A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer progression. Moffitt Cancer Center researchers have found new insights into how metabolic changes associated with aging can impact immune responses against tumors.
Researchers at WashU Medicine collaborated with an international team of doctors and scientists to identify the cause of a rare disorder involving intellectual disability and brain malformations. The team found a link between the child’s neurological symptoms and a genetic change that affects how proteins are properly folded within cells, providing the parents with a molecular diagnosis and identifying an entirely new type of genetic disorder. The findings are published in Science.
The Amyloidosis Research Consortium (ARC) is proud to announce the launch of its Clinical Fellowship Program, designed to enhance the education and development of the next generation of amyloidosis specialists.
Researchers have developed a compact, wearable ultrasound device that monitors muscle activity. Attachable to the skin with an adhesive and powered by a small battery, the device wirelessly captures high-resolution images of muscle movements, enabling continuous, long-term monitoring. When worn on the rib cage, it effectively monitored diaphragm function for respiratory health assessments. When worn on the forearm, it accurately captured hand gestures, allowing users to control a robotic arm and even navigate virtual games. This new technology has potential applications in healthcare for conditions affecting muscle function, as well as in human-machine interfaces for more natural robotic control.
By poring over decades worth of data, researchers hope to better determine how pesticides, metals, and exposures to other elements impact Alzheimer’s disease risk
Researchers at WashU Medicine have found a process by which the brain guards against attack by the immune system. In mice with multiple sclerosis, such "guardian" proteins that train the immune system were drastically depleted, and replenishing them improved symptoms, according to a study in Nature.
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health sheds light on how the blood-borne parasite that causes African sleeping sickness in humans and related diseases in cattle and other animals establishes long-term infections in hosts. Using a mouse model, the researchers showed thatTrypanosoma brucei essentially plays a game of hide-and-seek by setting up shop in its hosts’ tissues, allowing it to constantly change its protective surface coat and evade antibodies.
Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) found that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause mortality, intracranial hemorrhage, major bleeding, clinical deterioration and/or escalation to bailout therapy, and postprocedural ICU admission and length of stay. Findings were reported today at TCT 2024, the annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. Results were also published simultaneously in Circulation.
Mount Sinai study shows how the heart and brain interact to influence sleep patterns and help with recovery
Results from the large-scale randomized ECLIPSE trial found that a lesion preparation strategy of routine orbital atherectomy had similar outcomes compared with conventional balloon angioplasty prior to implantation of a drug-eluting stent (DES) in severely calcified coronary arteries.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance. The study, published in the October 30 online issue of Cell used a cutting-edge spatial genomics technology and preclinical animal models, with tumor specimens from ovarian cancer patients further validating the findings. They found that ovarian cancer cells produce a molecule called Interleukin-4 (IL-4), which is typically associated with asthma and the skin condition eczema, also known as atopic dermatitis. The study went on to find that the cancer cells used IL-4 to create a protective environment that kept away killer immune cells, making the tumors resistant to immunotherapy. A drug, dupilumab, which blocks IL-4’s activity, has been approved by the Food and Drug Administration (FDA) and is already used to treat asthma and eczema. This new study suggests dupi
An international team of geoscientists led by a volcanologist at Rutgers University-New Brunswick has discovered that, contrary to present scientific understanding, ancient volcanoes continued to spew carbon dioxide into the atmosphere from deep within the Earth long past their period of eruptions.
Typical diagnosis of upper urinary tract cancers requires removal of suspicious tissue with forceps, a technically challenging procedure that only samples one region of the organ. NIBIB-funded researchers are developing preclinical microgrippers that could be deployed throughout the upper urinary tract, which could potentially grab tiny pieces of tissue at hundreds of different areas and someday facilitate early detection of disease.
RIPE researchers found that modern soybean plants have increased mesophyll conductance compared to ancestral soybean plants. Their work was recently published in Plant, Cell and Environment.
Dr. Avimanyu Sahoo, a researcher at The University of Alabama in Huntsville (UAH), has been awarded a National Science Foundation (NSF) award totaling $299,969 to characterize the vulnerability of the learning-based intelligent cyber-physical systems (CPS) and defend them. The CPS represents a symbiotic integration of physical systems, sensors, actuators and learning-based intelligent controllers through communication networks such as smart grids, robotic swarms and autonomous vehicles.
New research from University of Utah Health has identified a promising target for new antimalarial drugs: a protein called DMT1, which allows single-celled malaria parasites to use iron. Preventing DMT1 activity causes parasites to die unusually quickly.
The University of Pennsylvania School of Nursing (Penn Nursing) has been awarded a $3.2 million, 5-year grant from the National Institute of Nursing Research (NINR) to scale out an evidence-based secure firearm storage intervention at Children’s Hospital of Philadelphia (CHOP). Firearms are now the leading cause of death for U.S. children and teens, driving the largest spike in children’s mortality in more than 50 years. The study aims to keep children safer from firearm injury and mortality by promoting secure firearm storage.
A grant from the National Institutes of Health will help Wayne State University researchers explore new avenues for using computer models to produce medications.
Rensselaer Polytechnic Institute’s Christopher Cioffi, Ph.D., Thomas and Constance D'Ambra Professor in Organic Chemistry, has been collaborating with Konstantin Petrukhin, Ph.D., Professor of Ophthalmic Science at Columbia University, to develop compounds to treat dry age-related macular degeneration (AMD) and Stargardt disease — both blindness-causing diseases. The team’s work has led to the discovery of an advanced preclinical candidate. Now, Cioffi and Petrukhin have received a $6.4 million grant over five years from the National Institutes of Health’s National Eye Institute to conduct drug development work and investigational new drug (IND)-enabling toxicology studies.
In a significant advance against the growing threat of antibiotic-resistant bacteria, , researchers have identified a novel class of antimicrobial agents known as encrypted peptides, which may expand the immune system’s arsenal of tools to fight infection.
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