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Medicine

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flu, Influenza, Anthrax, Anthrax Exposure, Drosophila, Lab Experiments, protein transport

Pair of Discoveries Illuminate New Paths to Flu and Anthrax Treatments

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Two recent studies have set the research groundwork for new avenues to treat influenza and anthrax poisoning. The studies employed a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body’s defenses, and possible treatments already developed.

Medicine

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AIDS, HIV, Virus

New Research Opens the Door to ‘Functional Cure’ for HIV

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Scientists have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells.

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Portable 3-D Scanner Assesses Patients with Elephantiasis

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An estimated 120 million people worldwide are infected with lymphatic filariasis, a parasitic, mosquito-borne disease that can cause major swelling and deformity of the legs, a condition known as elephantiasis. Health-care workers rely on leg measurements to assess the severity of the condition. However, measuring legs that are severely swollen often proves cumbersome and impractical. But now, scientists at Washington University School of Medicine in St. Louis, working with collaborators in Sri Lanka, have shown that a portable scanning device can measure limb enlargement and disfigurement faster and more easily in patients with elephantiasis. The research tool makes it easy to obtain accurate measurements and determine whether treatments to reduce swelling are effective.

Medicine

Science

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Neutron Crystallography, Vitamin B6, Antibiotics, Diseases, Tuberculosis, Malaria, Diabetes, Biomedical, Bioenergy, neutron analysis

Neutrons Observe Vitamin B6-Dependent Enzyme Activity Useful for Drug Development

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Scientists at the Department of Energy’s Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria and diabetes. Specifically, the team used neutron crystallography to study the location of hydrogen atoms in aspartate aminotransferase, or AAT, an enzyme vital to the metabolism of certain amino acids.

Medicine

Science

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Nidoviruses, Arteriviruses, Nidovirales, RNA viruses, Simian hemorrhagic fever virus , Margo A. Brinton, possible emerging viruses, National Institutes of Health

Nidoviruses Redundantly Express Genes and Encode More Proteins Than Previously Believed, Study Finds

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Arteriviruses, a family of single-stranded RNA viruses that belongs to the order Nidovirirales, produce more proteins and messenger RNAs than previously reported, a finding that provides important insights about a virus that could potentially evolve to infect humans in the future, according to a new research study.

Medicine

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Influenza, St. Jude Children's Research Hospital, Vaccine, Leukemia, Flu Shot, Acute Lymphoblastic Leukemia

Flu Vaccine Failed to Protect Young Leukemia Patients During Cancer Treatment

St. Jude Children’s Research Hospital investigators said the results reinforce the importance of hand washing and other measures to help protect vulnerable patients from influenza infections.

Medicine

Channels:

Influenza, Viruses, Virology, H7N9, flu, Bird Flu

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 19-Oct-2017 12:00 PM EDT

Medicine

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Food Borne, Food Borne Bacteria, Food Borne Illness, Food Borne Illnesses, Food Borne Infection, Food Borne Pathogens, E. Coli, Salmonella, Bacillus cereus, Shigella, Listeria

What’s Making You Sick: An in-Depth Look at Food-Borne Illnesses

A UAB Infectious Diseases physician discusses bacteria found in food-borne illnesses and why you should wash your hands.

Medicine

Channels:

HIV-1, GP41, AIDS, Envelope Protein, Structural Biology, NMR, Retrovirus

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 19-Oct-2017 12:00 PM EDT

Medicine

Science

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Systems Biology, Genomics, Proteomics, Bioengineering, genome-scale model, Bernhard Palsson, UC San Diego Jacobs School of Engineering

Model Predicts How E. coli Bacteria Adapt Under Stress

Researchers at UC San Diego have developed a genome-scale model that can accurately predict how E. coli bacteria respond to temperature changes and genetic mutations. The work sheds light on how cells adapt under environmental stress and has applications in precision medicine, where adaptive cell modeling could provide patient-specific treatments for bacterial infections.







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