Sreemathi Logan, Ph.D., is a faculty member in the Department of Biochemistry and Physiology at the University of Oklahoma College of Medicine and a researcher in the Oklahoma Center for Geroscience and Healthy Brain Aging. At the Center for Geroscience, she also directs the Animal Model Development and Behavioral Analysis (AMD-BA) core as part of the Center of Biomedical Research Excellence (CoBRE) grant. Her career in research has encompassed many aspects of aging, including her early work on Alzheimer’s disease in the initial characterization of the 5x FAD model generated by Dr. Robert Vassar at Northwestern University Chicago. The current focus of her research lab is to pursue mechanisms underlying cognitive dysfunction associated with age and neurodegenerative disorders. More specifically, she is interested in the role of astrocyte mitochondrial metabolism and redox status that alter the astrocytic phenotype and increase gliosis during aging. Through her research, she has demonstrated that age-related decline in IGF-1, a neurotrophic factor, impairs cognitive function that correlates with a decline in mitochondrial energy production and increased oxidative stress. Using advanced methodologies, she has made significant advances in addressing and characterizing the heterogeneity in cognitive function that occurs with age. Her lab also has the unique capability of characterizing mice based on their cognitive status (impaired or resilient), which mirrors the inherent susceptibility (or resilience) found in the aging human population. She also performs stereotactic delivery of compounds directly into the hippocampus to investigate localized effects on learning and memory. Logan earned her doctorate in cell biology and completed a postdoctoral fellowship in geriatric medicine, both at the OU College of Medicine.