it to confirm the location of a protein called McpA that was known to be part of a chemoreceptor array in the bacteria. “Exquisitely sensitive proteins in this array serve as Caulobacter’s nose,” Saurabh said, “sensing the chemistry of the surrounding environment so they can move away from unpleasant things and move toward the glucose they eat.”

    The array appears as parallel black lines in CET images, and fluorescent tagging of the same images pinpointed the locations of individual McpA proteins within about 10 nanometers. 

    A detailed look at quantum dots

    In a separate, parallel study, published in Angewandte Chemie on April 24, the researchers used a similar technique to look at single quantum dots, with some surprising results. 

    Quantum dots ­are nanoscale crystals of semiconductor material that naturally fluoresce in colors determined by their size, shape and composition. These dots are used in research to label and track proteins and other biological materials, and have potential applications in future electronics, lighting, quantum computing, medical imaging and other areas. 

    In this study, the goal was to see how the finer structural details of individual dots were related to specific details of their optical properties, said Davis Perez, a PhD student in Moerner’s lab. 

    “We were able to see some surprising behaviors of the individual quantum dots – for instance, in their response to excitation with laser light,” he said. “But the most exciting aspect to me is that the method we developed to study quantum dots can also be used to study biological systems such as photosynthetic proteins, where energy is transferred between groups of proteins, and see how the photosynthetic machinery operates.” 

    Moerner said his lab is working with Chiu to pursue these challenges.

    “It is the early days of combining the two methods, and we are excited to explore more collaborations linking light and electrons,” Chiu said. “This hybrid imaging approach has the potential to uncover structures of molecular components involved in key biological processes in cells spanning all domains of life.”

    Fluorescence microscopy for this study was carried out in the Moerner lab at Stanford.

    The research was supported, in part, by the National Institute of General Medical Sciences and the Department of Energy Office of Science. The Stanford-SLAC Cryo-EM facilities are part of the CryoEM & Bioimaging Division of the Stanford Synchrotron Radiation Lightsource at SLAC. 

     



    SLAC is a vibrant multiprogram laboratory that explores how the universe works at the biggest, smallest and fastest scales and invents powerful tools used by scientists around the globe. With research spanning particle physics, astrophysics and cosmology, materials, chemistry, bio- and energy sciences and scientific computing, we help solve real-world problems and advance the interests of the nation.

    SLAC is operated by Stanford University for the U.S. Department of Energy’s Office of Science. The Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.

    X
    X
    X
    • Filters

    • × Clear Filters
    AI software enables real-time 3D printing quality assessment

    AI software enables real-time 3D printing quality assessment

    Oak Ridge National Laboratory researchers have developed artificial intelligence software for powder bed 3D printers that assesses the quality of parts in real time, without the need for expensive characterization equipment.

    A Shining Example of Nature Leading the Way

    A Shining Example of Nature Leading the Way

    From oil refining to automobile pollution-control devices to the bulk of pharmaceuticals, platinum-group metals are the go-to choice for facilitating chemical reactions. It's been that way for decades. But a new review article in the August 14 issue of the journal Science, led by first author Morris Bullock of Pacific Northwest National Laboratory, provides a road map toward greater use of Earth-abundant metals, which would reduce cost and environmental impact.

    UChicago scientists discover way to make quantum states last 10,000 times longer

    UChicago scientists discover way to make quantum states last 10,000 times longer

    Scientists discovered a simple modification that allows quantum systems to stay operational 10,000 times longer than previous systems.

    SLAC scientists invent low-cost emergency ventilator and share the design for free

    SLAC scientists invent low-cost emergency ventilator and share the design for free

    Researchers at the Department of Energy's SLAC National Accelerator Laboratory have invented an emergency ventilator that could help save the lives of patients suffering from COVID-19, the disease caused by novel coronavirus SARS-CoV-2.

    Scientists propose method for eliminating damaging heat bursts in fusion device

    Scientists propose method for eliminating damaging heat bursts in fusion device

    Researchers discover a technique for widening the windows of plasma current to enhance suppression of edge localized modes (ELMs) that can damage tokamak facilities.

    A team of international physicists join forces in hunt for sterile neutrinos

    A team of international physicists join forces in hunt for sterile neutrinos

    The MINOS+ and Daya Bay neutrino experiments combine results to produce most stringent test yet for the existence of sterile neutrinos.

    Explosive nuclear astrophysics

    Explosive nuclear astrophysics

    An international team has made a key discovery related to "presolar grains" found in some meteorites. This discovery has shed light on stellar explosions and the origin of chemical elements. It has also provided a new method for astronomical research.

    Aug. 2020 Science Snapshots

    Aug. 2020 Science Snapshots

    *Subtropical weather phenomenon likely to bring greater rainfall - and drought - by 2100 *A Q&A with scientist Bin Wang on how Berkeley Lab is helping cities prepare for a major shift in our transportation and grid sectors *Berkeley Lab founder, cyclotron inventor, and Nobel laureate Ernest Lawrence, honored with a Memorial Highway in his home state.

    New Science Behind Algae-based Flip-flops

    New Science Behind Algae-based Flip-flops

    UC San Diego researchers formulated polyurethane foams, made from algae oil, to meet commercial specifications for midsole shoes and the foot-bed of flip-flops. Their latest result, in a series of recent research publications, offers a complete solution to the plastics problem--at least for polyurethanes.

    Horizon31 startup licenses ORNL global communication system for drones

    Horizon31 startup licenses ORNL global communication system for drones

    Horizon31, LLC, of Knoxville, Tenn., has exclusively licensed a novel communication system that allows users to reliably operate unmanned vehicles such as drones from anywhere in the world using only an internet connection.


    • Filters

    • × Clear Filters
    Workshop aimed at encouraging women and minority students to consider careers in plasma physics goes online

    Workshop aimed at encouraging women and minority students to consider careers in plasma physics goes online

    A dozen undergraduate students spent the afternoon doing experiments aimed at teaching them some fundamentals about electromagnets through PPPL's Undergraduate Workshop in Plasma Physics.

    Wayne State receives DOE grant to develop catalysts for renewable energy generation

    Wayne State receives DOE grant to develop catalysts for renewable energy generation

    This research will focus on the development of efficient electrochemical systems for energy generation and storage. The proposed work will have a significant impact on the development of efficient energy conversion systems.

    Natalie Roe Named Berkeley Lab's Associate Director for Physical Sciences

    Natalie Roe Named Berkeley Lab's Associate Director for Physical Sciences

    Natalie Roe, who joined Lawrence Berkeley National Laboratory (Berkeley Lab) as a postdoctoral fellow in 1989 and has served as Physics Division director since 2012, has been named the Lab's Associate Laboratory Director (ALD) for the Physical Sciences Area. Her appointment was approved by the University of California. The announcement follows an international search.

    Brookhaven Lab Partners in New $40 M Research Center to Convert Sunlight to Liquid Fuels

    Brookhaven Lab Partners in New $40 M Research Center to Convert Sunlight to Liquid Fuels

    UPTON, NY--The U.S. Department of Energy (DOE) has announced $40M in funding over five years for a new research center aimed at developing hybrid photoelectrodes for converting sunlight into liquid fuels. Chemists from DOE's Brookhaven National Laboratory will be key partners in this effort, dubbed the Center for Hybrid Approaches in Solar Energy to Liquid Fuels (CHASE), which will be led by the University of North Carolina at Chapel Hill (UNC) and includes additional collaborators at Emory University, North Carolina State University, the University of Pennsylvania, and Yale.

    Fermilab scientist Laura Fields receives $2.5 million DOE award to study beams of shape-shifting ghost particles

    Fermilab scientist Laura Fields receives $2.5 million DOE award to study beams of shape-shifting ghost particles

    Laura Fields has won an Early Career Research Award from the Department of Energy to help physicists better understand the composition of neutrino beams used by Fermilab experiments. Her work will help gather and validate results that could shed light on why the universe consists of something rather than nothing.

    Summer Sundays Go Virtual

    Summer Sundays Go Virtual

    rookhaven Lab is moving its Summer Sunday program to an online format for 2020. Over three Sundays this summer, the Lab will host a series of live, virtual events for everyone to interact with the Lab in a new way. Each event will feature a guided tour of a Brookhaven Lab facility followed by a live Q&A with a panel comprised of the facility's scientists.

    Geothermal Brines Could Propel California's Green Economy

    Geothermal Brines Could Propel California's Green Economy

    Deep beneath the surface of the Salton Sea, a shallow lake in California's Imperial County, sits an immense reserve of critical metals that, if unlocked, could power the state's green economy for years to come. These naturally occurring metals are dissolved in geothermal brine, a byproduct of geothermal energy production. Now the race is on to develop technology to efficiently extract one of the most valuable metals from the brine produced by the geothermal plants near the Salton Sea: lithium.

    Magnum Venus Products licenses ORNL co-developed additive manufacturing technologies

    Magnum Venus Products licenses ORNL co-developed additive manufacturing technologies

    The Department of Energy's Oak Ridge National Laboratory has licensed two additive manufacturing-related technologies that aim to streamline and ramp up production processes to Knoxville-based Magnum Venus Products, Inc., a global manufacturer of fluid movement and product solutions for industrial applications in composites and adhesives.

    Berkeley Lab Part of Multi-Institutional Team Awarded $60M for Solar Fuels Research

    Berkeley Lab Part of Multi-Institutional Team Awarded $60M for Solar Fuels Research

    The Department of Energy has awarded $60 million to a new solar fuels initiative - called the Liquid Sunlight Alliance (LiSA) - led by Caltech in close partnership with Berkeley Lab. LiSA will build on the foundational work of the Joint Center for Artificial Photosynthesis (JCAP).

    Will Fox wins 2020 John Dawson Award for producing new insights into astrophysical shockwaves

    Will Fox wins 2020 John Dawson Award for producing new insights into astrophysical shockwaves

    Profile of PPPL winner of APS Dawson Award for outstanding achievement in plasma physics research.


    • Filters

    • × Clear Filters
    Harvesting Energy from Light using Bio-inspired Artificial Cells

    Harvesting Energy from Light using Bio-inspired Artificial Cells

    Scientists designed and connected two different artificial cells to each other to produce molecules called ATP (adenosine triphosphate).

    Engineering Living Scaffolds for Building Materials

    Engineering Living Scaffolds for Building Materials

    Bone and mollusk shells are composite systems that combine living cells and inorganic components. This allows them to regenerate and change structure while also being very strong and durable. Borrowing from this amazing complexity, researchers have been exploring a new class of materials called engineered living materials (ELMs).

    Excavating Quantum Information Buried in Noise

    Excavating Quantum Information Buried in Noise

    Researchers developed two new methods to assess and remove error in how scientists measure quantum systems. By reducing quantum "noise" - uncertainty inherent to quantum processes - these new methods improve accuracy and precision.

    How Electrons Move in a Catastrophe

    How Electrons Move in a Catastrophe

    Lanthanum strontium manganite (LSMO) is a widely applicable material, from magnetic tunnel junctions to solid oxide fuel cells. However, when it gets thin, its behavior changes for the worse. The reason why was not known. Now, using two theoretical methods, a team determined what happens.

    When Ions and Molecules Cluster

    When Ions and Molecules Cluster

    How an ion behaves when isolated within an analytical instrument can differ from how it behaves in the environment. Now, Xue-Bin Wang at Pacific Northwest National Laboratory devised a way to bring ions and molecules together in clusters to better discover their properties and predict their behavior.

    Tune in to Tetrahedral Superstructures

    Tune in to Tetrahedral Superstructures

    Shape affects how the particles fit together and, in turn, the resulting material. For the first time, a team observed the self-assembly of nanoparticles with tetrahedral shapes.

    Tracing Interstellar Dust Back to the Solar System's Formation

    Tracing Interstellar Dust Back to the Solar System's Formation

    This study is the first to confirm dust particles pre-dating the formation of our solar system. Further study of these materials will enable a deeper understanding of the processes that formed and have since altered them.

    Investigating Materials that Can Go the Distance in Fusion Reactors

    Investigating Materials that Can Go the Distance in Fusion Reactors

    Future fusion reactors will require materials that can withstand extreme operating conditions, including being bombarded by high-energy neutrons at high temperatures. Scientists recently irradiated titanium diboride (TiB2) in the High Flux Isotope Reactor (HFIR) to better understand the effects of fusion neutrons on performance.

    Better 3-D Imaging of Tumors in the Breast with Less Radiation

    Better 3-D Imaging of Tumors in the Breast with Less Radiation

    In breast cancer screening, an imaging technique based on nuclear medicine is currently being used as a successful secondary screening tool alongside mammography to improve the accuracy of the diagnosis. Now, a team is hoping to improve this imaging technique.

    Microbes are Metabolic Specialists

    Microbes are Metabolic Specialists

    Scientists can use genetic information to measure if microbes in the environment can perform specific ecological roles. Researchers recently analyzed the genomes of over 6,000 microbial species.


    Spotlight

    Graduate student at PPPL Ian Ochs wins top Princeton University fellowship
    Friday April 17, 2020, 05:25 PM

    Graduate student at PPPL Ian Ochs wins top Princeton University fellowship

    Princeton Plasma Physics Laboratory

    Barbara Garcia: A first-generation college student spends summer doing research at PPPL
    Tuesday September 24, 2019, 04:05 PM

    Barbara Garcia: A first-generation college student spends summer doing research at PPPL

    Princeton Plasma Physics Laboratory

    Argonne organization's scholarship fund blazes STEM pathway
    Tuesday September 17, 2019, 05:05 PM

    Argonne organization's scholarship fund blazes STEM pathway

    Argonne National Laboratory

    Brookhaven Lab, Suffolk Girl Scouts Launch Patch Program
    Friday September 13, 2019, 11:30 AM

    Brookhaven Lab, Suffolk Girl Scouts Launch Patch Program

    Brookhaven National Laboratory

    From an acoustic levitator to a
    Thursday September 12, 2019, 03:05 PM

    From an acoustic levitator to a "Neutron Bloodhound" robot, hands-on research inspires PPPL's summer interns

    Princeton Plasma Physics Laboratory

    Brookhaven Lab Celebrates the Bright Future of its 2019 Interns
    Friday August 30, 2019, 10:00 AM

    Brookhaven Lab Celebrates the Bright Future of its 2019 Interns

    Brookhaven National Laboratory

    PPPL apprenticeship program offers young people chance to earn while they learn high-tech careers
    Thursday August 01, 2019, 12:05 PM

    PPPL apprenticeship program offers young people chance to earn while they learn high-tech careers

    Princeton Plasma Physics Laboratory

    Creating a diverse pipeline
    Friday July 19, 2019, 01:05 PM

    Creating a diverse pipeline

    Princeton Plasma Physics Laboratory

    JSA Awards Graduate Fellowships for Research at Jefferson Lab
    Monday July 08, 2019, 03:00 PM

    JSA Awards Graduate Fellowships for Research at Jefferson Lab

    Thomas Jefferson National Accelerator Facility

    ILSAMP Symposium showcases benefits for diverse students, STEM pipeline
    Monday May 20, 2019, 12:05 PM

    ILSAMP Symposium showcases benefits for diverse students, STEM pipeline

    Argonne National Laboratory

    Integrating Scientific Computing into Science Curricula
    Monday May 13, 2019, 11:05 AM

    Integrating Scientific Computing into Science Curricula

    Brookhaven National Laboratory

    Students from Minnesota and Massachusetts Win DOE's 29th National Science Bowl(r)
    Monday April 29, 2019, 02:05 PM

    Students from Minnesota and Massachusetts Win DOE's 29th National Science Bowl(r)

    Department of Energy, Office of Science

    DOE's Science Graduate Student Research Program Selects 70 Students to Pursue Research at DOE Laboratories
    Friday April 12, 2019, 03:05 PM

    DOE's Science Graduate Student Research Program Selects 70 Students to Pursue Research at DOE Laboratories

    Department of Energy, Office of Science

    Young Women's Conference in STEM seeks to change the statistics one girl at a time
    Thursday March 28, 2019, 03:05 PM

    Young Women's Conference in STEM seeks to change the statistics one girl at a time

    Princeton Plasma Physics Laboratory

    Students team with Argonne scientists and engineers to learn about STEM careers
    Tuesday March 12, 2019, 05:05 PM

    Students team with Argonne scientists and engineers to learn about STEM careers

    Argonne National Laboratory

    Lynbrook High wins 2019 SLAC Regional Science Bowl competition
    Wednesday February 13, 2019, 02:05 PM

    Lynbrook High wins 2019 SLAC Regional Science Bowl competition

    SLAC National Accelerator Laboratory

    Equipping the next generation for a technological revolution
    Thursday January 24, 2019, 01:05 PM

    Equipping the next generation for a technological revolution

    Argonne National Laboratory

    Chemistry intern inspired by Argonne's real-world science
    Friday January 18, 2019, 05:05 PM

    Chemistry intern inspired by Argonne's real-world science

    Argonne National Laboratory

    Chasing a supernova
    Friday January 18, 2019, 04:05 PM

    Chasing a supernova

    Argonne National Laboratory

    Argonne intern streamlines the beamline
    Tuesday January 08, 2019, 02:05 PM

    Argonne intern streamlines the beamline

    Argonne National Laboratory

    Research on Light-Matter Interaction Could Lead to Improved Electronic and Optoelectronic Devices
    Thursday October 11, 2018, 04:00 PM

    Research on Light-Matter Interaction Could Lead to Improved Electronic and Optoelectronic Devices

    Rensselaer Polytechnic Institute (RPI)

    Innovating Our Energy Future
    Wednesday October 03, 2018, 07:05 PM

    Innovating Our Energy Future

    Oregon State University, College of Engineering

    Physics graduate student takes her thesis research to a Department of Energy national lab
    Tuesday October 02, 2018, 03:05 PM

    Physics graduate student takes her thesis research to a Department of Energy national lab

    University of Alabama at Birmingham

    Friday September 21, 2018, 01:05 PM

    "Model" students enjoy Argonne campus life

    Argonne National Laboratory

    Writing Code for a More Skilled and Diverse STEM Workforce
    Thursday September 06, 2018, 01:05 PM

    Writing Code for a More Skilled and Diverse STEM Workforce

    Brookhaven National Laboratory

    New graduate student summer school launches at Princeton Plasma Physics Laboratory
    Tuesday September 04, 2018, 11:30 AM

    New graduate student summer school launches at Princeton Plasma Physics Laboratory

    Princeton Plasma Physics Laboratory

    The Gridlock State
    Friday August 31, 2018, 06:05 PM

    The Gridlock State

    California State University (CSU) Chancellor's Office

    Meet Jasmine Hatcher and Trishelle Copeland-Johnson
    Friday August 31, 2018, 02:05 PM

    Meet Jasmine Hatcher and Trishelle Copeland-Johnson

    Brookhaven National Laboratory

    Argonne hosts Modeling, Experimentation and Validation Summer School
    Friday August 24, 2018, 11:05 AM

    Argonne hosts Modeling, Experimentation and Validation Summer School

    Argonne National Laboratory

    Students affected by Hurricane Maria bring their research to SLAC
    Wednesday August 22, 2018, 01:05 PM

    Students affected by Hurricane Maria bring their research to SLAC

    SLAC National Accelerator Laboratory

    Brookhaven Lab Pays Tribute to 2018 Summer Interns
    Wednesday August 22, 2018, 10:05 AM

    Brookhaven Lab Pays Tribute to 2018 Summer Interns

    Brookhaven National Laboratory

    Changing How Buildings Are Made
    Monday August 20, 2018, 12:05 PM

    Changing How Buildings Are Made

    Washington University in St. Louis

    CSUMB Selected to Host Architecture at Zero Competition in 2019
    Thursday August 16, 2018, 12:05 PM

    CSUMB Selected to Host Architecture at Zero Competition in 2019

    California State University, Monterey Bay

    Department of Energy Invests $64 Million in Advanced Nuclear Technology
    Friday July 20, 2018, 03:00 PM

    Department of Energy Invests $64 Million in Advanced Nuclear Technology

    Rensselaer Polytechnic Institute (RPI)

    Professor Miao Yu Named the Priti and Mukesh Chatter '82 Career Development Professor
    Thursday July 19, 2018, 05:00 PM

    Professor Miao Yu Named the Priti and Mukesh Chatter '82 Career Development Professor

    Rensselaer Polytechnic Institute (RPI)

    2018 RHIC & AGS Annual Users' Meeting: 'Illuminating the QCD Landscape'
    Tuesday July 03, 2018, 11:05 AM

    2018 RHIC & AGS Annual Users' Meeting: 'Illuminating the QCD Landscape'

    Brookhaven National Laboratory

    Argonne welcomes <em>The Martian</em> author Andy Weir
    Friday June 29, 2018, 06:05 PM

    Argonne welcomes The Martian author Andy Weir

    Argonne National Laboratory

    Creating STEM Knowledge and Innovations to Solve Global Issues Like Water, Food, and Energy
    Monday June 18, 2018, 09:55 AM

    Creating STEM Knowledge and Innovations to Solve Global Issues Like Water, Food, and Energy

    Illinois Mathematics and Science Academy (IMSA)

    Professor Emily Liu Receives $1.8 Million DoE Award for Solar Power Systems Research
    Friday June 15, 2018, 10:00 AM

    Professor Emily Liu Receives $1.8 Million DoE Award for Solar Power Systems Research

    Rensselaer Polytechnic Institute (RPI)

    Celebrating 40 years of empowerment in science
    Thursday June 07, 2018, 03:05 PM

    Celebrating 40 years of empowerment in science

    Argonne National Laboratory

    Introducing Graduate Students Across the Globe to Photon Science
    Monday May 07, 2018, 10:30 AM

    Introducing Graduate Students Across the Globe to Photon Science

    Brookhaven National Laboratory

    Students from Massachusetts and Washington Win DOE's 28th National Science Bowl(r)
    Wednesday May 02, 2018, 04:05 PM

    Students from Massachusetts and Washington Win DOE's 28th National Science Bowl(r)

    Department of Energy, Office of Science

    The Race for Young Scientific Minds
    Thursday April 12, 2018, 07:05 PM

    The Race for Young Scientific Minds

    Argonne National Laboratory

    Q&A: Al Ashley Reflects on His Efforts to Diversify SLAC and Beyond
    Wednesday March 14, 2018, 02:05 PM

    Q&A: Al Ashley Reflects on His Efforts to Diversify SLAC and Beyond

    SLAC National Accelerator Laboratory





    Showing results

    0-4 Of 2215