Sreemathi  Logan, PhD

Sreemathi Logan, PhD

University of Oklahoma, College of Medicine

Assistant Professor, Department of Biochemistry and Physiology

Expertise: GeroscienceAgingCell Biology

Sreemathi Logan, Ph.D., is a faculty member in the Department of Biochemistry and Physiology at the University of Oklahoma College of Medicine and a researcher in the Oklahoma Center for Geroscience and Healthy Brain Aging. At the Center for Geroscience, she also directs the Animal Model Development and Behavioral Analysis (AMD-BA) core as part of the Center of Biomedical Research Excellence (CoBRE) grant. Her career in research has encompassed many aspects of aging, including her early work on Alzheimer’s disease in the initial characterization of the 5x FAD model generated by Dr. Robert Vassar at Northwestern University Chicago. The current focus of her research lab is to pursue mechanisms underlying cognitive dysfunction associated with age and neurodegenerative disorders. More specifically, she is interested in the role of astrocyte mitochondrial metabolism and redox status that alter the astrocytic phenotype and increase gliosis during aging. Through her research, she has demonstrated that age-related decline in IGF-1, a neurotrophic factor, impairs cognitive function that correlates with a decline in mitochondrial energy production and increased oxidative stress. Using advanced methodologies, she has made significant advances in addressing and characterizing the heterogeneity in cognitive function that occurs with age. Her lab also has the unique capability of characterizing mice based on their cognitive status (impaired or resilient), which mirrors the inherent susceptibility (or resilience) found in the aging human population. She also performs stereotactic delivery of compounds directly into the hippocampus to investigate localized effects on learning and memory. Logan earned her doctorate in cell biology and completed a postdoctoral fellowship in geriatric medicine, both at the OU College of Medicine.

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Cited By

Year

Simultaneous quantitative respirometry and fluorometric assays in dissected hippocampal tissue from mice

2024

Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning

3

2024

Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages

1

2024

Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice

4

2023

A genetically heterogeneous rat model with divergent mitochondrial genomes

4

2023

Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection

1

2023

Systemic infection of mice with neuroinvasive Listeria monocytogenes triggers cognitive decline and persistent increases in brain CD8+ T-lymphocyte populations

2023

Cognitive heterogeneity reveals molecular signatures of age-related impairment

2

2023

Selective ablation of Sod2 in astrocytes induces sex-specific effects on cognitive function, d-serine availability, and astrogliosis

14

2022

Measuring behavior in the home cage: study design, applications, challenges, and perspectives

59

2021

Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice

2021

IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

47

2021

Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

19

2020

Age-related cognitive impairment: Role of reduced synaptobrevin-2 levels in deficits of memory and synaptic plasticity

20

2020

Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function

30

2020

Accelerated decline in cognition in a mouse model of increased oxidative stress

46

2019

Age-related cognitive impairment: Role of reduced Synaptobrevin-2 levels in the decline of learning and memory and changes in neurotransmission

2019

Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain

14

2019

Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome

37

2018

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice

39

2018

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