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Newswise: New screening method identifies inhibitors of cancer cell metabolism

New screening method identifies inhibitors of cancer cell metabolism

University of California, Los Angeles (UCLA), Health Sciences

A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell – nucleotide metabolism – to help identify new drugs that specifically and potently block processes that are essential for cancer cell growth.

Channels: All Journal News, Cancer, Cell Biology, Healthcare, Pharmaceuticals, Cell (journal),

Released:
18-Nov-2019 4:30 PM EST
Embargo will expire:
21-Nov-2019 11:00 AM EST
Released to reporters:
18-Nov-2019 4:15 PM EST

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Research Results
Newswise: Master regulator in mitochondria is critical for muscle function and repair

Master regulator in mitochondria is critical for muscle function and repair

Thomas Jefferson University

New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness

Channels: Cell Biology, Neuro, Cell (journal), All Journal News,

Released:
14-Nov-2019 4:35 PM EST
Research Results
  • Embargo expired:
    14-Nov-2019 11:00 AM EST

Genes Borrowed From Bacteria Allowed Plants to Move to Land

University of Alberta

Natural genetic engineering allowed plants to move from water to land, according to a new study by an international group of scientists from Canada, China, France, Germany, and Russia.

Channels: Cell Biology, Chemistry, Evolution and Darwin, Genetics, Plants, Staff Picks, Cell (journal), All Journal News,

Released:
7-Nov-2019 2:55 PM EST
Research Results
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  • Embargo expired:
    14-Nov-2019 11:00 AM EST

Prostate cancer bone metastases thwart immunotherapy by producing TGF-β

University of Texas M. D. Anderson Cancer Center

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that thwarts the effectiveness of immune checkpoint inhibitors. Research points to anti-CTLA-4 and anti-TGF-B combination to protect T cells.

Channels: All Journal News, Bone Health, Cancer, Healthcare, Cell (journal),

Released:
12-Nov-2019 1:35 PM EST
Research Results

Fluorescent probes offer fuller view of drug delivery in cells

Cornell University

Selecting the most effective molecules for drug delivery is often a trial-and-error process, but Cornell engineers are providing some precision thanks to a technique that reveals the performance of those molecules inside living cells.

Channels: All Journal News, Cancer, Cell Biology, Pharmaceuticals, Women's Health, Cell (journal),

Released:
4-Nov-2019 11:05 AM EST
Research Results
Newswise: Kidney Cancer Study Uncovers New Subtypes and Clues to Better Diagnosis and Treatment

Kidney Cancer Study Uncovers New Subtypes and Clues to Better Diagnosis and Treatment

Johns Hopkins Medicine

In what is believed to be the most comprehensive molecular characterization to date of the most common — and often treatment-resistant — form of kidney cancer, researchers at Johns Hopkins’ departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them. Their findings could inform overall patient survival and response to treatment.

Channels: All Journal News, Cancer, Cell Biology, Kidney Disease, Cell (journal), Grant Funded News,

Released:
31-Oct-2019 11:20 AM EDT
Research Results
Newswise: Scientists discover link between unique brain cells and OCD and anxiety
  • Embargo expired:
    22-Oct-2019 11:00 AM EDT

Scientists discover link between unique brain cells and OCD and anxiety

University of Utah

Scientists discovered a new lineage of specialized brain cells, called Hoxb8-lineage microglia, and established a link between the lineage and OCD and anxiety in mice. Their experiments proved that Hoxb8-lineage microglia prevent mice from displaying OCD behaviors and sex hormones drove symptom severity and anxiety.

Channels: All Journal News, Behavioral Science, Cell Biology, Mental Health, Neuro, Psychology and Psychiatry, Staff Picks, Genetics, Cell (journal),

Released:
22-Oct-2019 10:20 AM EDT
Research Results

Social and Behavioral Sciences

Scientists unwind mystery behind DNA replication

Cornell University

The molecules of life are twisted. But how those familiar strands in DNA’s double helix manage to replicate without being tangled up has been hard to decipher. A new perspective from Cornell physicists is helping unravel the mystery.

Channels: All Journal News, Cell Biology, Genetics, Cell (journal),

Released:
17-Oct-2019 1:25 PM EDT
Research Results

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