Credit: Mohamed Donia, UCSF
A scientific team led by UCSF microbiome expert Michael Fischbach, PhD, identified more than 3,000 clusters of bacterial genes at different body sites that contain the blueprints for cellular factories that make drug-like molecules. One of the molecules discovered based on gene-cluster identification, an antibiotic the researchers named lactocillin, is assembled by enzymes encoded by genes within the circular DNA plasmid of the bacterium, Lactobacillus gasseri, a common resident of the vagina. Lactocillin kills pathogenic bacteria that are found in the vagina, the researchers discovered.