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Article ID: 710160

Understanding gene interactions holds key to personalized medicine, scientists say

University of Toronto

When the Human Genome Project was completed, in 2003, it opened the door to a radical new idea of health - that of personalized medicine, in which disease risk and appropriate treatment would be gleaned from one's genetic makeup. As more people had their genomes sequenced

Released:
25-Mar-2019 12:05 PM EDT
Embargo will expire:
26-Mar-2019 11:00 AM EDT
Released to reporters:
21-Mar-2019 4:05 PM EDT

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  • Embargo expired:
    21-Mar-2019 11:00 AM EDT

Article ID: 709747

New Evidence Links Lifespan Extension to Metabolic Regulation of Immune System

Joslin Diabetes Center

Researchers at Joslin Diabetes Center have uncovered a new mechanism of lifespan extension that links caloric restriction with immune system regulation.

Released:
18-Mar-2019 12:05 PM EDT
  • Embargo expired:
    12-Mar-2019 11:00 AM EDT

Article ID: 708707

Targeting Stem-Like Cells Could Prevent Ovarian Cancer Recurrence

Health Sciences at the University of Pittsburgh

A new drug takes out the "seeds" that cause ovarian cancer to come back after chemo

Released:
26-Feb-2019 11:00 AM EST
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  • Embargo expired:
    12-Mar-2019 11:00 AM EDT

Article ID: 709293

Scientists Discover Key Enzyme in Breast Cancer Proliferation, Treatment Resistance

University of North Carolina School of Medicine

UNC School of Medicine scientists uncovered a possible reason why some breast cancers are so aggressive and difficult to treat: an enzyme called USP21 promotes proliferation of basal-like breast cancer and is upregulated in a significant percentage of patient tumors. It could become a drug target.

Released:
7-Mar-2019 2:00 PM EST
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  • Embargo expired:
    7-Mar-2019 11:00 AM EST

Article ID: 709073

Researchers Discover a New Mechanism Used by Bacteria to Evade Antibiotics

University of California San Diego

Antibiotics survival mechanism: UC San Diego researchers have discovered an unexpected mechanism that allows bacteria to defend themselves against antibiotics, a surprise finding that could lead to retooled drugs to treat infectious diseases.

Released:
5-Mar-2019 8:00 AM EST
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  • Embargo expired:
    28-Feb-2019 11:00 AM EST

Article ID: 708795

An Atlas of an Aggressive Leukemia

Ludwig Cancer Research

A team of researchers led by Bradley Bernstein at the Ludwig Center at Harvard has used single-cell technologies and machine learning to create a detailed “atlas of cell states” for acute myeloid leukemia (AML) that could help improve treatment of the aggressive cancer.

Released:
27-Feb-2019 11:05 AM EST
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Article ID: 708812

Study reveals structure of 2nd human cannabinoid receptor

Moscow Institute of Physics and Technology (MIPT)

There are two cannabinoid receptors (CB1 and CB2) in the human body that can be targeted to alleviate certain pathological conditions, including chronic pain. While the CB1 receptors are mostly found in the nervous system and are responsible for psychoactive effects, the CB2 receptors are predominantly present in the immune system. Studies indicate that CB2 is a promising target for immunotherapy, as well as treating inflammatory and neuropathic pain, and neurodegenerative diseases. It has also been shown that molecules blocking CB2 can reduce tumor growth.

Released:
27-Feb-2019 2:45 PM EST
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Article ID: 708686

New Clue for Cancer Treatment Could be Hiding in Microscopic Molecular Machine

Florida State University

Researchers discovered that a critical missing step in the production of proteasomes — tiny structures in a cell that dispose of protein waste — and found that carefully targeted manipulation of this step could prove an effective recourse for the treatment of cancer

Released:
26-Feb-2019 9:45 AM EST

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