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Newswise: Recommendations for Interventional Pain Procedures During Contrast Shortage
Released: 24-May-2022 10:05 AM EDT
Recommendations for Interventional Pain Procedures During Contrast Shortage
American Society of Regional Anesthesia and Pain Medicine (ASRA)

Pain medicine practitioners should take measures to reduce the use of iodinated contrast medium in interventional pain procedures due to the current shortage of iohexol. Clinicians are advised to consider using alternate image guidance, such as ultrasound, delaying non-urgent procedures, and using alternative contrast agents, according to guidance just released by ASRA Pain Medicine.

Released: 20-May-2022 3:00 PM EDT
Exploring Online Peer Support Groups for Adults Experiencing Long COVID in the United Kingdom: Qualitative Interview Study
Journal of Medical Internet Research

Background: Long COVID is an emerging public health concern. A growing number of individuals are experiencing prolonged, multifaceted health challenges and accompanying social impacts after COVID-19 infections. Support services in th...

Released: 20-May-2022 2:45 PM EDT
How We Can Reap the Full Benefit of Teleconsultations: Economic Evaluation Combined With a Performance Evaluation Through a Discrete-Event Simulation
Journal of Medical Internet Research

Background: In recent years, the rapid development of information and communications technology enabled by innovations in videoconferencing solutions and the emergence of connected medical devices has contributed to expanding the sco...

Released: 20-May-2022 2:30 PM EDT
Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App–Based Integrated Mental Health Care Model: Cohort Study
Journal of Medical Internet Research

Background: Depression is associated with significant morbidity and human capital costs globally. Early screening for depressive symptoms and timely depressive disorder case identification and intervention may improve health outcomes...

Released: 19-May-2022 2:45 PM EDT
Distinguishing Admissions Specifically for COVID-19 From Incidental SARS-CoV-2 Admissions: National Retrospective Electronic Health Record Study
Journal of Medical Internet Research

Background: Admissions are generally classified as COVID-19 hospitalizations if the patient has a positive SARS-CoV-2 polymerase chain reaction (PCR) test. However, because 35% of SARS-CoV-2 infections are asymptomatic, patients admi...

Released: 19-May-2022 2:45 PM EDT
Online Video Teletherapy Treatment of Obsessive-Compulsive Disorder Using Exposure and Response Prevention: Clinical Outcomes From a Retrospective Longitudinal Observational Study
Journal of Medical Internet Research

Background: Exposure and response prevention, a type of cognitive-behavioral therapy, is an effective first-line treatment for obsessive-compulsive disorder (OCD). Despite extensive evidence of the efficacy of exposure and response p...

Released: 19-May-2022 2:30 PM EDT
The Use of Social Media as a Persuasive Platform to Facilitate Nutrition and Health Behavior Change in Young Adults: Web-Based Conversation Study
Journal of Medical Internet Research

Background: Globally, suboptimal dietary choices are a leading cause of noncommunicable diseases. Evidence for effective interventions to address these behaviors, particularly in young adults, is limited. Given the substantial time y...

Released: 19-May-2022 2:30 PM EDT
Characterization of False or Misleading Fluoride Content on Instagram: Infodemiology Study
Journal of Medical Internet Research

Background: Online false or misleading oral health–related content has been propagated on social media to deceive people against fluoride’s economic and health benefits to prevent dental caries. Objective: The ai...

Released: 19-May-2022 2:15 PM EDT
A Short Intervention and an Interactive e-Learning Module to Motivate Medical and Dental Students to Enlist as First Responders: Implementation Study
Journal of Medical Internet Research

Background: Prompt and proficient basic life support (BLS) maneuvers are essential to increasing the odds of survival after out-of-hospital cardiac arrest. However, significant time can elapse before the arrival of professional rescu...

Released: 17-May-2022 2:45 PM EDT
A Teleconsultation Device, Consult Station, for Remote Primary Care: Multisite Prospective Cohort Study
Journal of Medical Internet Research

Background: Telemedicine technology is a growing field, especially in the context of the COVID-19 pandemic. Consult Station (Health for Development) is the first telemedicine device enabling completely remote medical consultations, i...

Released: 17-May-2022 2:30 AM EDT
Readability of English, German, and Russian Disease-Related Wikipedia Pages: Automated Computational Analysis
Journal of Medical Internet Research

Background: Wikipedia is a popular encyclopedia for health- and disease-related information in which patients seek advice and guidance on the web. Yet, Wikipedia articles can be unsuitable as patient education materials, as investiga...

Released: 17-May-2022 1:45 AM EDT
The Accuracy of Artificial Intelligence in the Endoscopic Diagnosis of Early Gastric Cancer: Pooled Analysis Study
Journal of Medical Internet Research

Background: Artificial intelligence (AI) for gastric cancer diagnosis has been discussed in recent years. The role of AI in early gastric cancer is more important than in advanced gastric cancer since early gastric cancer is not easi...

Released: 16-May-2022 3:00 PM EDT
Use of Robots in Critical Care: Systematic Review
Journal of Medical Internet Research

Background: The recent focus on the critical setting, especially with the COVID-19 pandemic, has highlighted the need for minimizing contact-based care and increasing robotic use. Robotics is a rising field in the context of health c...

Released: 16-May-2022 2:45 PM EDT
The Development and Evaluation of an e-Learning Course That Promotes Digital Health Literacy in School-age Children: Pre-Post Measurement Study
Journal of Medical Internet Research

Background: Experts agree that the promotion of (digital) health literacy should be an integral part of the school curriculum. However, promoting (digital) health literacy within the German school system is difficult because (digital...

Released: 16-May-2022 5:45 AM EDT
Efficacy of azacitidine in preventing relapse after hematopoietic stem cell transplantation for advanced myeloid malignancies: a systematic review and meta-analysis
Expert Review of Hematology

Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …

Released: 16-May-2022 5:45 AM EDT
Treosulfan plus fludarabine versus TEAM as conditioning treatment before autologous stem cell transplantation for B-cell Non-Hodgkin lymphoma
Bone Marrow Transplantation

Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …

Released: 16-May-2022 5:45 AM EDT
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …

Released: 16-May-2022 5:45 AM EDT
PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents
Cell Reports

… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

Released: 16-May-2022 5:45 AM EDT
T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation
Journal of Clinical Immunology

… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …

Released: 13-May-2022 2:45 PM EDT
Monitoring User Opinions and Side Effects on COVID-19 Vaccines in the Twittersphere: Infodemiology Study of Tweets
Journal of Medical Internet Research

Background: In the current phase of the COVID-19 pandemic, we are witnessing the most massive vaccine rollout in human history. Like any other drug, vaccines may cause unexpected side effects, which need to be investigated in a timel...

Released: 13-May-2022 2:30 PM EDT
A Gamified Personalized Normative Feedback App to Reduce Drinking Among Sexual Minority Women: Randomized Controlled Trial and Feasibility Study
Journal of Medical Internet Research

Background: Sexual minority women disproportionately engage in heavy drinking and shoulder the burden of alcohol dependence. Although several intensive interventions are being developed to meet the needs of treatment-seeking sexual m...

Released: 13-May-2022 2:15 PM EDT
Integration of an Intensive Care Unit Visualization Dashboard (i-Dashboard) as a Platform to Facilitate Multidisciplinary Rounds: Cluster-Randomized Controlled Trial
Journal of Medical Internet Research

Background:  Multidisciplinary rounds (MDRs) are scheduled, patient-focused communication mechanisms among multidisciplinary providers in the intensive care unit (ICU). Objective: i-Dashboard is a custom-deve...

Released: 13-May-2022 8:00 AM EDT
Research on Digital Technology Use in Cardiology: Bibliometric Analysis
Journal of Medical Internet Research

Background: Digital technology uses in cardiology have become a popular research focus in recent years. However, there has been no published bibliometric report that analyzed the corresponding academic literature in order to derive k...

Released: 13-May-2022 8:00 AM EDT
Triage Accuracy of Symptom Checker Apps: 5-Year Follow-up Evaluation
Journal of Medical Internet Research

Background: Symptom checkers are digital tools assisting laypersons in self-assessing the urgency and potential causes of their medical complaints. They are widely used but face concerns from both patients and health care professiona...

Released: 13-May-2022 7:00 AM EDT
Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational
Journal of Medical Internet Research

Background: Digital health interventions could help to prevent age-related diseases, but little is known about how older adults engage with such interventions, especially in the long term, or whether engagement is associated with cha...

Released: 13-May-2022 5:45 AM EDT
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
Journal of Tissue Engineering

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …

Released: 13-May-2022 5:45 AM EDT
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Proceedings of the National Academy of Sciences (PNAS)

… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …

Released: 13-May-2022 5:45 AM EDT
Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches
Nature Communications

… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …

Released: 13-May-2022 5:45 AM EDT
Haematopoietic stem cell gene therapy in inborn errors of metabolism
British Journal of Haematology

Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …

Released: 13-May-2022 2:45 AM EDT
The Effects of a Web-Based Tool for Parents of Children With Juvenile Idiopathic Arthritis: Randomized Controlled Trial
Journal of Medical Internet Research

Background: Juvenile idiopathic arthritis (JIA) is a group of autoinflammatory diseases that cause pain and disability if not controlled by treatment. Parenting a child with JIA is stressful for parents, who express concerns about th...

Released: 13-May-2022 2:45 AM EDT
The Influence of Perceived Social Presence on the Willingness to Communicate in Mobile Medical Consultations: Experimental Study
Journal of Medical Internet Research

Background: With the rise of online health care service, there is growing discussion on the relationship between physicians and patients online, yet few researchers have paid attention to patients’ perception of social presence, es...

Released: 13-May-2022 2:45 AM EDT
eHealth Tools That Assess and Track Health and Well-being in Children and Young People: Systematic Review
Journal of Medical Internet Research

Background: eHealth tools that assess and track health outcomes in children or young people are an emerging type of technology that has the potential to reform health service delivery and facilitate integrated, interdisciplinary care...

Released: 13-May-2022 2:30 AM EDT
Improving Research Patient Data Repositories From a Health Data Industry Viewpoint
Journal of Medical Internet Research

Organizational, administrative, and educational challenges in establishing and sustaining biomedical data science infrastructures lead to the inefficient use of Research Patient Data Repositories (RPDRs). The challenges, including but not limited to ...

Released: 13-May-2022 2:00 AM EDT
Multimodal Chronic Pain Therapy for Adults via Smartphone: Randomized Controlled Clinical Trial
Journal of Medical Internet Research

Background: Combination therapies delivered remotely via the internet or mobile devices are increasingly being used to improve and promote the self-management of chronic conditions. However, little is known regarding the long-term ef...

Released: 12-May-2022 3:00 PM EDT
The Effectiveness of a Computer-Tailored Web-Based Physical Activity Intervention Using Fitbit Activity Trackers in Older Adults (Active for Life): Randomized Controlled Trial
Journal of Medical Internet Research

Background: Physical activity is an integral part of healthy aging; yet, most adults aged ≥65 years are not sufficiently active. Preliminary evidence suggests that web-based interventions with computer-tailored advice and Fitbit ac...

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Released: 12-May-2022 12:05 PM EDT
New Tech Can Double Spectral Bandwidth in Some 5G Systems
Washington University in St. Louis

Using the properties of a unique class of materials, researchers, including Aravind Nagulu at the McKelvey School of Engineering, may have found a way to dramatically increase the bandwidth available for wireless communications.

Released: 12-May-2022 5:00 AM EDT
Risk prediction of CMV reactivation after allogeneic stem cell transplantation using five non-HLA immunogenetic polymorphisms
Annals of Hematology

Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV) infection, it remains as one of the most common infectious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …

Released: 11-May-2022 5:00 AM EDT
Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering
Developmental Biology

… Also, and most importantly, when comparing results across laboratories we need to bear in mind that no embryonic stem cell line is a tabula rasa. Different cell lines have been shown to exhibit biases in differentiation potential (Ortmann et al., 2020) …

Released: 11-May-2022 5:00 AM EDT
β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling
American Journal of Cancer Research

Multi-drug resistance remains a critical issue in cancer treatment that hinders the effective use of chemotherapeutic drugs. The active components of traditional Chinese medicine have been applied as adjuvants to accentuate the anticancer …

Newswise: Treatment Efficacy Score a Better Way to Predict Long-Term Survival in Breast Cancer Trials
Released: 10-May-2022 10:05 AM EDT
Treatment Efficacy Score a Better Way to Predict Long-Term Survival in Breast Cancer Trials
Yale Cancer Center

In a study led by Dr. Lajos Pusztai, Professor of Medicine (Medical Oncology) at Yale Cancer Center, researchers across various institutions, and on behalf of the I-SPY consortium, developed a novel continuous residual cancer based metric to compare neoadjuvant chemotherapy efficacy between randomized trial arms in preoperative breast cancer trials.

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