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Article ID: 713255

Massive sequencing study links rare DNA alterations to type 2 diabetes

University of Michigan

An international consortium of scientists has analyzed protein-coding genes from nearly 46,000 people, linking rare DNA alterations to type 2 diabetes.

Released:
22-May-2019 2:00 PM EDT
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Article ID: 713324

Vascular Surgeon Makes Discovery that Saves Brooklyn Man’s Foot

NYU Langone Hospital - Brooklyn

Sheila Blumberg, MD, a vascular surgeon at NYU Langone Hospital–Brooklyn, used advanced surgical techniques to save the foot of Brooklyn native Jose Palacios.

Released:
22-May-2019 11:05 AM EDT
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  • Embargo expired:
    20-May-2019 3:00 PM EDT

Article ID: 713141

Circadian Mechanism May Not Be Driver Behind Compound Linked to Obesity and Diabetes

Perelman School of Medicine at the University of Pennsylvania

SR9009 is a compound that can lead to a wide range of health benefits in animals, including reduced risk of obesity and type 2 diabetes. Until now, researchers have attributed the effects to SR9009’s role in altering the body’s circadian clock. However, in a first-of-its-kind study from Penn Medicine, published today in PNAS, researchers found that SR9009 can effect cell growth and metabolic function without the involvement of REV-ERBs.

Released:
20-May-2019 10:05 AM EDT
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Article ID: 713185

Study identifies enzymes that prevent diabetic kidney disease

Joslin Diabetes Center

BOSTON -- (May 13, 2019) -- A new study from Joslin Diabetes Center has proven that certain biological protective factors play a large role in preventing diabetic kidney disease in certain people. The study was published today in Diabetes Care. This study built on the findings from a 2017 Joslin Medalist Study of protective factors and diabetic kidney disease (or DKD).

Released:
20-May-2019 1:05 PM EDT
Embargo will expire:
22-May-2019 5:00 PM EDT
Released to reporters:
20-May-2019 12:05 PM EDT

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Article ID: 713158

Key Drug Target Shown Assembling in Real-Time

Case Western Reserve University

Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout the body—but a recent study shows what happens next. In results published in Cell, researchers outline the timeline of events, including precisely when and how different parts of a GPCR interacts with its G protein signaling partners. The findings provide new insights into the fundamental mechanisms of drug-induced signaling in cells, including ways to identify the most critical portions of GPCRs for targeting development of novel therapeutics.

Released:
20-May-2019 11:05 AM EDT
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Article ID: 713138

Discovery in mice could help remove roadblock to more insulin production

Michigan Medicine - University of Michigan

A new discovery made mainly in mice could provide new options for getting the insulin-making "factories" of the pancreas going again when diabetes and obesity have slowed them down. It could offer new pathways to ramping up insulin supply to get metabolism back on track in people with Type 1 and Type 2 diabetes, and obesity.

Released:
20-May-2019 11:05 AM EDT
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  • Embargo expired:
    16-May-2019 4:30 PM EDT

Article ID: 712672

Ultrasound Used To Trigger Insulin Release in Mice Shows Promise for Future Diabetes Therapy

Acoustical Society of America (ASA)

Current treatments of Type 2 diabetes can help the body use insulin at various stages of the disease, but they can also be expensive and subject patients to lifelong medication regimens and side effects. Thanks to new therapeutic ultrasound technology, one promising alternative looks to reshape how early Type 2 diabetes is managed. A group of researchers has used ultrasound therapy to stimulate insulin release from mice on demand. The team will present their findings at the 177th ASA Meeting, May 13-17.

Released:
10-May-2019 11:20 AM EDT
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  • Embargo expired:
    14-May-2019 11:00 AM EDT

Article ID: 712681

Philadelphia’s Sweetened Drink Sales Drop 38 Percent after Beverage Tax

Perelman School of Medicine at the University of Pennsylvania

One year after Philadelphia passed its beverage tax, sales of sugary and artificially sweetened beverages dropped by 38 percent percent in chain food retailers, according to Penn Medicine researchers who conducted one of the largest studies examining the impacts of a beverage tax. The results, published this week in JAMA, translate to almost one billion fewer ounces of sugary or artificially sweetened beverages – about 83 million cans of soda – purchased in the Philadelphia area. The findings provide more evidence to suggest beverage taxes can help reduce consumption of sugary drinks, which are linked to the rise in obesity and its related non-communicable diseases, such as type II diabetes.

Released:
9-May-2019 4:05 PM EDT

Law and Public Policy

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  • Embargo expired:
    9-May-2019 7:00 PM EDT

Article ID: 712547

Queen’s University Belfast researchers discover revolutionary stem cell treatment for vascular disease

Queen's University Belfast

*For the first time, researchers have developed a non-intrusive way to generate large quantities of stem cells using only a small amount of blood* *The stem cells can repair cells damaged as a result of vascular diseases, which has the potential to prevent blindness and reverse the need for amputations*

Released:
8-May-2019 10:05 AM EDT

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