Released: 14-Jul-2006 9:00 AM EDT
New Foundation to Kick Italian Science to Soccer Heights
Sbarro Health Research Organization (SHRO)

The Human Health Foundation (HHF), a nonprofit organization designed to develop and fund biomedical research in Italy will be introduced on July 15th during this year's annual Spoleto Festival by Antonio Giordano, MD, PhD, president and founder of the Sbarro Health Research Organization (www.shro.org).

Released: 21-Feb-2007 6:00 AM EST
Roche Diagnostics and Sbarro Health Research Organization Join Forces
Sbarro Health Research Organization (SHRO)

Roche Diagnostics and Sbarro Health Research Organization link to provide enhanced bio-medical research.

Released: 1-Mar-2007 9:05 AM EST
Otvos Article One of Most Cited in 2006
Sbarro Health Research Organization (SHRO)

Laszlo Otvos, Jr.,MD, research professor and director of Drug Development for Sbarro Institute of Cancer Research and Molecular Medicine, is recognized for writing a "Most Cited: 2006" paper according to ACS Publications.

Released: 24-Aug-2007 1:00 AM EDT
Forced Expression of Brg1 Tips the Balance in Stem Cell Cycles
Sbarro Health Research Organization (SHRO)

Scientists have known that it takes combinations of chromatin remodeling factors to keep the processes of self-renewal, proliferation and differentiation of stem cells in proper balance. Now, researchers have discovered that forced expression of chromatin remodeling factor Brg1 induces cell cycle arrest, death and deterioration in mesenchymal stem cells (MSCs), upsetting this delicate harmony.

Released: 11-Jan-2008 8:00 AM EST
Digi S Lab Opens on Second Life
Sbarro Health Research Organization (SHRO)

Sbarro Health Research Organization will be one of the first groups to use Virtual Lab on the futuristic world of Second Life. The Lab will one day help train young scientists in research procedures and protocols with state of the art lab equipment.

   
Released: 20-Mar-2008 9:00 AM EDT
Novel Approach May Spell Safer Gene Therapy
Sbarro Health Research Organization (SHRO)

Professor Claudio Napoli, a Full Professor at the II University of Naples and Adjunct Professor at the Sbarro Research Institute for Cancer Research and Molecular Medicine in the College of Science and Technology of Temple University, is part of a multicenter team presenting a novel strategy for circumventing safety problems that have plagued gene therapy.

Released: 25-Jun-2008 9:00 AM EDT
Cdk9-55 May Induce Muscle Regeneration in Damaged and Healthy Tissues
Sbarro Health Research Organization (SHRO)

The role played by the protein cdk9-55 in muscle regeneration and differentiation may lead to new therapies to rebuild muscle tissue damaged by disease, injury, and aging, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and at the University of Siena, Italy.

Released: 3-Sep-2008 8:45 AM EDT
International Team Reveals First Prognosticator of Survival in Aggressive Cancer
Sbarro Health Research Organization (SHRO)

The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers.

Released: 7-Jan-2009 6:00 AM EST
Gene Marker May Improve Odds of Stem Cell Therapies for Disease
Sbarro Health Research Organization (SHRO)

A single tumor-suppressor gene may provide a unique marker for senescence in Mesenchymal stem cells (MSCs) in vitro, while also playing a role in moving MSCs into senescence, researchers at the Human Health Foundation and the Sbarro Institute for Cancer Research and Molecular Medicine report.

Released: 27-Jan-2009 5:00 AM EST
Researchers Locate Two New Potential Targets for Pediatric Tumor Treatments
Sbarro Health Research Organization (SHRO)

Researchers have tagged two new potential targets for treating rhabdomyosarcoma (RMS) -- a highly malignant pediatric tumor thought to arise from mesenchymal stem cells (MSCs) committed to become skeletal muscle cells.

Released: 24-Mar-2009 7:00 AM EDT
AIDS Drug May Restrict Proliferation of Cancer Cells
Sbarro Health Research Organization (SHRO)

The clinically approved AIDS drug ABC (Abacavir) can reduce proliferation and induce differentiation of human medulloblastoma cells through the downregulation of telomerase activity, which may make it an effective therapeutic strategy for the treatment of the highly malignant primary brain tumors, according to research published in the International Journal of Cancer.

29-Jun-2009 5:00 AM EDT
Rate of Breast Cancer in Italy Significantly Higher than Previously Reported
Sbarro Health Research Organization (SHRO)

A new analysis of the incidence of breast cancer in Italy per 100,000 women between the ages of 0 to 84 from 2000 to 2005 shows a 72 percent spike above official estimates issued by the Ministry of Health, with the sharpest uptick of +28.6 percent found in the youngest group studied (ages 25 to 44).

Released: 3-Jul-2009 6:00 AM EDT
Cell Cycle Kinases as Therapeutic Targets for Cancer
Sbarro Health Research Organization (SHRO)

A featured article in the July 2009 online issue of Nature Reviews/Drug Discovery that explores the prospects and progress of synthetic inhibitors to target cell cycle kinases in cancer forecasts that "novel compounds with increased potency, improved kinase specificity and favorable drug like properties will soon be available for clinical evaluation."

Released: 28-Aug-2009 6:00 AM EDT
Sponsor-A-Scientist: New Option to Fund Biomedical Research
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization, a nonprofit center for cancer, cardiovascular and diabetes research located at Temple University in Philadelphia and the University of Siena, Italy, has launched Sponsor-A-Scientist, an innovative program that allows interested individuals to bid on e-Bay for a named fellowship to support a talented young scientist for one academic year.

Released: 9-Oct-2009 7:00 AM EDT
Columbus Cancer Foundation Honors Legendary Explorer
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization at Temple University has launched the Columbus Cancer Foundation, a nonprofit organization that will raise funds for joint American and European educational initiatives, basic and clinical cancer research and international scientific collaboration.

Released: 27-Oct-2009 12:30 PM EDT
Sbarro Health Research Organization Opens New Biotechnology Research Center
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization (SHRO), a nonprofit research facility located at Temple University, will dedicate a new state-of-the-art biotechnology research center on Tuesday, October 27th, at 2 p.m. SHRO is one of the top three international laboratories, based on number of publications as ranked by the Cell Cycle Registry,

Released: 22-Jan-2010 7:00 AM EST
Possible New Heritable Marker for Retinoblastoma: Findings May Suggest New Targets and Treatments for Childhood Cancer
Sbarro Health Research Organization (SHRO)

Researchers working at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia, PA and at the University of Siena in Siena, Italy, have shed light on the possible role of inactivation of the 16INK4A gene in the progression of retinoblastoma.

Released: 22-Jan-2010 7:00 AM EST
Aging Stem Cells: New Study Sheds Light on Senescence Process
Sbarro Health Research Organization (SHRO)

Researchers from the Sbarro Institute for Molecular Medicine and Cancer Research at Temple University in Philadelphia and the Human Health Foundation in Spoleto, Italy, have found that MECP2, a gene that modifies the chromatin in the cell, has an important role in stem cell aging.

Released: 6-Apr-2010 7:00 AM EDT
New Pyrimidine Compounds May Lead to Improved Treatments for Childhood Brain Cancer
Sbarro Health Research Organization (SHRO)

Src (short for sarcoma) is a family of proto-oncogenic tyrosine kinases active in many cancer tumors, including medulloblastoma, the most common malignant cancer in children. A recent study shows that pyrazolo-[3,4-d]–pyrimidine-derivatives, designed to target Src, may be effective in interfering with the cell cycle and causing cancer cell death in medulloblastoma.

Released: 4-Jun-2010 9:00 AM EDT
First Human Health Foundation Research Lab To Open in Terni, Italy
Sbarro Health Research Organization (SHRO)

The Human Health Foundation (HHF), a nonprofit organization founded in 2006 to develop and fund biomedical research in Italy, will open its first bioscience laboratory for the investigation of breast, brain and lung cancer on June 7th in Terni, Italy.

Released: 21-Jul-2010 7:00 AM EDT
Increases in Leptin May Promote Colorectal Cancer
Sbarro Health Research Organization (SHRO)

While researchers have known that obesity increases the risk for the development of colon cancer, the underlying molecular mechanisms have remained unclear. Now, for the first time, a collaborative study of researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University’s College of Science and Technology and the Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy have found that an increase in leptin, a cytokine that is normally increased in obese or overweight individuals, may promote colorectal neoplasms by activating colorectal cancer stem cells.

Released: 22-Oct-2010 9:00 AM EDT
Metabolic Syndrome Affects Breast Cancer Risk in Postmenopausal Women
Sbarro Health Research Organization (SHRO)

Metabolic syndrome, associated with the sedentary lifestyle and energy dense diet of Western industrialized societies, may be an indicator of breast cancer risk in post-menopausal women, according to a new study to be released at the National Italian American Foundation event, “Let’s Talk About It: A Spotlight on Women’s Health” on October 22nd at the Washington Hilton in Washington, D.C.

Released: 25-Feb-2011 7:00 AM EST
Study Uncovers Mechanisms that Control Rb2/p130 Gene Expression in Lung Cancer
Sbarro Health Research Organization (SHRO)

A new study uncovers mechanisms that control Rb2/p130 gene expression in lung cancer and reveals why the gene is expressed differently in small and non-small lung cancer cells.

Released: 7-Mar-2011 8:00 AM EST
Two Proteins Play Key Roles in Burkitt’s Lymphoma
Sbarro Health Research Organization (SHRO)

A new study from the Sbarro Health Research Organization Center for Biotechnology reveals new molecular insights into the understanding and treatment of Burkitt`s lymphoma, one of the most aggressive tumors affecting humans.

Released: 6-Jul-2011 7:00 PM EDT
Toxic Waste Dumps in Campania Region of Southern Italy Exact High Toll on Residents’ Health
Sbarro Health Research Organization (SHRO)

Scientific evidence is mounting in support of a significant increase in cancer mortality and malformations occurring in specific areas of the Campania Region of Southern Italy, where improper waste management and illegal waste trafficking have been repeatedly documented, according to “Wasting lives: the effects of toxic waste exposure on health. The case of Campania, Southern Italy” published in Cancer Biology & Therapy.

Released: 25-Jul-2011 4:00 PM EDT
New Avenues Open Up for Mesothelioma Targeted Therapy
Sbarro Health Research Organization (SHRO)

Researchers from the lab of Antonio Giordano, M.D., Ph.D., the Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine, have identified new potential anti-tumor agents that might be effective in treating mesothelioma, one of the deadliest cancer tumors.

Released: 28-Sep-2011 5:00 PM EDT
Tracking the 2009 H1N1 Influenza Virus in Campania, Italy
Sbarro Health Research Organization (SHRO)

An analysis of the high incidence of the H1N1 swine-origin influenza virus (S-OIV) in 2009 in the Campania region of Southern Italy presents important findings that provide a “significant pattern for emerging viral agents at risk in global health approaches to early diagnosis and prompt therapy,” according to an article in the Journal of Cellular Physiology.

Released: 15-Nov-2011 7:00 AM EST
New Adiponectin Compound Developed
Sbarro Health Research Organization (SHRO)

A compound that mimics the effects of adiponectin, a beneficial protein that is produced by fat tissue in healthy weight individuals and may exhibit protective effects against cancer, cardiovascular disease, inflammatory conditions and insulin resistance has been developed by an international consortium.

Released: 6-Dec-2011 12:05 PM EST
Novel Evidence Links Pretreatment Fasting Glucose to Slowed Cancer Progression
Sbarro Health Research Organization (SHRO)

Researchers from the Sbarro Institute for Cancer Research and Molecular Medicine and the Human Health Foundation report that in a multidisciplinary study of 420 non-diabetic, breast and metastatic colorectal cancer patients treated with targeted agents, lower levels of pretreatment fasting glucose were predictive of longer times to disease progression. Such evidence was particularly significant in breast cancer patients, according to results published in the Annals of Oncology.

Released: 17-Jan-2012 7:00 AM EST
Scriptaid Effects on Cancer Cell Lines
Sbarro Health Research Organization (SHRO)

Although endocrine therapy for breast cancer has shown excellent results in controlling the disease, responsiveness to the therapy depends on whether or not there is expression of estrogen receptors in breast cancer cells. Research from the Sbarro Institute for Cancer Research and Molecular Medicine, a nonprofit cancer, cardiovascular and diabetes research center located in Philadelphia, PA, reports on the effectiveness of a new molecule, Scriptaid that restores receptivity to endocrine therapy in breast cancer cell lines that had tested negative for the expression of estrogen receptors. The findings are reported in the Journal of Cellular Physiology.

Released: 28-Mar-2012 2:00 PM EDT
Novel Mechanism May Lead to New Targeted Pharmacological Cancer Treatment
Sbarro Health Research Organization (SHRO)

Inactivation of the retinoblastoma tumor suppressor protein (pRb) by phosphorylation triggers uncontrolled cell proliferation. Accordingly, activation of cyclin-dependent kinase (CDK)/cyclin complexes or downregulation of CDK inhibitors appears as a common event in human cancer. Now, a new study from the Sbarro Health Research Organization shows that Pin1 (protein interacting with NIMA (never in mitosis) A-), a peptidylprolyl isomerase involved in the control of protein phosphorylation, is an essential mediator for inactivation of the pRB.

Released: 29-Jun-2012 4:00 PM EDT
New Properties of Stem Cells via Simulated Microgravity
Sbarro Health Research Organization (SHRO)

A recent study led by Andrew Puca, Ph.D. under the supervision and direction of Antonio Giordano, M.D., Ph.D. set out to illustrate novel mechanical transduction properties of Hematopoietic Stem Cells in relation to defining the expression of humoral factors by facilitating paracrine/autocrine signalling via microgravity.

   
Released: 30-Nov-2012 3:50 PM EST
Numbers Count for What Concerns Cancer
Sbarro Health Research Organization (SHRO)

A new study on the incidence of breast cancer in Italy.

Released: 4-Apr-2013 12:40 PM EDT
Assessing Insulin Resistance Can Inform About Breast Cancer Risk
Sbarro Health Research Organization (SHRO)

The link between obesity and cancer seems now well established although the molecular mechanisms underlying this connection are still largely unexplored. A group of researchers in Italy led by Antonio Giordano, M.D., Ph.D., the Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine, and Center of Biotechnology, College of Science and Technology of the Temple University in Philadelphia, has studied the correlation between breast cancer and insulin resistance — an obesity-related condition in which certain cells fail to respond to the glucose-lowering action of the insulin hormone. Their findings appear in the Journal of Experimental and Clinical Cancer Research.

Released: 12-Apr-2013 7:00 AM EDT
The Dark-­‐Fighting Power of Cocoa Polyphenols Against NeurodegenerativeDiseases
Sbarro Health Research Organization (SHRO)

Epidemiological studies have indicated that dietary habits and antioxidants from diet can influence the incidence of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Released: 19-May-2013 1:00 PM EDT
Plea for a Correct Use of Stem Cells in Therapy
Sbarro Health Research Organization (SHRO)

The “Stem Cell Research Italy” Association (www.stemcellitaly.org) and the “Sbarro Health Research Organization” (www.shro.org) make a public plea for a correct use of stem cell therapy in Italy and Europe.

Released: 3-Jun-2013 11:00 AM EDT
Campania Teams Up Against Breast Cancer
Sbarro Health Research Organization (SHRO)

On 30 and 31 May it was held in the beautiful framework of Badia, Cava de 'Tirreni, at The Hotel Scapolatiello, the VII National Conference of ASME (Mediterranean Association of Senology) entitled "Breast cancer: state of the art". The event gathered together 130 breast cancer experts from various Italian regions who confronted on multiple themes of breast cancer research.

Released: 17-Jun-2013 2:00 PM EDT
Rome Calls for Doctor’s Care
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization congratulates Senator Ignazio R. Marino on his recent winning of the mayoral race for the Italian Capital, Rome.

Released: 2-Jul-2013 5:00 PM EDT
Can Virtual Reality Help Losing Weight?
Sbarro Health Research Organization (SHRO)

Can an avatar in a virtual environment contribute to weight loss in the real world? “Virtual reality is a powerful computer simulation of real situations in which the user interact as avatar and it can be used as support for a weight loss program” said Dr. Antonio Giordano and Dr. Giuseppe Russo of Sbarro Institute for Cancer Research and Molecular Medicine (Philadelphia, PA), in a study just published in Journal of Diabetes Science and Technology.

Released: 30-Jul-2013 8:25 AM EDT
Vitamin D and Breast Cancer Prevention: What’s the Current Evidence From Randomized Clinical Trials?
Sbarro Health Research Organization (SHRO)

In this study, the researchers focused on breast cancer, the most commonly diagnosed cancer and the second leading cause of cancer death in women from Western countries.

Released: 3-Sep-2013 4:00 AM EDT
Can the Zebrafish Help US to Search for New Pain Drugs?
Sbarro Health Research Organization (SHRO)

A new published study in Journal of Cellular Physiology by a team led by Dr. Antonio Giordano and Dr. Gianfranco Bellipanni of Sbarro Institute for Cancer Research and Molecular Medicine and Temple University (Philadelphia, USA) adds a new prospective on the research on pain perception.

Released: 16-Oct-2013 3:45 PM EDT
Cancer Mortality in the Metropolitan Area of Naples and Caserta Between 1988 and 2009: Lights and Shadows on Southern Italy
Sbarro Health Research Organization (SHRO)

A new study on cancer mortality in the metropolitan area of Naples and Caserta, Southern Italy, has been published in the scientific journal Cancer Biology &Therapy.

Released: 25-Oct-2013 12:00 PM EDT
SHRO Hosts "Conference on Current Advances in Medicine, Surgery and Biotechnology" on October 26 during National Italian American Foundation's Annual Gala Weekend in Washington, DC
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization, Inc. (SHRO), in collaboration with the National Italian American Foundation (NIAF), Temple University's College of Science and Technology and the Giovan Giacomo Giordano Foundation (http://www.shro.org/SHRO/IggGiordano.html) , will host the "Conference on Current Advances in Medicine, Surgery and Biotechnology" on October 26, 2013 at 3:00-5:00PM in the Independence Room of the Washington Hilton Hotel in Washington, DC.

Released: 18-Nov-2013 4:00 AM EST
An Upcoming Workshop to Explore the Endless Potential of Tissue Microarrays
Sbarro Health Research Organization (SHRO)

Philadelphia, 17.11.13: The Sbarro Health Research Organization, the College of Science and Technology of Temple University, Integrated Systems Engineering (ISENET) and ISENET-USA LLC teamed up to organize a Tissue Microarray (TMA) Workshop on the value of the TMA technology in biomarker validation, drug response and diagnostics on November 20th, 2013, at University City Science Center, 3711 Market Street, Philadelphia PA.

Released: 17-Jan-2014 9:05 AM EST
Searching for the Magic Bullet Against Cancer Caused by Asbestos: One Step Closer?
Sbarro Health Research Organization (SHRO)

Mesothelioma is a very aggressive cancer associated with asbestos exposure, which is usually diagnosed in an advanced stage. So far no therapeutic strategy has proven effective against this deadly cancer and the prognosis remains very poor with only few exceptions.

Released: 19-Mar-2014 5:00 AM EDT
Alzheimer’s Disease Progression and Its Physiological Aging: A New Therapeutic Scenario?
Sbarro Health Research Organization (SHRO)

a new study from the Sbarro Health Research Organization and the University of L’Aquila (Italy) has investigated the role of 4-HNE and PPAR β/δ during AD progression and in physiological aging.

Released: 28-Jul-2014 8:00 AM EDT
The Guardian of Genome and Targeted Therapies in Non Diabetic, HER2 Positive Breast Cancer Patients: Adding New Dowels to a Dated Puzzle
Sbarro Health Research Organization (SHRO)

Research in breast cancer has lately allowed to characterize molecular features that have increasingly become the targets for novel therapeutic interventions. Trastuzumab has revolutionized the treatment of patients with HER2 positive breast cancer. At the same time, we have gained knowledge on the importance of glucose metabolism in several tumours, including breast cancer

Released: 20-Oct-2014 8:00 AM EDT
National Italian American Foundation's Annual Gala Weekend in Washington DC Hosts the Medical Conference of the Sbarro Health Research Organization
Sbarro Health Research Organization (SHRO)

he Sbarro Health Research Organization, Inc. (SHRO), in collaboration with the National Italian American Foundation (NIAF), Temple University's College of Science and Technology and the Giovan Giacomo Giordano Foundation, will organize the medical conference "Bioinnovation: towards new treatment of disease in Biopharma and Academia" that will be held in the Jay Room of the Washington Hilton Hotel in Washington, DC. on October 25th 2014 from 2:00 to 4:00PM .

Released: 6-Nov-2014 12:00 PM EST
Diffuse Gastric Cancer: A Key Tumor Suppressor Is Set Off the Nuclear Stage
Sbarro Health Research Organization (SHRO)

A new molecular alteration, consisting in the subcellular delocalization of the well known tumor suppressor protein pRb2/p130, has been recently identified, adding up a new component in the complex molecular portrait that characterizes gastric cancer.

Released: 13-Jan-2015 5:00 AM EST
Breast Cancer: Anthropometric and Metabolic Dowels Integrate Metabolic Details and Contribute to an Increasingly Complex Puzzle
Sbarro Health Research Organization (SHRO)

Once more, the multifactorial and heterogeneous nature of breast cancer fascinate researchers and is newly confirmed by the results of a study entitled “Anthropometric, metabolic and molecular determinants of human epidermal growth factor receptor 2 expression in luminal b breast cancer”, published in December 2014 in the international journal Journal of Cell Physiology.


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