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Article ID: 700863

Cancer Immunotherapy Might Benefit From Previously Overlooked Immune Players

University of California San Diego Health

Using a bioinformatics approach, University of California San Diego School of Medicine researchers found that CD4+ T cell’s binding partner, a molecule called MHC-II, may have even more influence on emerging tumors than MHC-I, the better known partner of CD8+ T cells. The finding, published September 20 in Cell, may help researchers improve cancer immunotherapies and predict which patients will respond best.

Released:
20-Sep-2018 1:05 PM EDT
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  • Embargo expired:
    20-Sep-2018 11:00 AM EDT

Article ID: 700558

Scientists Grow Human Esophagus in Lab

Cincinnati Children's Hospital Medical Center

Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. The newly published research in the journal Cell Stem Cell is the first time scientists have been able to grow human esophageal tissue entirely from pluripotent stem cells (PSCs), which can form any tissue type in the body.

Released:
17-Sep-2018 6:00 AM EDT
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  • Embargo expired:
    20-Sep-2018 11:00 AM EDT

Article ID: 700567

Novel Biomarker Found in Ovarian Cancer Patients Can Predict Response to Therapy

University of Chicago Medical Center

Researchers have identified an independent prognostic factor, cancer/testis antigen 45, that is associated with extended disease-free survival for women with advanced ovarian cancer. Patients with high levels of CT45 in their tumors lived more than seven times as long as patients who lacked sufficient CT45.

Released:
14-Sep-2018 12:05 PM EDT

Article ID: 700772

Anti-inflammatory Protein Promotes Healthy Gut Bacteria to Curb Obesity

University of North Carolina School of Medicine

UNC Scientists discovered the anti-inflammatory protein NLRP12 helps protect mice against obesity and insulin resistance when fed a high-fat diet. The researchers also reported the NLRP12 gene is underactive in people who are obese, making it a therapeutic target for treating obesity and diabetes.

Released:
19-Sep-2018 10:45 AM EDT
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Article ID: 700730

How Cells Repurpose their Garbage Disposal Systems to Promote Inflammation

University of California San Diego Health

Researchers at University of California San Diego School of Medicine have unraveled new insights into the way cells leverage G-protein-coupled receptors (GPCRs) and their cellular waste disposal systems to control inflammation. The findings, published September 18 in Cell Reports, suggest some existing cancer drugs that inhibit these cellular activities might be repurposed to treat vascular inflammation, which occurs when artery-blocking plaques form in atherosclerosis.

Released:
18-Sep-2018 1:05 PM EDT
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Article ID: 700725

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

University of California, Los Angeles (UCLA), Health Sciences

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers.

Released:
18-Sep-2018 12:05 PM EDT

Article ID: 700715

Distance Helps Re-fuel the Heart

Thomas Jefferson University

Separated entry and exit doors for calcium keep energy production smooth in the powerhouses of heart cells.

Released:
18-Sep-2018 11:05 AM EDT
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  • Embargo expired:
    13-Sep-2018 11:00 AM EDT

Article ID: 700321

Caspase-2 Enzyme Inhibition Shows Promise for Ameliorating Fatty Liver Disease

University of California San Diego Health

Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to stop the pathogenic progression that leads to NASH — and possibly even reverse early symptoms.

Released:
11-Sep-2018 11:05 AM EDT
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Article ID: 700342

Changes in Mitochondrial DNA Control how Nuclear DNA Mutations Are Expressed in Cardiomyopathy

Children's Hospital of Philadelphia

Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a nuclear DNA mutation in mice, one mitochondrial variant made heart disease worse, while another variant conferred protection.

Released:
11-Sep-2018 1:45 PM EDT

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