The lab of Evan Snyder, M.D. Ph.D. at Sanford Burnham Prebys Medical Discovery Institute, is at the forefront of stem cell research,  investigating how neural stem cells can be used to treat diseases like Parkinson’s disease & Bipolar disorder.

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Scientists identify promising immunotherapy combination for pediatric brain cancer

Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy.
15-May-2020 12:50:48 PM EDT

Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.
11-May-2020 12:45:00 PM EDT

Underlying Molecular Mechanism of Bipolar Disorder Revealed

An international collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP), with major participation from Yokohama School of Medicine, Harvard Medical School, and UC San Diego, has identified the molecular mechanism behind lithium’s effectiveness in treating bipolar disorder patients. The study, published in Proceedings of the National Academy of Sciences (PNAS), utilized human induced pluripotent stem cells (hiPS cells) to map lithium’s response pathway, enabling the larger pathogenesis of bipolar disorder to be identified.
05-May-2017 04:05:43 PM EDT

New Form of Stem Cell Communication Rescues Diseased Neurons

Investigators at Sanford-Burnham Medical Research Institute, the Karolinska Institutet, Beth Israel Deaconess Medical Center, Harvard Medical School and Université Libre de Bruxelles have demonstrated in mouse models that transplanted stems cells, when in direct contact with diseased neurons, send signals through specialized channels that rescue the neurons from death.
01-Feb-2010 03:15:06 PM EST

Scientists Develop Method for Comprehensive Proteome Analysis

Investigators at Burnham Institute for Medical Research have deciphered a large percentage of the total protein complement (proteome) in Schizosaccharomyces pombe (S. pombe) fission yeast.
08-Apr-2009 01:45:16 PM EDT

Burnham and HeadNorth Foundation Join Forces to Advance Spinal Cord Research

HeadNorth Foundation has pledged $975,000 to Burnham Institute for Medical Research to support cutting-edge stem cell research.
03-Dec-2008 11:50:25 AM EST

CIRM Awards $3.79 Million to Burnham Institute

The California Institute for Regenerative Medicine (CIRM) announced today the award of $3.79 million to the Burnham Institute for Medical Research (Burnham) for development of a collaborative shared laboratory and expansion of the Institute's training courses in stem cell research. Burnham was one of 17 institutions receiving grants from CIRM for a total of more than $50 million.
06-Jun-2007 08:35:37 AM EDT

Stem Cells Act to Benefit Mice with Neurodegenerative Disease

Human embryonic stem cells (hESCs) can treat degenerative diseases safely and effectively, and do so by invoking multiple mechanisms. These were a few of a number of conclusions arrived at by an international collaboration led by Evan Y. Snyder, M.D., Ph.D., to be published in Nature Medicine.
09-Mar-2007 09:05:47 AM EST

CIRM Awards $5.9 Million to Burnham Institute

Burnham Institute for Medical Research will receive $ 5,925,878 in grants awarded from the California Institute for Regenerative Medicine as part of the first research grants approved under Proposition 71. The Independent Citizen's Oversight Committee approved the allocation of $45 million to fund 72 grants awarded under CIRM's Scientific Excellence through Exploration and Development Grant Program.
18-Feb-2007 12:40:57 PM EST

Burnham Institute Selected for Exploratory Center for Stem Cell Research

The Burnham Institute will receive $3 M over the next three years from the NIH to develop an "Exploratory Center for Human Embryonic Stem Cell Research". The grant provides funds to support research that will advance understanding of the fundamental biology of human embryonic stem cells.
10-Aug-2005 08:30:06 AM EDT

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