Scientists identify genetic basis of Alagille syndrome
Children's Hospital of PhiladelphiaA report in the July report of Nature Genetics offers new hope for families affected with the genetic disorder Alagille syndrome. Nancy Spinner, Ph.D., and a team of geneticists at The Children's Hospital of Philadelphia have demonstrated that mutations in a gene dubbed "Jagged 1" are responsible for the developmental disorder, which affects structures in the liver, heart, skeleton, eye, face, kidney and other organs.