Feature Channels: Genetics

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Released: 26-Feb-2024 12:00 PM EST
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
World Journal of Stem Cells

BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune

Newswise: UT Southwestern finds genetic clues to complex infections
Released: 26-Feb-2024 10:05 AM EST
UT Southwestern finds genetic clues to complex infections
UT Southwestern Medical Center

Treating complex bacterial infections with customized therapies tailored to the infection and the patient is closer to reality, thanks to researchers at UT Southwestern Medical Center.

Newswise: A Newborn Genetic Screening Study Reaches New Milestone
Released: 26-Feb-2024 10:05 AM EST
A Newborn Genetic Screening Study Reaches New Milestone
University of North Carolina School of Medicine

A research study named Early Check has screened 1,000 newborns after birth in an effort to help identify rare conditions early, provide treatment, give parents educational information, and connect families with specialists throughout the state of North Carolina.

access_time Embargo lifts in 2 days
This news release is embargoed until 29-Feb-2024 2:00 PM EST Released to reporters: 25-Feb-2024 8:00 PM EST

A reporter's PressPass is required to access this story until the embargo expires on 29-Feb-2024 2:00 PM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Newswise: Markey study shows expanded cancer gene testing feasible, beneficial for patients
Released: 23-Feb-2024 9:05 PM EST
Markey study shows expanded cancer gene testing feasible, beneficial for patients
University of Kentucky

A new University of Kentucky Markey Cancer Center study published in JCO Precision Oncology demonstrates a feasible way to expand germline genetic testing for patients with cancer.

Released: 23-Feb-2024 11:05 AM EST
Genes affect your blood pressure from early childhood
Norwegian University of Science and Technology (NTNU)

Certain genes associated with hypertension affect blood pressure from early in life, and they increase the risk of cardiovascular disease as you get older. However, you can do something about it.

Released: 21-Feb-2024 2:05 PM EST
Long COVID can happen to anyone. Keep up with the latest research on Long COVID on Newswise
Newswise

Stay informed! These are the latest research articles on "Long COVID" from the Coronavirus News Source on Newswise.

Released: 21-Feb-2024 12:00 PM EST
MD Anderson Research Highlights for February 21, 2024
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into drug-drug interactions for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes; patient-derived xenograft models as a viable translational research tool in early-phase clinical trials; a novel gene expression signature to stratify patients with bladder cancer; a potential therapeutic target to overcome treatment resistance in multiple myeloma; a role for mutant p53 in protecting against ferroptosis in triple-negative breast cancer; and diet modifications to improve treatment outcomes in FLT3-mutated AML.

   
Newswise: Weedy rice gets competitive boost from its wild neighbors
19-Feb-2024 8:05 AM EST
Weedy rice gets competitive boost from its wild neighbors
Washington University in St. Louis

Weedy rice is an agricultural pest with a global economic impact. It is an aggressive weed that outcompetes cultivated rice and causes billions of dollars in yield losses worldwide. A study from Washington University in St. Louis offers new insights into genetic changes that give weedy rice its edge over cultivated rice in tropical regions of the world.

Newswise: Genetic insights and conservation challenges of Nara's sacred deer
Released: 21-Feb-2024 3:05 AM EST
Genetic insights and conservation challenges of Nara's sacred deer
Fukushima University

In a world where human activities have left an indelible mark on ecosystems, the preservation of species and natural landscapes has become an urgent global concern.

Newswise: Junk DNA in birds may hold key to safe, efficient gene therapy
Released: 21-Feb-2024 2:05 AM EST
Junk DNA in birds may hold key to safe, efficient gene therapy
University of California, Berkeley

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

   

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This news release is embargoed until 20-Feb-2024 11:00 AM EST Released to reporters: 19-Feb-2024 11:00 AM EST

A reporter's PressPass is required to access this story until the embargo expires on 20-Feb-2024 11:00 AM EST The Newswise PressPass gives verified journalists access to embargoed stories. Please log in to complete a presspass application. If you have not yet registered, please Register. When you fill out the registration form, please identify yourself as a reporter in order to advance to the presspass application form.

Released: 19-Feb-2024 10:05 PM EST
Widely used machine learning models reproduce dataset bias in Rice study
Rice University

High-income communities overrepresented in relevant datasets for immunotherapy research.

   
Released: 19-Feb-2024 8:05 PM EST
Genetic risk prediction for 10 chronic diseases moves closer to the clinic
Broad Institute of MIT and Harvard

As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

Newswise: Newly discovered genetic markers help pinpoint diabetes risks, complications
Released: 19-Feb-2024 7:05 PM EST
Newly discovered genetic markers help pinpoint diabetes risks, complications
University of Massachusetts Amherst

UMass Amherst researcher co-leads worldwide efforts to understand how genetic variants are linked with disease to develop new drugs and treatments.

Newswise: New genetic therapy holds promise for ALS and frontotemporal dementia
Released: 16-Feb-2024 10:05 PM EST
New genetic therapy holds promise for ALS and frontotemporal dementia
Macquarie University

Neuroscientists at Macquarie University in Australia have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice – and may even offer the potential to reverse some of the effects of the fatal diseases.

Newswise: Tawny owl’s pale grey color linked to vital functions ensuring survival in extreme conditions
Released: 14-Feb-2024 11:05 PM EST
Tawny owl’s pale grey color linked to vital functions ensuring survival in extreme conditions
University of Turku (Turun yliopisto)

A recent genetic discovery has revealed that the pale grey plumage of the tawny owl is linked to crucial functions that aid the bird's survival in cold environments.

Newswise: Male fertility gene discovery reveals path to success for sperm
Released: 14-Feb-2024 7:05 PM EST
Male fertility gene discovery reveals path to success for sperm
University of Edinburgh

The discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.

Released: 14-Feb-2024 1:05 PM EST
Key genes linked to DNA damage and human disease uncovered
Wellcome Trust Sanger Institute

Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.

Newswise: Researchers Characterize the Immune Landscape in Cancer
12-Feb-2024 11:05 AM EST
Researchers Characterize the Immune Landscape in Cancer
Mount Sinai Health System

Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February 14 online issue of Cell. Utilizing data from more than 1,000 tumors across 10 different cancers, the study is the first to integrate DNA, RNA, and proteomics (the study of proteins), revealing the complex interplay of immune cells in tumors. The data came from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), a program under the National Cancer Institute.

Newswise: With the help of naked mole rats, Xiao Tian seeks to expose and explain the epigenetic drivers of aging
Released: 14-Feb-2024 8:00 AM EST
With the help of naked mole rats, Xiao Tian seeks to expose and explain the epigenetic drivers of aging
Sanford Burnham Prebys

Xiao Tian, Ph.D., who recently joined Sanford Burnham Prebys as an assistant professor in the Degenerative Diseases Program, focuses on epigenomic changes and deterioration that influence age-related diseases.

Released: 13-Feb-2024 4:25 PM EST
Uncovering insights about prostate cancer risk and genetic ancestry
Argonne National Laboratory

Argonne National Laboratory researchers have made new discoveries about the risks of prostate cancer in people with different genetic backgrounds.

   
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Released: 13-Feb-2024 2:05 PM EST
Cedars-Sinai Guerin Children's Abre Clínica Para el Síndrome de Angelman
Cedars-Sinai

Cedars-Sinai Guerin Children's inauguró hoy una clínica para ofrecer atención multidisciplinar especializada a niños con síndrome de Angelman, una enfermedad del neurodesarrollo rara y grave.

Newswise: 1920_angelman-syndrome-clinic-guerin-childrens-cedars-sinai.jpg?10000
Released: 13-Feb-2024 1:05 PM EST
Cedars-Sinai Guerin Children’s Opens Angelman Syndrome Clinic
Cedars-Sinai

Cedars-Sinai Guerin Children’s opened a clinic today to provide specialized multidisciplinary care for children with Angelman syndrome, a rare and severe neurodevelopmental condition.

Newswise: UT Southwestern collaborates with Pfizer to develop improved RNA delivery technologies
Released: 12-Feb-2024 12:05 PM EST
UT Southwestern collaborates with Pfizer to develop improved RNA delivery technologies
UT Southwestern Medical Center

UT Southwestern Medical Center is partnering with Pfizer Inc. to develop RNA-enhanced delivery technologies for genetic medicine therapies through the Dallas-based medical center's Program in Genetic Drug Engineering.

   
Newswise: Harnessing Human Evolution to Advance Precision Medicine
Released: 9-Feb-2024 3:05 PM EST
Harnessing Human Evolution to Advance Precision Medicine
University of California San Diego

Scientists hope to advance precision medicine through the discovery of a gene variant that leads to the same phenotype in separate high-dwelling populations while taking a different evolutionary path.

7-Feb-2024 2:05 PM EST
Protecting the Protector Boosts Plant Oil Content
Brookhaven National Laboratory

Biologists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have demonstrated a new way to boost the oil content of plant leaves and seeds.

Newswise: New study finds corn genome can gang up on multiple pathogens at once
Released: 7-Feb-2024 11:05 AM EST
New study finds corn genome can gang up on multiple pathogens at once
College of Agricultural, Consumer and Environmental Sciences, University of Illinois Urbana-Champaign

In a changing climate, corn growers need to be ready for anything, including new and shifting disease dynamics. Because it’s impossible to predict which damaging disease will pop up in a given year, corn with resistance to multiple diseases would be a huge win for growers.

Newswise: Epigenetic drift underlies epigenetic clock signals, but…
Released: 6-Feb-2024 5:05 PM EST
Epigenetic drift underlies epigenetic clock signals, but…
Impact Journals LLC

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation.”

Newswise: Building a DNA nanoparticle to be both carrier and medicine
Released: 6-Feb-2024 4:05 PM EST
Building a DNA nanoparticle to be both carrier and medicine
Iowa State University

A pair of Iowa State University geneticists are among the first research teams in the world to construct DNA nanoparticles that can express their own built-in genetic instructions.

Newswise:Video Embedded extra-fingers-and-hearts-pinpointing-changes-to-our-genetic-instructions-that-disrupt-development
VIDEO
Released: 5-Feb-2024 11:00 PM EST
Extra Fingers and Hearts: Pinpointing Changes to Our Genetic Instructions That Disrupt Development
University of California San Diego

Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts.

Newswise: Creating a Virus-Resistant Bacterium Using a Synthetic Engineered Genome
Released: 5-Feb-2024 4:05 PM EST
Creating a Virus-Resistant Bacterium Using a Synthetic Engineered Genome
Department of Energy, Office of Science

To improve bioproducts productivity, researchers have engineered the genome of E. coli to make it immune to viral infections.

   
Newswise: UT Southwestern molecular geneticist wins Hill Prize from TAMEST
Released: 5-Feb-2024 9:30 AM EST
UT Southwestern molecular geneticist wins Hill Prize from TAMEST
UT Southwestern Medical Center

Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research into a key mechanism necessary for cholesterol control.

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Released: 2-Feb-2024 1:55 PM EST
Roswell Park Study Defines Mechanisms Underlying Promising Precision Therapy for Pancreatic Cancer
Roswell Park Comprehensive Cancer Center

A research study led by a multidisciplinary team of scientists at Roswell Park Comprehensive Cancer Center details evidence on the therapeutic efficacy of a compound that targets a key genetic feature of pancreatic cancer.

Released: 2-Feb-2024 11:05 AM EST
Machine learning to battle COVID-19 bacterial co-infection
University of Queensland

University of Queensland researchers have used machine learning to help predict the risk of secondary bacterial infections in hospitalised COVID-19 patients.

Released: 2-Feb-2024 11:05 AM EST
Gene-editing offers hope for people with hereditary disorder
University of Auckland

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

Released: 2-Feb-2024 11:05 AM EST
Identifying genomics markers to predict radiation sensitivity
Université Laval

As the effectiveness of radiotherapy varies greatly between tumours, finding gene signatures to predict the radiation response could better guide the clinicians to personalize treatment plans.

   
Newswise: How Two Sisters Continue to Soar with Sickle Cell Disease
Released: 2-Feb-2024 9:30 AM EST
How Two Sisters Continue to Soar with Sickle Cell Disease
University of North Carolina Health Care System

Sydney and Sheridan Taylor of Durham, North Carolina, have lived with this rare genetic disorder all of their lives.

Released: 1-Feb-2024 10:05 PM EST
Resistant bacteria can remain in the body for years
University of Basel

Fighting disease-causing bacteria becomes more difficult when antibiotics stop working.

Released: 1-Feb-2024 12:05 PM EST
Had COVID-19 But Your Friend Didn’t? Why the Difference?
Cedars-Sinai

Investigators in the Department of Computational Biomedicine at Cedars-Sinai wanted to find out which factors influenced susceptibility to COVID-19 infection and disease severity the most. Was it genetics? Or was it home environment, meaning the germs circulating throughout your everyday life?

Released: 31-Jan-2024 5:05 PM EST
Bringing order to disordered proteins
University of Copenhagen, Faculty of Science

Protein molecules lie at the heart of biology. Our typical understanding of proteins states that each type of protein has a specific three-dimensional shape that enables it to perform its function.

Released: 31-Jan-2024 1:05 PM EST
RNA Scientist Receives Federal Funding to Commercialize Molecular Tool Against Alzheimer’s Disease
University at Albany, State University of New York

University at Albany scientist Scott Tenenbaum, founder of UAlbany spinoff company sxRNA Technologies, Inc. (sxRNA Tech), has received $500,000 from the National Institute on Aging, part of the National Institutes of Health, to study how aging brain cells shape the progression of Alzheimer’s disease, and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer's and related dementias.

Released: 31-Jan-2024 12:05 PM EST
Groundbreaking genome editing tools unlock new possibilities for precision medicine
Technische Universität Dresden

Traditional genome editing faced limitations in achieving ultimate precision until now. Prof. Buchholz's team has broken through this barrier by creating what many have sought after: a zinc-finger conditioned recombinase.

Newswise: Mapeamento dos comportamentos celulares em glioma de alto grau para a melhora do tratamento
Released: 31-Jan-2024 11:05 AM EST
Mapeamento dos comportamentos celulares em glioma de alto grau para a melhora do tratamento
Mayo Clinic

Gliomas de alto grau são tumores cancerígenos que se espalham rapidamente no cérebro ou na medula espinhal.

Newswise: وضع خريطة لسلوكيات خلايا الورم الدِبقي عالي الدرجة لتحسين العلاج
Released: 31-Jan-2024 11:05 AM EST
وضع خريطة لسلوكيات خلايا الورم الدِبقي عالي الدرجة لتحسين العلاج
Mayo Clinic

الأورام الدبقية عالية الدرجة هي أورام سرطانية تنتشر بسرعة في الدماغ أو الحبل النخاعي. في دراسة جديدة أجريت تحت إشراف مايو كلينك، وجد الباحثون أن هوامش أورام الدماغ الغزوية للورم الدبقي عالي الدرجة تحتوي على تغيرات جينية وجزيئية مميزة بيولوجيًا تشير إلى السلوك العدواني وتكرار المرض. وتُظهر النتائج تصورات متعمقة للعلاجات المحتملة التي يمكن أن تحوّل مسار المرض.

Newswise: Mapeo de los comportamientos celulares en glioma de alto grado para la mejora del tratamiento
Released: 31-Jan-2024 11:05 AM EST
Mapeo de los comportamientos celulares en glioma de alto grado para la mejora del tratamiento
Mayo Clinic

Los gliomas de alto grado son tumores cancerígenos que se propagan rápidamente en el cerebro o en la médula espinal.

Released: 30-Jan-2024 1:05 PM EST
DNA particles that mimic viruses hold promise as vaccines
Massachusetts Institute of Technology (MIT)

Using a virus-like delivery particle made from DNA, researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have created a vaccine that can induce a strong antibody response against SARS-CoV-2.

Newswise: University Hospitals Selected as Study Site for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) Study
Released: 30-Jan-2024 9:30 AM EST
University Hospitals Selected as Study Site for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) Study
University Hospitals Cleveland Medical Center

University Hospitals has been selected by the Global Parkinson’s Genetics Program as one of four new study sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) study.

Newswise: RNA sequencing analysis may hold the key to more accurate diagnosis and targeted treatment of pediatric B-acute lymphoblastic leukemia
Released: 29-Jan-2024 12:05 PM EST
RNA sequencing analysis may hold the key to more accurate diagnosis and targeted treatment of pediatric B-acute lymphoblastic leukemia
Elsevier

Pilot study by Children’s Hospital Los Angeles and City of Hope proposes a promising global, clinically applicable genomic assay for the diagnosis and treatment of this heterogeneous leukemia, reports The Journal of Molecular Diagnostics.



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