Antonio Giordano, MD, PhD, is an oncologist and geneticist, as well as founder and president of the Sbarro Health Research Organization and director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia, Pennsylvania. He works on molecular therapeutics and also studies the connections between obesity and cancer.

Antonio Giordano grew up in Naples, Italy, where his father, Giovan Giacomo Giordano, was an oncologist and pathologist at the National Cancer Institute of Naples and a professor at the University of Naples. Giordano decided to branch out and start a career in research that was more oriented towards genetics applied to pathology. Early on, while following his father's research, he became interested in the link between the effect of toxic waste on the environment and the increasing cancer rates in the Campania region in Italy.

Giordano earned his medical degree at the University of Naples in 1986, and his doctorate at the University of Trieste in 1990.  He has published over 600 papers on gene therapy, cell cycle, genetics of cancer, and epidemiology. His early research includes seminal work done in 1989, demonstrating the importance of cell cycle proteins in the functioning of DNA tumor viruses. The transforming gene products of these viruses, such as the E1A oncoproteins of adenovirus 5, led to the identification of cellular factor p60, known as cyclin A. This research was the first demonstration of a physical link between cellular transformation and the cell cycle, thereby paving the way for the melding of these two areas of research. It also helped to open a very exciting avenue of research involving investigators with expertise in different aspects of growth control and cancer.Giordano’s lab also discovered the tumor suppressor gene RB2/p130 and the cell cycle kinases CDK9 and CDK10, two other key players in cell cycle regulation and cell differentiation.

Antonio Giordano is the recipient of the Irving J. Selikoff Award for Cancer Research, the Rotary International Award, and Lions Club Napoli-Europa. He has also received the title of Knight of the Republic and Commander of the Order of Merit of the Italian Republic. At the 25th anniversary of the National Organization of Italian American Women, he was awarded the Cross of Merit Melitense, an honor of the Sovereign Military Order of Malta.

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Cited By


Guidelines for the use and interpretation of assays for monitoring autophagy



Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle



RB and cell cycle progression



Cell cycle kinases as therapeutic targets for cancer



Recruitment of p300/CBP in p53-dependent signal pathways



From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells



The adipose organ



Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer



Cell cycle and apoptosis



Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer



p300 and CBP: partners for life and death



Human p300 protein is a coactivator for the transcription factor MyoD



Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer



Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.



A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells



Detection and characterization of CD133+ cancer stem cells in human solid tumours



Simian virus-40 large-T antigen binds p53 in human mesotheliomas



p300 is required for MyoD‐dependent cell cycle arrest and muscle‐specific gene transcription



Formation of p27-CDK complexes during the human mitotic cell cycle.



Cell cycle regulation and neural differentiation



New Mesothelioma Drugs, Once Hailed as Gamechangers, Don’t Live Up to the Hype

Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mostly related to asbestos exposure whose incidence is constantly rising, especially in low-income countries.
10-Mar-2022 06:05:08 AM EST

Researchers Explore Potential Biomarker for Rare Gynecological Cancers in Long Non-Coding RNAs

Long Non-Codign RNAs (lncRNAs) are detectable in body fluids, such as the blood, saliva, and urine, and are therefore emerging as a novel method for cancer diagnosis, but few studies have explored the link between lncRNAs and choriocarcinoma (CC), a rare but serious type of cancer affecting the female reproductive organs.
24-Jun-2021 10:40:01 AM EDT

SHRO’s Giordano Meets with Speaker Pelosi at Italian Embassy in Washington

At the prestigious setting of Villa Firenze, the Italian Embassy in Washington, DC, on the occasion of a farewell party for outgoing Ambassador Armando Varricchio, Professor Antonio Giordano was in attendance among the many high-ranking government officials and honored guests.
20-May-2021 04:30:49 PM EDT

Cancer Experts Call for Reform of Clinical Trials, with an Emphasis on Independent Studies

A recently published paper addresses the threat posed by overstating the significance of inconclusive studies to the public by both the media and the scientific community itself.
22-Mar-2021 03:35:55 PM EDT

International Research Collaboration to Address Delayed Diagnosis of Rare Gynecological Cancers

Sbarro Health Research Organization (SHRO) Founder and Director, Antonio Giordano, M.D., Ph.D., has recently published a landmark paper in collaboration with another 28 co-authors hailing from 14 different countries, as part of the GYNOCARE COST Action (CA18117).
19-Feb-2021 09:00:29 AM EST

Getting Basic Research from the Lab to Independent Clinical Trials, Especially in Rare Cancers Like Mesothelioma

On the 18th and 19th of February, Sbarro Health Research Organization (SHRO) Founder and Director, Antonio Giordano, M.D., Ph.D., will host an online medical conference titled, “Why do we need independent research in oncology?”
11-Feb-2021 08:35:56 AM EST

SHRO Founder Leads Search for Fauci Fellows

The National Italian American Foundation (NIAF) is now accepting applications for the inaugural class of Fauci Fellowships, created in recognition of Dr. Anthony S. Fauci’s contributions to humanity and the medical and scientific community.
10-Feb-2021 10:25:56 AM EST

Hijacking cancer cells with a virus while blocking cells’ antiviral defenses could knock out mesothelioma

A study exploring a new combination of therapeutic agents has recently been published in the International Journal of Molecular Sciences, describing dl922-947, an oncolytic adenovirus, and AZD1775, an inhibitor of the DNA damage checkpoint kinase WEE1, and their possible efficacy to treat MPM.
06-Oct-2020 09:00:38 AM EDT

Understanding Neurodegenerative Disease Such as Alzheimer’s and ALS by Examining the Overlap of microRNAs, Oxidative Stress, and Mitochondria Dysfunction

These aspects may have important implications for the design of new drugs and therapeutic interventions for these progressive and incurable diseases.
26-Aug-2020 02:10:53 PM EDT

Key Immune System Genes Identified to Explain High COVID Deaths and Spread in Northern Italy Versus Fewer Cases and Deaths in the South

Not long after the Coronavirus disease (Covid-19) outbreak in China, Italy was hard-hit by the infection and rapidly became one of the countries with the highest mortality rate.
23-Jul-2020 08:05:41 AM EDT

Despite Promising Lab Results, Most Precision Medicine Therapies for Mesothelioma Fail in the Clinical Setting

Malignant mesothelioma (MM) is a lethal cancer mainly caused by exposure to asbestos, for which, unfortunately, no current treatment has proven effective, despite the identification of several promising therapeutic targets over the years.
20-Jul-2020 11:25:37 AM EDT

Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness

An international team of investigators has recently discovered that the receptor tyrosine-kinase EphA2 activated by the growth factor progranulin is a tumorigenic driver of bladder cancer progression.
08-Jun-2020 02:05:55 PM EDT

Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response

Researchers predict the Human Leukocyte Antigen (HLA) gene has a key role in shaping immune response to COVID.
29-May-2020 02:40:57 PM EDT

Researchers Silence PRMT5 Gene to Slow Mesothelioma Using Precision Medicine

Silencing of the protein coding gene PRMT5 has possible therapeutic potential for treating Mesothelioma (MM), according to a recent in vitro study published in the Journal of Cellular and Molecular Medicine.
01-May-2020 11:50:22 AM EDT

Considerations about current evolution of SARS-nCOV-2 epidemic in Italy

In Italy, a COVID-19 epidemic is raging. This analysis, which might be useful also to forecast the next epidemic trends in the U.S., is briefly recapitulated in the following document.
12-Mar-2020 10:15:45 AM EDT

Understanding COVID-19 Origins First Step to Treating Cases, Stopping Spread

“The new virus originating from Wuhan is the third coronavirus that has made the ‘jump’ from animals to humans,” explains Enrico Bucci, Ph.D., professor and research scientist at the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia.
09-Mar-2020 08:55:10 AM EDT

Turmeric and the Anti-Cancer Properties of Curcumin Discussed in Research Review

The review has collected studies concerning the anticancer potential of curcumin against the most widespread cancers and also describing the molecular mechanisms of action.
30-Dec-2019 04:35:01 PM EST

Medicine, Media & Patients: A New Professional Language

Panel to Convene at Annual Medical conference at NIAF
31-Oct-2019 08:55:28 AM EDT

New Natural Therapeutic Agent to Fight Diabetic Nephropathy

The extract successfully restored the blood glucose levels, body weight, and normalized oxidative stress on renal function in a test group of Zucker diabetic fatty rats.
14-Jun-2019 11:05:33 AM EDT

Exploiting RB1 Predictive Value for Cancer Therapy in the Clinical Setting: Lost in Translation

RB1 status has emerged not only as a key factor in cancer development and progression, but also as a crucial determinant of cell fate in response to various anticancer treatments
11-Jun-2019 04:10:02 PM EDT

Cervical Cancer During Pregnancy, Though Serious, is Highly Treatable According to New Research Review

“Individualized therapies are strongly recommended and the treatment decision should be made collaboratively with a multidisciplinary team consisting of obstetricians, gynecologists, oncologists, pediatricians, and psychologists,” says researcher.
04-Jun-2019 09:55:03 AM EDT

Brain Cancer Drug Reactivates Body's Natural Defenses

Drug reactivates p53 tumor suppressor protein and increases chemotherapy effectiveness in potential glioblastoma breakthrough.
20-May-2019 04:05:57 AM EDT

Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute

Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” describes how inhibition of TDG, known for its role in cell repair and proliferation, may be used to trigger cell death of cancerous melanoma cells and halt tumor growth.
10-Apr-2019 12:05:49 PM EDT

Decoy Damaged DNA Discovers New Gene Repair Protein

A synthetic DNA structure was used as bait to capture nuclear proteins, revealing previously unknown role of HNRNPD in the cellular response to DNA damage.
14-Mar-2019 09:00:36 AM EDT

Repurposed Parasite Drug New Weapon Against Mesothelioma

Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.
06-Mar-2018 08:55:33 AM EST

Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery

A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.
01-Mar-2018 09:00:45 AM EST

Fluctuations of Sex Steroid Hormone Could be Culprit in Age-Related Macular Degeneration

Gender-based differences may influence several ocular conditions, suggesting that fluctuations in sex steroid homeostasis may have direct effects on eye physiology and the pathogenesis of conditions like Age-Related Macular Degeneration (AMD).
17-Jan-2018 04:05:20 PM EST

Detecting Pompe Disease with More Accuracy Key to Urgent Intervention

Researchers identified a new, more sensitive screening test to recognize Pompe disease, a metabolic disorder affecting cellular processing of glycogen in numerous tissues of the body.
02-Jan-2018 09:00:11 AM EST

Xylella: A Conscience, Not a Science Problem

The Sbarro Health Research Organization congratulates the Italian researchers who were able to prove a direct causal link between the infection by Xylella fastidiosa and the death of olive trees in southern Italy.
21-Dec-2017 02:30:05 PM EST

From Medical Discovery to Food and Fine Arts, Italian-American Contributions Celebrated at Annual Foundation Conference

At this year’s 42nd annual NIAF Gala Weekend at the Washington Marriott Wardman Park Hotel in D.C., all aspects of Italian heritage were celebrated, including food, the fine arts, and scientific discovery. The weekend’s events included the medical conference, “Mediterranean Diet, Human Health and Longevity,” sharing the latest in research into a vital part of Italian culture –– diet and food. Conference presentations explored how the recipes of Italian grandmothers are among the healthiest in the world and can even help fight disease, such as cancer.
04-Dec-2017 08:55:55 AM EST

New Cancer Therapies Earn Sbarro Health Research Organization President Antonio Giordano 2017 CORE Prize for Oncology

The CORE Prize for Oncology 2017 was awarded to Professor Antonio Giordano for his groundbreaking discoveries in the field of the cell cycle, which have established an understanding of the fundamental mechanisms at the basis of cancer and the development of a new class of anticancer therapeutics.
27-Nov-2017 09:00:49 AM EST

Italian-American Researchers Present Mediterranean Diet, Health, and Longevity at Annual Medical Conference

Sbarro Health Research Organization President Antonio Giordano introduces program at National Italian American Foundation 42nd Anniversary Gala Weekend In Washington D.C.
31-Oct-2017 04:05:27 PM EDT

Research Reveals Gene Differences in Mouse Model Versus Humans

Aspects of gene function in humans can be predicted by studies of the corresponding gene in mice, but new research findings have revealed important divergences between the species which scientists will need to understand better through further investigation.
05-Sep-2017 09:00:18 AM EDT

Adding Radiation Treatments to Inoperable Lung Cancer Increases Survival by up to One Year

Patients with unresectable, or inoperable, lung cancer are often given a dismal prognosis, with low rates of survival beyond a few years. Researchers exploring combination therapies have recently discovered improved survival rates by up to one year when patients treated with a newly formulated chemotherapy regimen are also given radiation therapy.
25-Aug-2017 11:05:22 AM EDT

Targeting Cell Cycle Reactivation Caused by Inflammation May Provide the Way to Prevent Neuron Death in Alzheimer’s Disease

Researchers have discovered a clue to the mechanism for neuronal degeneration and possible target for a therapeutic approach to these disorders.
23-Aug-2017 04:55:31 PM EDT

Does Radiology Contrast Medium Matter? To Fragile Cancer Patients, Yes

Given the choice of contrast medium for a computed tomography (CT) scan, most patients wouldn’t know the difference between the two iodine-based options commonly used in cancer cases. But for some patients, particularly in the already fragile and potentially compromised cancer patient, it is important to be aware that iodated contrast media has been linked to kidney impairment and a condition known as Contrast-induced nephropathy (CIN).
07-Aug-2017 11:05:35 AM EDT

Clinical Data Confirms Efficacy of Pre-Surgery Chemo in Triple-Negative Breast Cancer

Researchers analyzed data confirming the improved outcomes in both short- and long-term survival in patients that underwent neoadjuvant chemotherapy prior to surgery for triple-negative breast cancer. The study included 213 patients at 8 Italian cancer centres whose diagnoses were characterized by clinical, molecular, and therapeutic features of triple-negative breast cancer, an aggressive form of cancer with limited treatment options.
25-Jul-2017 11:05:41 AM EDT

Tomato Extract Fights Stomach Cancer, Ripe for Further Study

A new study suggests that the use of tomato — a key food of the Mediterranean diet — should be explored to develop supportive strategies against gastric cancer
13-May-2017 12:05:03 AM EDT

Thorough Genotyping and Repurposed Drugs Key to Treating Small-Cell Lung Cancer, says Cancer Expert

Cancer expert Antonio Giordano, MD, PhD, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, describes the recent progress and future possibilities of treating SCLC.
13-Apr-2017 07:05:04 AM EDT

Sbarro Health Research Organization President Re-Elected to Board of Italian American Foundation

Giordano is joined on the board by Corporation for Public Broadcasting President and CEO Patricia de Stacy Harrison and former Talk America President, Chairman and CEO Gabriel A. Battista who will serve as co-chairperson of the Foundation
29-Mar-2017 02:05:08 PM EDT

Economic Disparities a Growing Concern for Cancer Diagnosis and Treatment

The most recent global cancer data from the WHO highlights the growing differences in mortality rate among regions of the world bearing very different economic circumstances.
07-Mar-2017 01:00:25 PM EST

Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.
08-Feb-2017 10:30:35 AM EST

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