In 1993, Antonio Giordano, M.D., Ph.D., founded the Sbarro Institute with a generous donation from Mario Sbarro, the Founder of the Sbarro restaurant chain, following Dr. Giordano’s discovery of the tumor suppressor gene pRb2. Initially named the Sbarro Institute, the research center was located at Thomas Jefferson University, where Dr. Giordano was a professor.

When Dr. Giordano moved to Temple University in 2002, he and twenty fellow scientists forged a new, three-year alliance with Temple University in Philadelphia, Pennsylvania. Under the new arrangement, the original Sbarro Institute was renamed the Sbarro Health Research Organization, Inc. (SHRO), which includes the Sbarro Institute for Cancer Research and Molecular Medicine at Temple and the SHRO-affiliated laboratory at the University of Siena in Siena, Italy.

Under a 2005 agreement, the Sbarro Institute for Cancer Research and Molecular Medicine received continued funding from Temple and expanded its program to include work on the relationship between obesity and cancer and instituted a new program on molecular therapeutics to explore how molecular genetic research can be applied to patient therapies and diagnostics.

SHRO relies on grants and private donations to fund important biomedical research.

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Cited By

Year

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ...
Autophagy 8 (4), 445-544, 2012

6004

2012

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

A Koff, A Giordano, D Desai, K Yamashita, JW Harper, S Elledge, ...
Science 257 (5077), 1689-1694, 1992

1211

1992

RB and cell cycle progression

C Giacinti, A Giordano
Oncogene 25 (38), 5220, 2006

940

2006

Cell cycle kinases as therapeutic targets for cancer

S Lapenna, A Giordano
Nature reviews Drug discovery 8 (7), 547, 2009

869

2009

Recruitment of p300/CBP in p53-dependent signal pathways

ML Avantaggiati, V Ogryzko, K Gardner, A Giordano, AS Levine, K Kelly
Cell 89 (7), 1175-1184, 1997

820

1997

From the laboratory bench to the patient's bedside an update on clinical trials with mesenchymal stem cells

A Giordano, U Galderisi, IR Marino
Journal of cellular physiology 211 (1), 27-35, 2007

734

2007

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer

V Esposito, A Baldi, A De Luca, AM Groger, M Loda, GG Giordano, ...
Cancer Research 57 (16), 3381-3385, 1997

563

1997

Cyclins, cyclin-dependent kinases and cdk inhibitors implications in cell cycle control and cancer

TK MacLachlan, N Sang, A Giordano
Critical Reviews™ in Eukaryotic Gene Expression 5 (2), 1995

385

1995

Cell cycle and apoptosis

B Pucci, M Kasten, A Giordano
Neoplasia (New York, NY) 2 (4), 291, 2000

383

2000

Human p300 protein is a coactivator for the transcription factor MyoD

W Yuan, G Condorelli, M Caruso, A Felsani, A Giordano
Journal of Biological Chemistry 271 (15), 9009-9013, 1996

343

1996

p300 and CBP partners for life and death

A Giordano, ML Avantaggiati
Journal of cellular physiology 181 (2), 218-230, 1999

338

1999

Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer

N Normanno, M Di Maio, E De Maio, A De Luca, A De Matteis, A Giordano, ...
Endocrine-related cancer 12 (4), 721-747, 2005

331

2005

Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

X Mayol, X Grana, A Baldi, N Sang, Q Hu, A Giordano
Oncogene 8 (9), 2561-2566, 1993

309

1993

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

A Giordano, P Whyte, E Harlow, BR Franza Jr, D Beach, G Draetta
Cell 58 (5), 981-990, 1989

302

1989

Simian virus-40 large-T antigen binds p53 in human mesotheliomas

M Carbone, P Rizzo, PM Grimley, A Procopio, DJY Mew, V Shridhar, ...
Nature medicine 3 (8), 908, 1997

301

1997

Detection and characterization of CD133+ cancer stem cells in human solid tumours

V Tirino, V Desiderio, R d'Aquino, F De Francesco, G Pirozzi, U Galderisi, ...
PloS one 3 (10), e3469, 2008

294

2008

p300 is required for MyoD‐dependent cell cycle arrest and muscle‐specific gene transcription

PL Puri, ML Avantaggiati, C Balsano, N Sang, A Graessmann, A Giordano, ...
The EMBO journal 16 (2), 369-383, 1997

292

1997

Formation of p27-CDK complexes during the human mitotic cell cycle.

TJ Soos, H Kiyokawa, JS Yan, MS Rubin, A Giordano, A DeBlasio, ...
Cell growth & differentiation: the molecular biology journal of the American …, 1996

277

1996

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107

PP Claudio, CM Howard, A Baldi, A De Luca, Y Fu, G Condorelli, Y Sun, ...
Cancer research 54 (21), 5556-5560, 1994

265

1994

Cell cycle regulation and neural differentiation

U Galderisi, FP Jori, A Giordano
Oncogene 22 (33), 5208, 2003

262

2003

€4 Million Grant to Improve Mental Health and Wellbeing of Health Professionals and Patient Safety

The largest initiative to improve hospital work environments to date has officially begun, with an award of 4 million Euros from the European Union’s Horizon 2020 program. The grant will support the international partnership of some of the world’s leading Universities led by KU Leuven and the University of Pennsylvania School of Nursing’s Center for Health Outcomes and Policy Research.
10-Dec-2019 11:45:08 AM EST

Medicine, Media & Patients: A New Professional Language

Panel to Convene at Annual Medical conference at NIAF
31-Oct-2019 08:55:28 AM EDT

New Natural Therapeutic Agent to Fight Diabetic Nephropathy

The extract successfully restored the blood glucose levels, body weight, and normalized oxidative stress on renal function in a test group of Zucker diabetic fatty rats.
14-Jun-2019 11:05:33 AM EDT

Exploiting RB1 Predictive Value for Cancer Therapy in the Clinical Setting: Lost in Translation

RB1 status has emerged not only as a key factor in cancer development and progression, but also as a crucial determinant of cell fate in response to various anticancer treatments
11-Jun-2019 04:10:02 PM EDT

Cervical Cancer During Pregnancy, Though Serious, is Highly Treatable According to New Research Review

“Individualized therapies are strongly recommended and the treatment decision should be made collaboratively with a multidisciplinary team consisting of obstetricians, gynecologists, oncologists, pediatricians, and psychologists,” says researcher.
04-Jun-2019 09:55:03 AM EDT

Brain Cancer Drug Reactivates Body's Natural Defenses

Drug reactivates p53 tumor suppressor protein and increases chemotherapy effectiveness in potential glioblastoma breakthrough.
20-May-2019 04:05:57 AM EDT

Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute

Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” describes how inhibition of TDG, known for its role in cell repair and proliferation, may be used to trigger cell death of cancerous melanoma cells and halt tumor growth.
10-Apr-2019 12:05:49 PM EDT

Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute

Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” describes how inhibition of TDG, known for its role in cell repair and proliferation, may be used to trigger cell death of cancerous melanoma cells and halt tumor growth.
10-Apr-2019 12:05:49 PM EDT

Decoy Damaged DNA Discovers New Gene Repair Protein

A synthetic DNA structure was used as bait to capture nuclear proteins, revealing previously unknown role of HNRNPD in the cellular response to DNA damage.
14-Mar-2019 09:00:36 AM EDT

Repurposed Parasite Drug New Weapon Against Mesothelioma

Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.
06-Mar-2018 08:55:33 AM EST

Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery

A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.
01-Mar-2018 09:00:45 AM EST

Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery

A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.
01-Mar-2018 09:00:45 AM EST

Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery

A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.
01-Mar-2018 09:00:45 AM EST

Fluctuations of Sex Steroid Hormone Could be Culprit in Age-Related Macular Degeneration

Gender-based differences may influence several ocular conditions, suggesting that fluctuations in sex steroid homeostasis may have direct effects on eye physiology and the pathogenesis of conditions like Age-Related Macular Degeneration (AMD).
17-Jan-2018 04:05:20 PM EST

Fluctuations of Sex Steroid Hormone Could be Culprit in Age-Related Macular Degeneration

Gender-based differences may influence several ocular conditions, suggesting that fluctuations in sex steroid homeostasis may have direct effects on eye physiology and the pathogenesis of conditions like Age-Related Macular Degeneration (AMD).
17-Jan-2018 04:05:20 PM EST

Detecting Pompe Disease with More Accuracy Key to Urgent Intervention

Researchers identified a new, more sensitive screening test to recognize Pompe disease, a metabolic disorder affecting cellular processing of glycogen in numerous tissues of the body.
02-Jan-2018 09:00:11 AM EST

Xylella: a conscience, not a science problem

The Sbarro Health Research Organization congratulates the Italian researchers who were able to prove a direct causal link between the infection by Xylella fastidiosa and the death of olive trees in southern Italy.
21-Dec-2017 02:30:05 PM EST

From Medical Discovery to Food and Fine Arts, Italian-American Contributions Celebrated at Annual Foundation Conference

At this year’s 42nd annual NIAF Gala Weekend at the Washington Marriott Wardman Park Hotel in D.C., all aspects of Italian heritage were celebrated, including food, the fine arts, and scientific discovery. The weekend’s events included the medical conference, “Mediterranean Diet, Human Health and Longevity,” sharing the latest in research into a vital part of Italian culture –– diet and food. Conference presentations explored how the recipes of Italian grandmothers are among the healthiest in the world and can even help fight disease, such as cancer.
04-Dec-2017 08:55:55 AM EST

From Medical Discovery to Food and Fine Arts, Italian-American Contributions Celebrated at Annual Foundation Conference

At this year’s 42nd annual NIAF Gala Weekend at the Washington Marriott Wardman Park Hotel in D.C., all aspects of Italian heritage were celebrated, including food, the fine arts, and scientific discovery. The weekend’s events included the medical conference, “Mediterranean Diet, Human Health and Longevity,” sharing the latest in research into a vital part of Italian culture –– diet and food. Conference presentations explored how the recipes of Italian grandmothers are among the healthiest in the world and can even help fight disease, such as cancer.
04-Dec-2017 08:55:55 AM EST

New Cancer Therapies Earn Sbarro Health Research Organization President Antonio Giordano 2017 CORE Prize for Oncology

The CORE Prize for Oncology 2017 was awarded to Professor Antonio Giordano for his groundbreaking discoveries in the field of the cell cycle, which have established an understanding of the fundamental mechanisms at the basis of cancer and the development of a new class of anticancer therapeutics.
27-Nov-2017 09:00:49 AM EST

Italian-American Researchers Present Mediterranean Diet, Health, and Longevity at Annual Medical Conference

Sbarro Health Research Organization President Antonio Giordano introduces program at National Italian American Foundation 42nd Anniversary Gala Weekend In Washington D.C.
31-Oct-2017 04:05:27 PM EDT

Research Reveals Gene Differences in Mouse Model Versus Humans

Aspects of gene function in humans can be predicted by studies of the corresponding gene in mice, but new research findings have revealed important divergences between the species which scientists will need to understand better through further investigation.
05-Sep-2017 09:00:18 AM EDT

Adding Radiation Treatments to Inoperable Lung Cancer Increases Survival by up to One Year

Patients with unresectable, or inoperable, lung cancer are often given a dismal prognosis, with low rates of survival beyond a few years. Researchers exploring combination therapies have recently discovered improved survival rates by up to one year when patients treated with a newly formulated chemotherapy regimen are also given radiation therapy.
25-Aug-2017 11:05:22 AM EDT

Targeting Cell Cycle Reactivation Caused by Inflammation May Provide the Way to Prevent Neuron Death in Alzheimer’s Disease

Researchers have discovered a clue to the mechanism for neuronal degeneration and possible target for a therapeutic approach to these disorders.
23-Aug-2017 04:55:31 PM EDT

Does Radiology Contrast Medium Matter? To Fragile Cancer Patients, Yes

Given the choice of contrast medium for a computed tomography (CT) scan, most patients wouldn’t know the difference between the two iodine-based options commonly used in cancer cases. But for some patients, particularly in the already fragile and potentially compromised cancer patient, it is important to be aware that iodated contrast media has been linked to kidney impairment and a condition known as Contrast-induced nephropathy (CIN).
07-Aug-2017 11:05:35 AM EDT

Clinical Data Confirms Efficacy of Pre-Surgery Chemo in Triple-Negative Breast Cancer

Researchers analyzed data confirming the improved outcomes in both short- and long-term survival in patients that underwent neoadjuvant chemotherapy prior to surgery for triple-negative breast cancer. The study included 213 patients at 8 Italian cancer centres whose diagnoses were characterized by clinical, molecular, and therapeutic features of triple-negative breast cancer, an aggressive form of cancer with limited treatment options.
25-Jul-2017 11:05:41 AM EDT

Tomato Extract Fights Stomach Cancer, Ripe for Further Study

A new study suggests that the use of tomato — a key food of the Mediterranean diet — should be explored to develop supportive strategies against gastric cancer
13-May-2017 12:05:03 AM EDT

Tomato Extract Fights Stomach Cancer, Ripe for Further Study

A new study suggests that the use of tomato — a key food of the Mediterranean diet — should be explored to develop supportive strategies against gastric cancer
13-May-2017 12:05:03 AM EDT

Tomato Extract Fights Stomach Cancer, Ripe for Further Study

A new study suggests that the use of tomato — a key food of the Mediterranean diet — should be explored to develop supportive strategies against gastric cancer
13-May-2017 12:05:03 AM EDT

Thorough Genotyping and Repurposed Drugs Key to Treating Small-Cell Lung Cancer, says Cancer Expert

Cancer expert Antonio Giordano, MD, PhD, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, describes the recent progress and future possibilities of treating SCLC.
13-Apr-2017 07:05:04 AM EDT

Thorough Genotyping and Repurposed Drugs Key to Treating Small-Cell Lung Cancer, says Cancer Expert

Cancer expert Antonio Giordano, MD, PhD, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, describes the recent progress and future possibilities of treating SCLC.
13-Apr-2017 07:05:04 AM EDT

Sbarro Health Research Organization President Re-Elected to Board of Italian American Foundation

Giordano is joined on the board by Corporation for Public Broadcasting President and CEO Patricia de Stacy Harrison and former Talk America President, Chairman and CEO Gabriel A. Battista who will serve as co-chairperson of the Foundation
29-Mar-2017 02:05:08 PM EDT

Sbarro Health Research Organization President Re-Elected to Board of Italian American Foundation

Giordano is joined on the board by Corporation for Public Broadcasting President and CEO Patricia de Stacy Harrison and former Talk America President, Chairman and CEO Gabriel A. Battista who will serve as co-chairperson of the Foundation
29-Mar-2017 02:05:08 PM EDT

Economic Disparities a Growing Concern for Cancer Diagnosis and Treatment

The most recent global cancer data from the WHO highlights the growing differences in mortality rate among regions of the world bearing very different economic circumstances.
07-Mar-2017 01:00:25 PM EST

Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.
08-Feb-2017 10:30:35 AM EST

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Email Address: : president@shro.org

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