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Newswise: Preclinical Study Shows Targeted Drug Strengthens the Power of CAR T-Cell Therapy in Two Pediatric Leukemias
Released: 7-Dec-2024 7:00 PM EST
Preclinical Study Shows Targeted Drug Strengthens the Power of CAR T-Cell Therapy in Two Pediatric Leukemias
Roswell Park Comprehensive Cancer Center

A preclinical study led by a faculty member at Roswell Park Comprehensive Cancer Center shows that gilteritinib (brand name Xospata), a targeted cancer treatment, can strengthen chimeric antigen receptor (CAR) T-cell immunotherapy in two high-risk pediatric leukemias that have poor survival rates — FLT3-mutated acute myeloid leukemia (AML) and KMT2A-rearranged acute lymphoblastic leukemia (ALL). Lisa Niswander, MD, PhD, Assistant Professor of Oncology in the Department of Pediatric Oncology, will deliver the results this afternoon in an oral abstract session at the 66th annual meeting of the American Society of Hematology (ASH) in San Diego, California.

Newswise: Roswell Park Study Reveals How Venetoclax Boosts Immune Response to CAR T for Chronic Lymphocytic Leukemia
7-Dec-2024 12:30 PM EST
Roswell Park Study Reveals How Venetoclax Boosts Immune Response to CAR T for Chronic Lymphocytic Leukemia
Roswell Park Comprehensive Cancer Center

Research out of Roswell Park Comprehensive Cancer Center has shed light on how the drug venetoclax (brand name Venclexta) works synergistically with CAR T-cell immunotherapy to combat chronic lymphocytic leukemia (CLL), the most common type of leukemia in the U.S. Matthew Cortese, MD, MPH, Assistant Professor of Oncology in Roswell Park’s departments of Medicine and Cancer Genetics & Genomics, is first author of the study, which he will present during an oral abstract session today at the 66th annual meeting of the American Society of Hematology (ASH) in San Diego, California.

5-Dec-2024 9:00 AM EST
Keto Diet Metabolite May Power Up CAR T Cells to Kill Cancer
Perelman School of Medicine at the University of Pennsylvania

A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center, presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition (Abstract 4).

Newswise: New Research from Children’s Hospital of Philadelphia to Transform Standard of Care Across the Globe for Newly Diagnosed Children with B-cell Acute Lymphoblastic Leukemia
Released: 7-Dec-2024 10:00 AM EST
New Research from Children’s Hospital of Philadelphia to Transform Standard of Care Across the Globe for Newly Diagnosed Children with B-cell Acute Lymphoblastic Leukemia
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) and the Children’s Oncology Group (COG) announced the results of a Phase 3 study that demonstrated adding the bi-specific T-cell engager, blinatumomab, to chemotherapy for newly diagnosed National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL) pediatric patients significantly improves survival outcomes. The results were published today in the New England Journal of Medicine and will be presented during the plenary session at the 66th American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego on December 8.

Newswise: Thawing Permafrost Reveals Complex Microbiome–Metabolite Interplay
Released: 6-Dec-2024 5:50 PM EST
Thawing Permafrost Reveals Complex Microbiome–Metabolite Interplay
Environmental Molecular Sciences Laboratory - EMSL

Research led by a multi-institutional study found that microbes interact with sulfur- and nitrogen-rich compounds, possibly from mosses in bogs. This interaction appears to contribute to greenhouse gas production.

Newswise: Illinois Research Illuminates Signal Transduction Mechanisms in Cys-loop Receptors
Released: 6-Dec-2024 5:10 PM EST
Illinois Research Illuminates Signal Transduction Mechanisms in Cys-loop Receptors
College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign

University of Illinois researchers discovered a key factor responsible for facilitating signal transduction in Cys-loop receptors, providing insight into a longstanding question in the field of ion-channel physiology and contributing to rational drug design.

Newswise: Calculation Sharpens Imaging of Protons’ Insides
Released: 6-Dec-2024 3:15 PM EST
Calculation Sharpens Imaging of Protons’ Insides
Department of Energy, Office of Science

Nuclear scientists used a new theoretical approach to calculate a value essential for unraveling the three-dimensional motion of quarks within a proton. The researchers obtained a significantly more accurate picture of these internal building blocks’ transverse motion. The work will aid in calculations of 3D motion of quarks and gluons in future collider experiments.

Newswise: UAlbany Chemists Develop Color-Changing Test for Rapid Salmonella Detection
Released: 6-Dec-2024 1:55 PM EST
UAlbany Chemists Develop Color-Changing Test for Rapid Salmonella Detection
University at Albany, State University of New York

UAlbany researchers have developed a new method for fast-acting salmonella detection. The test employs a paper strip that changes color in the presence of the bacterial genome, enabling quick, easy and inexpensive screening for salmonella in food products.

Released: 6-Dec-2024 1:20 PM EST
Researchers Develop New Shape-Changing Polymer
Ohio State University

A team of scientists has created a new shape-changing polymer that could transform how future soft materials are constructed.

Newswise: Record-Low Antarctic Sea Ice Can Be Explained and Forecast Months Out by Patterns in Winds
Released: 6-Dec-2024 12:50 PM EST
Record-Low Antarctic Sea Ice Can Be Explained and Forecast Months Out by Patterns in Winds
University of Washington

University of Washington researchers show that the all-time record low in winter sea ice extent in 2023 can be explained by warm Southern Ocean conditions and patterns in the winds that circled Antarctica months earlier, allowing forecasts for sea ice coverage around the South Pole to be generated six or more months in advance. This could support regional and global weather and climate models.


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