Curated News: NEJM

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This news release is embargoed until 25-Feb-2024 1:45 PM EST Released to reporters: 21-Feb-2024 12:00 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 25-Feb-2024 1:45 PM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Released: 12-Feb-2024 11:05 AM EST
Antibody drug conjugates make strides in ovarian cancer with recent FDA approval
University of California, Los Angeles (UCLA), Health Sciences

The UCLA team played a pivotal role in a clinical trial that led to the FDA granting accelerated approval of the first antibody drug conjugate (ADC), mirvetuximab soravtansine, for the treatment of platinum-resistant ovarian cancer.

Newswise: International Study Finds Thrombectomy Highly Effective Long-Term Treatment for Large Strokes
9-Feb-2024 9:05 AM EST
International Study Finds Thrombectomy Highly Effective Long-Term Treatment for Large Strokes
University Hospitals Cleveland Medical Center

In a major, international study, named SELECT2, a University Hospitals (UH) research team found that patients with large strokes had a dramatically better recovery after endovascular thrombectomy plus medical management at long-term follow-up, than patients who only received standard medical management.

Released: 7-Feb-2024 5:10 PM EST
UTHealth Houston report in NEJM: Deadly fungal infection acquired during surgery in Mexico led to death and brainstem, blood supply injuries
University of Texas Health Science Center at Houston

A life-threatening mold infection known as health care-associated Fusarium solani meningitis can be associated with a delayed, but devastating, injury to the brainstem and its blood supply among those infected, according to physicians from UTHealth Houston.

Released: 2-Feb-2024 11:05 AM EST
Gene-editing offers hope for people with hereditary disorder
University of Auckland

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

Newswise: Large Multicenter Clinical Trial Finds that Antiseptic Containing Iodine Reduces Surgical-Site Infections in Patients with Extremity Fractures
Released: 1-Feb-2024 7:00 AM EST
Large Multicenter Clinical Trial Finds that Antiseptic Containing Iodine Reduces Surgical-Site Infections in Patients with Extremity Fractures
University of Maryland Medical Center

A large multicenter clinical trial co-led by University of Maryland School of Medicine researchers found that an antiseptic containing iodine resulted in about one-quarter fewer post-surgical infections in patients with limb fractures compared to another frequently used skin antiseptic.

29-Jan-2024 10:05 AM EST
Surgeons’ choice of skin disinfectant impacts infection risk, Canadian-American study shows
McMaster University

Researchers of the PREPARE trial, which enrolled nearly 8,500 participants at 25 hospitals in Canada and the United States, found the use of iodine povacrylex in alcohol to disinfect a patient’s skin could prevent surgical site infection in thousands of patients undergoing surgery for a closed fracture each year.

17-Jan-2024 5:00 AM EST
CD19-targeted CAR NK cell therapy achieves promising one-year results in patients with B-cell malignancies
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center reported promising results in a Phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19.

Newswise: About 22 high school age adolescents died each week from overdoses in 2022, driven by fentanyl-laced prescription pills
5-Jan-2024 5:05 PM EST
About 22 high school age adolescents died each week from overdoses in 2022, driven by fentanyl-laced prescription pills
University of California, Los Angeles (UCLA), Health Sciences

Embargoed research finds an average of 22 adolescents 14 to 18 years of age died in the U.S. each week in 2022 from drug overdoses, raising the death rate for this group to 5.2 per 100,000-- driven by fentanyl in counterfeit pills. The researchers also found 19 "hotspot" counties with particularly high overdose deaths.

Released: 5-Jan-2024 3:05 PM EST
UC Davis Health creates road map to diversify health care workforce
UC Davis Health

In a new case study published in New England Journal of Medicine Catalyst’s January 2024 issue, UC Davis Health shared a road map for increasing workforce diversity across the health care industry.

Released: 4-Jan-2024 4:05 PM EST
A blood test can identify genetic diseases in fetuses
University of Southern Denmark

A research team from Odense University Hospital and the University of Southern Denmark has developed an innovative screening test. With a blood sample from the expectant mother, they can scrutinize all the genes in the fetus.

Newswise: Gorelick_David.jpg
Released: 19-Dec-2023 4:05 PM EST
UM School of Medicine Review Highlights Rise in Psychiatric Disorders Linked to Increased Cannabis Use
University of Maryland School of Medicine

The widespread use of cannabis (marijuana) and its increased potency are associated with a rise in cannabis-related psychiatric conditions, according to a new University of Maryland School of Medicine (UMSOM) review article that was recently published in the New England Journal of Medicine. It highlights the urgent need for doctors to screen for and treat patients who are experiencing symptoms of cannabis use disorder, which means they are experiencing significant problems from their use of the drug.

Released: 7-Dec-2023 5:05 PM EST
World-first trial offers new hope for type 1 diabetes
ST Vincent's Institute Of Medical Research

Researchers at St Vincent’s Institute of Medical Research (SVI) in Melbourne have shown that a commonly prescribed rheumatoid arthritis drug can suppress the progression of type 1 diabetes.   The world-first human trial, published today in the New England Journal of Medicine and led by SVI’s Professor Thomas Kay, showed that a drug called baricitinib can safely and effectively preserve the body’s own insulin production and suppress the progression of type 1 diabetes in people who initiated treatment within 100 days of diagnosis.

Newswise: Long-standing hormone treatment for donated hearts found to be ineffective
28-Nov-2023 2:05 PM EST
Long-standing hormone treatment for donated hearts found to be ineffective
Washington University in St. Louis

A study from Washington University School of Medicine in St. Louis and Mid-America Transplant showed that the long-standing practice of treating deceased organ donors with thyroid hormone does not help preserve heart function, may cause harm and should be discontinued.

Released: 16-Nov-2023 12:05 PM EST
Excessive fluid consumption: habit or hormonal disorder?
University of Basel

Researchers found that a test using salt infusion is more reliable than a test using arginine infusion to differentiate between excessive fluid ingestion and vasopressin deficiency.

Not for public release

This news release is embargoed until 12-Nov-2023 8:45 AM EST Released to reporters: 9-Nov-2023 12:05 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 12-Nov-2023 8:45 AM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

11-Nov-2023 10:10 AM EST
Transfusing More Blood May Benefit Patients Who Have Had Heart Attack and Have Anemia
Rutgers University-New Brunswick

An international clinical trial led by physician Jeffrey L. Carson, distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School, found that a liberal blood transfusion given to patients who have had a heart attack and have anemia may reduce the risk of a reoccurrence and improve survival rates.

Newswise: NEJM: Study Supports Minimally Invasive Procedure for Aortic Stenosis
Released: 24-Oct-2023 6:05 PM EDT
NEJM: Study Supports Minimally Invasive Procedure for Aortic Stenosis
Cedars-Sinai

Patients with a dysfunctional aortic heart valve who received a new, prosthetic valve through a minimally invasive procedure had similar outcomes at five years as those who underwent open-heart surgery, a new study shows.

Newswise: Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
20-Oct-2023 6:00 PM EDT
Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
University of Texas MD Anderson Cancer Center

A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.

Newswise: FDA Approves Minimally Invasive Therapy Shown to Save the Legs of Severe Vascular Disease Patients from Amputation
Released: 12-Sep-2023 3:05 PM EDT
FDA Approves Minimally Invasive Therapy Shown to Save the Legs of Severe Vascular Disease Patients from Amputation
University Hospitals Cleveland Medical Center

The FDA today announced approval of a therapy giving thousands of patients hope for an alternative to amputation of their legs.

29-Aug-2023 5:55 PM EDT
New study shows promising evidence for sickle cell gene therapy
University of Chicago Medical Center

UChicago Medicine Comer Children’s Hospital was one of three sites to enroll patients in a clinical trial to test a potentially curative stem cell gene therapy for sickle cell disease. The results were promising.

Released: 29-Aug-2023 2:05 PM EDT
Preparing clinicians for the international anti-LGBTQI+ crisis
Boston University School of Medicine

Lesbian, gay, bisexual, transgender, queer, intersex and additional sexual and gender minority (LGBTQI+) people in every region of the world face marginalization and oppression.

Newswise: Optical Coherence Tomography May Improve Safety and Outcomes for Stenting Procedures in Heart Disease Patients Compared to Conventional Angiography
Released: 27-Aug-2023 3:40 AM EDT
Optical Coherence Tomography May Improve Safety and Outcomes for Stenting Procedures in Heart Disease Patients Compared to Conventional Angiography
Mount Sinai Health System

Results from a large-scale clinical trial could increase usage of high resolution imaging for guiding interventional coronary procedures

Released: 25-Aug-2023 4:05 PM EDT
Weight loss medication benefits patients with heart failure and obesity
European Society of Cardiology

Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

Newswise: Adrenocortical carcinoma: No mitotane for low risk of recurrence
Released: 25-Aug-2023 12:50 PM EDT
Adrenocortical carcinoma: No mitotane for low risk of recurrence
University of Würzburg

In 2017, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of Mitotane in the prevention of recurrence in adrenocortical carcinoma.

Not for public release

This news release is embargoed until 16-Aug-2023 5:00 PM EDT Released to reporters: 16-Aug-2023 8:05 AM EDT

A reporter's PressPass is required to access this story until the embargo expires on 16-Aug-2023 5:00 PM EDT The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Released: 16-Aug-2023 12:15 PM EDT
MD Anderson Research Highlights for August 16, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.

   
Newswise: Common Cold Virus Linked to Potentially Fatal Blood Clotting Disorder
Released: 10-Aug-2023 8:00 AM EDT
Common Cold Virus Linked to Potentially Fatal Blood Clotting Disorder
University of North Carolina School of Medicine

The new observation, made by UNC School of Medicine’s Stephan Moll, MD, and Jacquelyn Baskin-Miller, MD, suggests that a life-threatening blood clotting disorder can be caused by an infection with adenovirus, one of the most common respiratory viruses in pediatric and adult patients.

4-Aug-2023 11:50 PM EDT
AI Transformation of Medicine: Why Doctors Are Not Prepared
University of Maryland School of Medicine

As artificial intelligence systems like ChatGPT find their way into everyday use, physicians will start to see these tools incorporated into their clinical practice to help them make important decisions on diagnosis and treatment of common medical conditions.

   
Newswise: Scrambler Therapy May Offer Lasting Relief for Chronic Pain, Review Paper Suggests
Released: 31-Jul-2023 10:30 AM EDT
Scrambler Therapy May Offer Lasting Relief for Chronic Pain, Review Paper Suggests
Johns Hopkins Medicine

A new review paper co-authored by two Johns Hopkins pain experts suggests that scrambler therapy, a noninvasive pain treatment, can yield significant relief for approximately 80%–90% of patients with chronic pain, and it may be more effective than another noninvasive therapy: transcutaneous electrical nerve stimulation (TENS). The write-up was published online July 13 in The New England Journal of Medicine.

Released: 27-Jul-2023 3:15 PM EDT
MIND Diet Study Shows 'Short-Term' Impact on Cognition
RUSH

New research shows the importance of long-term commitment to the MIND diet for reaping the greatest benefit to brain health.

Released: 19-Jul-2023 2:00 PM EDT
ADHD Behind the Wheel: Ways to Keep Teen Drivers Safe
Saint Louis University Medical Center

The summer months are the busiest time on the roads and for teens with ADHD, a new driver’s license carries a lot of responsibility. Saint Louis University (SLU) researcher Annie Artiga Garner, Ph.D., is doing her part to make the roads safer not just for teens with ADHD, but for every driver.

Released: 14-Jul-2023 1:05 PM EDT
Exercise during dialysis has positive health impact
Technical University of Munich

Patients who engage in light exercise while undergoing dialysis are physically fitter and are admitted to hospital less frequently than those who do not.

Released: 6-Jul-2023 6:00 PM EDT
New study: Black women with hypertensive disorders of pregnancy have increased stroke risk
Boston University School of Medicine

U.S. Black women have a disproportionately higher burden of both preeclamptic pregnancy and stroke compared with white women, but virtually all existing evidence on the association between the two medical conditions has come from studies of white women.

Newswise: Study finds new potential therapy option for patients with chronic lymphocytic leukemia
Released: 6-Jul-2023 11:25 AM EDT
Study finds new potential therapy option for patients with chronic lymphocytic leukemia
Ohio State University Wexner Medical Center

Researchers continue to refine and improve targeted drug therapies that have changed the most common form of adult leukemia – from an incurable to a chronic condition. New data published in the New England Journal of Medicine offers another treatment option for patients who have stopped responding to the first and second generation drugs.

Newswise: A new study validates the first-ever predictive AI biomarker of androgen deprivation therapy (ADT) benefit in prostate cancer
Released: 30-Jun-2023 12:20 PM EDT
A new study validates the first-ever predictive AI biomarker of androgen deprivation therapy (ADT) benefit in prostate cancer
University Hospitals Cleveland Medical Center

Data from a new study published in NEJM Evidence shows promise for personalized use of short term ADT in men with predominantly intermediate-risk prostate cancer. The information validates the first-ever predictive AI biomarker of androgen deprivation therapy (ADT) benefit in prostate cancer.

Newswise: Study: Potential New Treatment Identified for Liver Disease
Released: 26-Jun-2023 2:05 PM EDT
Study: Potential New Treatment Identified for Liver Disease
UC San Diego Health

Researchers with UC San Diego School of Medicine identified a potential new drug that improved liver fibrosis in patients with NASH by 27%.

Newswise: Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Released: 22-Jun-2023 1:15 PM EDT
Study Sets New Standard for Graft-Versus-Host Disease Prevention After Stem Cell Transplant
Johns Hopkins Medicine

Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study published in the New England Journal of Medicine. The new standard is more effective at preventing GVHD and came with less side effects, compared with the current gold standard.

Newswise: Study shows video laryngoscope increases successful intubation on first attempt
Released: 16-Jun-2023 10:05 AM EDT
Study shows video laryngoscope increases successful intubation on first attempt
Vanderbilt University Medical Center

A Vanderbilt University Medical Center-led study comparing the two types of laryngoscopes used in tracheal intubation of critically ill patients showed that the use of a video laryngoscope increased successful intubation on the first attempt, compared to the use of a direct laryngoscope, the standard approach for almost a century.

13-Jun-2023 9:00 AM EDT
Major step forward reduces mortality in kidney failure patients
University College London

Mortality in patients with kidney failure has been found to be 23% lower among those treated with high dose haemodiafiltration compared to those treated with high flux haemodialysis, according to new research from the CONVINCE consortium led by University Medical Center Utrecht.

Newswise: Multicenter Trial Finds Using Circulatory Death Donors is Safe and Effective for Heart Transplantation
Released: 7-Jun-2023 6:40 PM EDT
Multicenter Trial Finds Using Circulatory Death Donors is Safe and Effective for Heart Transplantation
Northwestern Medicine

A study published in New England Journal of Medicine confirms that circulatory death donor hearts that are reanimated and perfused with blood outside of the body are as safe and effective to transplant as brain death donor hearts preserved using traditional cold storage. These findings suggest that using hearts donated after circulatory death (DCD) may have the potential to widen the donor pool helping more patients in need of life-saving heart transplants.

Newswise: Study Shows Osimertinib Improves Survival Following Surgery for Non-Small Cell Lung Cancer
Released: 7-Jun-2023 5:20 PM EDT
Study Shows Osimertinib Improves Survival Following Surgery for Non-Small Cell Lung Cancer
Yale Cancer Center/Smilow Cancer Hospital

A new study led by Yale Cancer Center shows improved rates of survival and reduced risk of recurrence in patients with non-small cell lung cancer taking osimertinib (TAGRISSO), a targeted therapy, following surgery. Non-small cell lung cancer (NSCLC), the most common type of lung cancer, tends to recur when diagnosed at advanced stages, which makes treatment challenging.

Newswise: New Heart Transplant Method May Grow Donor Pool 30%
2-Jun-2023 10:00 AM EDT
New Heart Transplant Method May Grow Donor Pool 30%
Duke Health

A study led by Duke Health physicians, appearing online June 8 in the New England Journal of Medicine, found that DCD hearts were equivalent to hearts procured through the current standard of care.

5-Jun-2023 11:25 AM EDT
Devastating heart condition can be reversed, study shows for the first time
University College London

Three men who had heart failure caused by the build-up of sticky, toxic proteins are now free of symptoms after their condition spontaneously reversed in an unprecedented case described by a team at UCL and the Royal Free Hospital.

4-Jun-2023 11:00 AM EDT
ASCO: Axi-cel significantly improves survival in patients with early relapsed or refractory large B-cell lymphoma
University of Texas MD Anderson Cancer Center

Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.



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