Researchers at Dana-Farber Cancer Institute and Columbia University have obtained the first detailed, three-dimensional picture of the lock-and-key mechanism by which HIV-1 binds to blood cells -- a milestone in the effort to develop AIDS vaccines that are effective against many strains of the virus.
In experiments with mice, researchers at Dana-Farber Cancer Institute and Children's Hospital (Boston) have used a naturally occurring protein to thwart one of the most common -- and potentially lethal -- complications associated with bone marrow transplants.
In an unexpected spin-off of cancer research that began more than a decade ago, scientists at Dana-Farber Cancer Institute have succeeded in reducing atherosclerosis - hardening of the arteries - by 80 percent in mice by blocking a gene in mice that is virtually identical to one in humans.
The "International Conference on the Prevention and Early Diagnosis of Lung Cancer" today release an unanimously agreed upon statement calling for the need to address screening and early detection of lung cancer.
In a study that confirms warnings issued by researchers four years ago, the same researchers now report that both infant and adult monkeys vaccinated with a live, weakened form of an HIV-like virus have developed AIDS from the vaccine virus itself.
In a study that points the way to a new form of cancer therapy, researchers at Dana-Farber Cancer Institute and Harvard Medical School report that a drug commonly used to treat diabetes has caused tumor cells to shift to a slower-growing, less-menacing state in patients with a rare type of cancer.
Scientists at Dana-Farber Cancer Institute and Duke University Medical Center have uncovered a new portion of the circuitry that controls the natural death of cells, they published in the April 23 issue of Science.
In a pair of studies that promise to rewrite scientists' understanding of genetic "tripwires" that kill cells before they become fully cancerous, researchers at Dana-Farber Cancer Institute have found that the same system that protects against cancer can, in some circumstances, actually promote cells on the road toward malignancy.
Women who begin alternative medical therapies in the wake of a breast cancer diagnosis exhibit greater psychosocial distress, according to a study by researchers at Dana-Farber Cancer Institute and Harvard Medical School published in the June 3rd issue of the New England Journal of Medicine.
In a study with powerful implications for people needing organ and tissue transplants, researchers at Dana-Farber Cancer Institute and Harvard Medical School have devised a new technique that may make transplants available to nearly everyone with a partially matched donor.
A two-drug therapy that artificially rebuilds the cell's quality-control system can completely destroy human tumor cells grown in laboratory animals, researchers at Dana-Farber Cancer Institute report in the Nov. 9 issue of the Proceedings of the National Academy of Sciences.
The first detailed pictures of key immune system cells locked onto fragments of a foreign substance provide new clues about how the immune system identifies enemy threats and may even lead to a novel way of vaccinating people against diseases to which they are genetically susceptible.
It may be possible to protect infants from acquiring the HIV virus during birth by giving them and their mothers a combination of three potent human antibodies shortly before delivery and after birth (Nature Medicine, 2-00).
For pediatric cancer patients, the primary goal of treatment is often to cure; the toxicity of the therapy or the patient's quality of life is often secondary to this goal (New England Journal of Medicine, 2-3-00).
The trigger for cirrhosis of the liver may be the erosion of tiny, repetitive DNA strands called telomeres that cover the tips of chromosomes and limit the number of times cells may divide, according to Dana-Farber Cancer Institute researchers (Science, 2-18-00).
Researchers at Dana-Farber have developed a new method of isolating specific proteins; the transmembrane proteins "G-protein-coupled receptors" in the Farber study represent one of the most promising targets for new drug therapies.
Edward J. Benz, Jr., an internationally recognized hematologist, has been named the next president of the Dana-Farber Cancer Institute. Benz is currently chair of the Department of Medicine at Johns Hopkins University School of Medicine.
Evidence for a theory of why incidences of certain cancers grow more common as people age is offered by researchers at Dana-Farber Cancer Institute (Nature, 8-10-00).
Endostatin, a drug that seeks to reduce tumors by cutting off their blood supply, appears to be safe and well-tolerated, according to preliminary results on 19 people studied in Boston.
There is considerable delay among parents in recognizing when children with advanced cancer have no realistic chance of cure, according to a Dana-Farber Cancer Institute and ChildrenÃÂs Hospital-Boston study published in the November 15 issue of JAMA.
With sinister efficiency, retroviruses such as HIV use only a small portion of their genetic programming to steal away from the cell where they were born and infect other cells. A new study provides details of how retroviruses make their escape and cloak themselves in the cellÃÂs membrane to avoid attack from the bodyÃÂs immune system. (Proceedings of the National Academy of Sciences, 11-21-00)
Dana-Farber Cancer Institute has opened its new Zakim Center for Integrated Therapies. In addition to conducting clinical trials to study the safety and effectiveness of complementary therapies, physicians and researchers will create an array of research programs to increase patient and medical staff knowledge of these therapies.
In a study reflecting the growing interest in the long-term effects of cancer treatment, researchers at Dana-Farber Cancer Institute and Children's Hospital, Boston, have found that boys treated with high doses of chemotherapy are likely to experience fertility problems as adults. (Cancer, 2-1-01)
Following the gene trail of a rare disease, scientists have discovered a new pathway to BRCA1, a gene that, when defective, is the most common source of inherited breast cancer. Two studies by Dana-Farber researchers show how genes involved in a condition called Fanconi anemia form a pathway to the activation of BRCA1. (Molecular Cell, 2-16-01)
Patients with leukemia, lymphoma and other cancers who choose to undergo bone marrow transplantation often overestimate the success rate of the procedure. (JAMA, 2-28-01)
A drug that made national headlines for its success against chronic myelogenous leukemia has shrunk and even eliminated some tumors in a patient with a rare and otherwise incurable form of gastrointestinal cancer. (NEJM, 4-5-01)
An international team of researchers report that a drug approved by the U.S. Food and Drug Administration last week for its striking success against chronic myelogenous leukemia (CML) can also benefit the majority of patients with a rare and otherwise incurable form of gastrointestinal cancer.
Using a form of counseling aimed at motivating rather than preaching, researchers at Dana-Farber Cancer Institute helped smokers reduce by nearly one-third the amount of dangerous second-hand smoke their young children were exposed to, according to a new study.
Dana-Farber Cancer Institute and the University of Massachusetts Lowell announced a new national partnership between labor unions and tobacco control groups to reduce tobacco use and exposure to secondhand smoke among working families.
New, three-dimensional images from researchers at Dana-Farber Cancer Institute provide the fullest picture yet of how the AIDS virus blunts the immune system's ability to mount an attack against infections and cancer.
Dana-Farber Cancer Institute researchers have discovered the long-sought molecular "switch" that regulates the liver's production of glucose, the sugar that fuels the brain but which builds up dangerously in the bloodstream of diabetics because this switch doesn't turn off. Researchers say it may be possible to design new drug treatments for diabetes as a result of the work.
By manipulating a cell that controls the immune system's response to infections, researchers at Dana-Farber Cancer Institute and their colleague have prevented the onset of diabetes in mice predisposed to the disease. The finding one day may lead to the development of a preventive therapy for people at risk for type 1 diabetes.
Using miniaturized chips that make snapshots of the activity of thousands of genes at once, Dana-Farber Cancer Institute scientists have divided lung cancers into new categories based on their gene functions rather than the cells' appearance under a microscope.
While most cancer patients enrolled in clinical trials understand the primary purpose of the research, nearly one quarter of the participants do not realize that clinical trials are conducted mainly to benefit future patients, not themselves.
Dana-Farber Cancer Institute scientists have discovered that a rare but lethal blood cancer that strikes infants in their first year is a genetically distinct type of leukemia that might someday be treatable with designer drugs specifically targeted to it.
1) Study upends earlier thinking about immune cells' readiness against disease; 2) Drawing a new map of cancer: gene chips help sort out cancer types; 3) Researchers to examine disparity in cancer care among minorities.
Dana-Farber researchers have developed a powerful method for detecting foreign bacteria and viruses in human tissue samples, even if the organisms haven't previously been encountered. The microbe-hunting method relies on DNA sequence data.
1) Social influences in the workplace contribute to occupational differences in quitting smoking; 2) Childhood cancer patients find survival is the first step in lifelong battle.
People who have a parent or sibling with colon cancer can markedly reduce their own chances of developing the disease by taking a daily multivitamin that includes folic acid and limiting their intake of alcohol, per a Dana-Farber, Brigham and Women's, and HSPH study.
Dana-Farber researchers have identified the underlying mechanism that causes one of tamoxifen's side effects. The findings may lead to new medications that reduce the risk of certain types of breast cancer, but don't carry tamoxifen's potential downside.
Many young women treated with chest radiation for Hodgkin's disease are not aware that they have an increased risk of developing breast cancer later in life. Moreover, among those who are aware of their increased risk, many fail to have regular mammograms, according to a new study led by researchers at Dana-Farber Cancer Institute.
A decade of research into one of the world's least-known diseases has resulted in a major advance against one of the best-known: the discovery of six genes linked to inherited breast cancer. Dana-Farber Cancer Institute researchers and colleagues report that an error in any of six Fanconi anemia genes can increase a person's risk of developing breast cancer.
An international study questions the value of chemotherapy following breast surgery in postmenopausal women with lymph node-negative tumors that are responsive to estrogen. However, patients whose tumors were unresponsive to estrogen did benefit from chemotherapy.
Blue-collar workers are more likely to quit smoking when workplace smoking cessation programs are combined with other occupational health and safety messages rather than when singled out, according to a study headed by Dana-Farber Cancer Institute researchers. The findings may lead to a new approach to improving working-class people's health.
Research has shown that a diet high in starchy foods may increase the risk of pancreatic cancer in women who are overweight and sedentary. The study suggests that excess insulin can promote the development of pancreatic cancer.
A study led by researchers at Dana-Farber Cancer Institute has shown that a drug extracted from porcine intestinal tissue reduced the risk of death in patients who experienced severe veno-occlusive disease, an often-fatal complication of stem cell transplants.
Dana-Farber researchers have made a discovery that could help explain how a child's sunburn can develop into a deadly tumor decades later. The findings may lead to a means of distinguishing, at an early stage, cancerous moles from non-cancerous ones.
In a demonstration of a vaccine therapy's potential for treating lung cancer, Dana-Farber Cancer Institute scientists report that a prototype vaccine boosted the natural immune response to tumors in a small group of patients with advanced non-small cell lung cancer.
A multi-institutional study has shown that adding two experimental drugs to the standard four-drug chemotherapy regimen significantly improved survival in patients with non-metastatic Ewing's sarcoma, a highly malignant bone cancer of children and young adults.
A relatively brief screening test can give caregivers a good indication of which cancer survivors are emotionally distressed and may benefit from further psychological evaluation, according to new research by a team of Dana-Farber Cancer Institute investigators.
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