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First map of proinsulin’s “social network” reveals new drug target for type 2 diabetes

Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin. The study, published in Diabetes, also...
27-May-2020 8:00 AM EDT Add to Favorites

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Scientists identify promising immunotherapy combination for pediatric brain cancer

Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected...
15-May-2020 12:50 PM EDT Add to Favorites

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Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain...
11-May-2020 12:45 PM EDT Add to Favorites

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Sanford Burnham Prebys to develop broad-spectrum antivirals with $10 million Department of Defense grant

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that Sumit Chanda, Ph.D., has received a $10.2 million, four-year grant from the Department of Defense to develop and advance broad-spectrum antivirals for respiratory...
8-May-2020 2:10 PM EDT Add to Favorites

Researchers use live virus to identify 30 existing drugs that could treat COVID-19

Scientists at Sanford Burnham Prebys Medical Discovery Institute, the University of Hong Kong, Scripps Research, UC San Diego School of Medicine, the Icahn School of Medicine at Mount Sinai and UCLA have identified 30 existing drugs that stop the...
20-Apr-2020 8:25 AM EDT Add to Favorites

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Pancreatic cancer blocked by disrupting cellular pH balance

Scientists at Sanford Burnham Prebys have found a new way to kill pancreatic cancer cells by disrupting their pH equilibrium. The study, published in Cancer Discovery, reports how depleting an ion transport protein lowers the pH to a point that...
3-Apr-2020 1:50 PM EDT Add to Favorites

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Sanford Burnham Prebys Medical Discovery Institute welcomes new trustees Karen Haynes and Donald Kearns

Sanford Burnham Prebys Medical Discovery Institute today announced that Karen Haynes, Ph.D., president emerita at California State University San Marcos, and Donald Kearns, M.D., president emeritus at Rady Children’s Hospital-San Diego, have been...
24-Feb-2020 8:00 AM EST Add to Favorites

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A deep dive into cellular aging

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Harvard University have discovered that mitochondria trigger senescence, the sleep-like state of aged cells, through communication with the cell’s nucleus—and identified an...
18-Feb-2020 5:10 PM EST Add to Favorites


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Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities. For more information, visit us at SBPdiscovery.org or on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.

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