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Mannose’s Unexpected Effects on the Microbiome and Weight Gain

Scientists continue to unravel links between body weight and the gut microbiome. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP) report an unexpected finding: mice fed a fatty diet and mannose, a sugar, were protected...
18-Sep-2018 11:00 AM EDT Add to Favorites

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Solving the Gut Inflammation Puzzle

Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders—including ulcerative colitis and Crohn’s disease—remains a clinical challenge. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), in...
17-Sep-2018 3:30 PM EDT Add to Favorites

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Malicious Brain Cell Identified

Astrocytes' important role in brain function suggests they are also involved in disease. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified an astrocyte subpopulation as the dominant cell type to spring into...
13-Sep-2018 1:00 PM EDT Add to Favorites

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An Old Drug Finds New Purpose Against Retinal Neovascularization

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, wet age-related...
12-Sep-2018 2:00 PM EDT Add to Favorites

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Shedding Light on 100-Year-Old Cancer Mystery

Using genetic and pharmacological means, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) were surprised to find that blocking LDHA had only a limited impact on melanoma cells, since they were able to redirect energy...
11-Sep-2018 12:00 PM EDT Add to Favorites

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Sarcolipin Tricks Muscle Cells into Using More Energy, Burning Fat

Ever wonder why you burn fat and heat up when you exercise or shiver? Now, researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that sarcolipin, a small peptide only found in muscles, increases muscle energy expenditure...
10-Sep-2018 2:50 PM EDT Add to Favorites

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Duchenne Muscular Dystrophy: How Muscle Cells Journey to the Dark Side

Answers to treating muscular dystrophies could lie in better understanding muscle repair—which resembles a delicate cellular dance choreographed by special cells called fibro-adipogenic progenitors (FAPs). Researchers already know these cells have...
11-Sep-2018 8:00 AM EDT Add to Favorites

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Breast Cancer Researcher Svasti Haricharan Joins SBP Faculty

Breast cancer researcher Svasti Haricharan joins SBP faculty
31-Aug-2018 8:00 AM EDT Add to Favorites


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Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent nonprofit medical research organization that conducts world-class, collaborative, biological research and translates its discoveries for the benefit of patients. SBP focuses its research on cancer, immunity, neurodegeneration, metabolic disorders and rare children’s diseases. The Institute invests in talent, technology and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs about 975 scientists and staff in San Diego (La Jolla), Calif., and Orlando (Lake Nona), Fla. For more information, visit us at SBPdiscovery.org or on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.

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