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  • Embargo expired:
    10-Oct-2018 5:00 PM EDT

Article ID: 701795

Cancer Patients with Rare Deadly Brain Infection Treated Successfully with Off-the-Shelf Adoptive T-Cell Therapy in Clinical Trial

University of Texas M. D. Anderson Cancer Center

An emerging treatment known as adoptive T-cell therapy has proven effective in a Phase II clinical trial for treating progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection sometimes observed in patients with cancer and other diseases in which the immune system is compromised. The study, led by Katy Rezvani, M.D., Ph.D., professor, Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center, showed marked improvement in three PML patients infused with donor T cells targeting the BK virus. Findings were published in the Oct. 11 online issue of the New England Journal of Medicine.

9-Oct-2018 5:00 PM EDT

Article ID: 701772

Study Finds Tiny Clip That Repairs Leaky Heart Valve is a Powerful Treatment Option for Heart Failure Patients

Intermountain Medical Center

A new nationwide study has found that a tiny clip placed in the heart to fix a leaky mitral valve drastically decreases the risk of both dying and returning to the hospital for heart failure patients.

8-Oct-2018 5:30 AM EDT
  • Embargo expired:
    3-Oct-2018 5:00 PM EDT

Article ID: 701543

Kidney Care Conflicts of Interest: Penn Medicine Experts Call for Transparency on Joint-Venture Dialysis Clinics

Perelman School of Medicine at the University of Pennsylvania

Penn Medicine experts in nephrology and health policy call for more transparency about joint-venture ownership of dialysis clinics to better understand what impact these arrangements may have on patient referrals and clinical outcomes. The lack of transparency poses a major barrier for evidence-based health care policy research and deprives patients of critical information, the researchers write in a new Perspective published in the New England Journal of Medicine.

3-Oct-2018 11:00 AM EDT

Article ID: 701241

Non-Small Cell Lung Cancer Patients See Improved Survival with Durvalumab

Moffitt Cancer Center

Non-small cell lung cancer patients survive longer when their treatment includes durvalumab following platinum-based chemoradiotherapy, according to research led by Moffitt Cancer Center. New clinical trial data published this week in The New England Journal of Medicine show durvalumab improved progression-free survival by 17.2 months compared to placebo.

27-Sep-2018 11:05 AM EDT

Article ID: 700964

Transcatheter Device Used to Treat Secondary Mitral Valve Regurgitation in Heart Failure Patients Reduces Hospitalizations, Enhances Quality of Life, and Improves Survival

Cardiovascular Research Foundation (CRF)

Data presented today from the randomized COAPT trial, which have the potential to significantly change current clinical practice, found that patients with heart failure and secondary mitral regurgitation (MR) who remained symptomatic despite maximally tolerated medical therapy demonstrated reduced rates of hospitalizations and death, as well as improved quality-of-life and functional capacity after being treated with the transcatheter MitraClip device.

23-Sep-2018 3:05 PM EDT
  • Embargo expired:
    23-Sep-2018 1:20 PM EDT

Article ID: 700754

Minimally Invasive Procedure Significantly Improved Outcomes for Heart Failure Patients with Mitral Regurgitation

New York-Presbyterian Hospital

A multicenter clinical trial has found that a minimally invasive procedure called transcatheter mitral valve repair significantly reduced hospitalizations and mortality for heart failure patients with moderate-to-severe or severe functional mitral regurgitation.

22-Sep-2018 1:20 PM EDT
  • Embargo expired:
    16-Sep-2018 10:00 AM EDT

Article ID: 700606

Aspirin Found Not to Prolong Healthy Aging

Rush University Medical Center

Taking a low-dose aspirin daily does not prolong healthy living in older adults, according to findings from the ASPirin in Reducing Events in the Elderly (ASPREE) trial published online Sept. 16 in three papers in The New England Journal of Medicine.

14-Sep-2018 5:00 PM EDT
  • Embargo expired:
    12-Sep-2018 5:00 PM EDT

Article ID: 700290

Genetic Testing Helps Predict Disease Recurrence in Myelodysplastic Syndrome

Washington University in St. Louis

A DNA-based analysis of blood cells soon after a stem cell transplant can predict likelihood of disease recurrence in patients with myelodysplastic syndrome (MDS), a group of cancerous disorders characterized by dysfunctional blood cells, according to new research at Washington University School of Medicine in St. Louis. Such a practice could help doctors identify patients at high risk of disease recurrence early after a transplant and help guide treatment decisions.

10-Sep-2018 7:05 PM EDT
  • Embargo expired:
    12-Sep-2018 5:00 PM EDT

Article ID: 700414

NEJM Perspective: How State Attorneys General Can Protect Public Health

New York University

To protect the public from harmful products, legal action can be used against industries, one example of which—a settlement with the tobacco industry—offers useful lessons for confronting several of today’s public health epidemics.

12-Sep-2018 1:00 PM EDT

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