One of the methods scientists use to study quantum many-body systems is the ab initio approach, but some ab initio methods run into severe computational problems when using realistic interactions. This study introduces wavefunction matching and uses it to perform lattice simulations with realistic interactions. This allows scientists to make calculations that were once impossible.
Ludwig Cancer Research scientists have developed a full, start-to-finish computational pipeline that integrates multiple molecular and genetic analyses of tumors and the specific molecular targets of T cells and harnesses artificial intelligence algorithms to use its output to design personalized cancer vaccines for patients.
New research conducted at Argonne National Laboratory shows that colloidal quantum shells could revolutionize the production of X-ray imaging scintillators.
Inflammation of the arteries is a primary precursor and driver of cardiovascular disease — the No. 1 killer of people in the United States. This inflammation is associated with the buildup of dangerous plaque inside the arteries. Advanced treatments are needed to target this inflammation in patients. Michigan State University researchers have tested a new nanoparticle nanotherapy infusion that precisely targets inflammation and activates the immune system to help clear out arterial plaque.
Results of the first phase of a Ceramide Ring Trial have just been published in the renowned journal Nature Communications, representing a significant landmark in the field of lipidomics.
Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus chemotherapy to overcome treatment resistance typically seen in this patient population.
Researchers have identified a new genetic marker that could play a role in the development of Alzheimer's disease and lead to novel therapeutic targets and diagnostic tools for the disease.
A recent study published in Nature Geoscience provides groundbreaking insights into long-term changes in tropical weather patterns that are leading to an increased frequency of extreme weather events such as heatwaves and heavy rainfall in the Indo-Pacific. These changes are possibly driven by global warming, among other factors. The paper, titled “Indo-Pacific regional extremes aggravated by changes in tropical weather patterns”, employs a recently proposed methodology that characterises occurrence trends of weather patterns using atmospheric analogues, which are linked to the concept of recurrences in dynamical systems theory.
After nearly doubling over the 20th century, the rate of increase in life expectancy has slowed considerably in the last three decades, according to a new study led by the University of Illinois Chicago.
Researchers have mapped pancreatic cancer tumor ecosystems using tissue from both the primary tumor and metastatic disease. The study uncovers notable differences that could lead to new treatment strategies for the often-deadly disease.
The lab of Jason Stein, PhD, associate professor of genetics and member of the UNC Neuroscience Center, has created a controlled model system that could help researchers know more about the genetic variants that increase one’s risk for developing a psychiatric disorder.
As AI is deployed in clinical centers across the U.S., one important consideration is to assure that models are fair and perform equally across patient groups and populations. To better understand the fairness of medical imaging AI, a team of researchers trained over 3,000 models spanning multiple model configurations, algorithms, and clinical tasks.
Rodolfo Cortes Barragan, research scientist the University of Washington Institute for Learning and Brain Sciences (I-LABS), and Andrew Meltzoff, co-director of I-LABS and professor of psychology, recently co-authored a study in Nature Scientific Reports showing a link between the ability to see the stars unblocked by light pollution and an interest in astronomy.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Using NASA’s James Webb Space Telescope, a team of astronomers observed Centaur 29P/Schwassmann-Wachmann 1, one of the most active and intriguing objects in the outer solar system. The high degree of detail captured by the telescope led to the discovery of new, previously unknown jets of gas, which is helping inform theories about how centaurs and planets are formed.
A study by researchers at WashU Medicine shows that respiratory viruses can hide out in immune cells in the lungs long after the initial symptoms of an infection have resolved, creating a persistently inflammatory environment that promotes the development of chronic lung diseases such as asthma.
A Cleveland Clinic-led research collaboration between Timothy Chan, MD, PhD, Chair of Cleveland Clinic’s Global Center for Immunotherapy, and Bristol Myers Squibb has published the most comprehensive overview to date of how our immune system reshapes tumor architecture in response to immune checkpoint therapy. The eight-year study, published in Nature Medicine, outlines how cancer immunotherapy induces tumor recognition through neoantigens to reshape the tumor ecosystem.
The complex shape of respiratory syncytial virus is one hurdle limiting the development of treatments for an infection that leads to hospitalization or worse for hundreds of thousands of people in the United States each year, according to the Centers for Disease Control and Prevention. New images of the virus from researchers at the University of Wisconsin–Madison may hold the key to preventing or slowing RSV infections.
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