Curated News: JAMA

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The ARCADIA study was a multicenter, double-blind, randomized clinical trial conducted between 2017 and 2020.

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A research team exploring how genes and environmental factors interact in psychiatry has discovered that a history of sexual trauma and a genetic tendency to develop mental illness are associated with increased risk for schizophrenia, bipolar disorder and major depression.

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A novel combination therapy slowed cognitive decline in elderly patients with a history of depression – a major risk factor for developing Alzheimer’s and other forms of dementia, a study led by UT Southwestern Medical Center’s new Chair and Professor of Psychiatry found.

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The EVOLVED trial found that early aortic valve intervention in patients with asymptomatic severe aortic stenosis (AS) and mid-wall myocardial fibrosis on magnetic resonance imaging did not reduce the incidence of the composite primary endpoint of all-cause death or unplanned aortic stenosis hospitalization compared with guideline-directed conservative management. Findings were reported today at TCT 2024, the annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. The results were also published simultaneously in the Journal of the American Medical Association.

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A recent publication in JAMA Network Open helps to shed light on the quality of life and health outcomes among adults with congenital heart disease (CHD) through critical findings from the Congenital Heart Initiative (CHI) registry. Ochsner Health pediatric cardiologist and adult congenital heart specialist, Thomas Young, MD, is a contributing author for the publication.

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A new study found that higher levels of stereotypical male gender expression were associated with a decrease in reported diagnoses and treatment for cardiovascular disease risk factors.

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Researchers from The University of Texas MD Anderson Cancer Center demonstrated that anti-PD-L1 immunotherapy in combination with mutation-directed targeted therapy extended overall survival (OS) in patients with anaplastic thyroid carcinoma (ATC).

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Breast cancer takes a major toll on Caribbean women. They are often diagnosed at a younger age than women in the U.S., and have one of the highest mortality rates worldwide. A new study in JAMA Network Open suggests that these higher rates may be linked to shifting patterns in reproductive health.

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It affects as many as one in 10 people assigned female at birth, and is associated with an increased risk for a few other serious health conditions.

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Expanded treatment options, increased naloxone distribution and targeted education campaigns likely led to a 37% reduction in overdose deaths from opioids combined with stimulant drugs other than cocaine, according to the results of a large federally funded study.

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U.S. babies died at a higher rate in the months following the Supreme Court’s 2022 Dobbs v. Jackson Women’s Health decision, and infant mortality was highest among those born with chromosomal or genetic abnormalities, new research has found.

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In a peer-reviewed study believed to be the first of its kind published, a research team led by Johns Hopkins Medicine provides scientific evidence that a healthy diet may reduce the chance of low risk prostate cancer progressing to a more aggressive state in men undergoing active surveillance — a clinical option in which men with lower risk cancer are carefully monitored for progression in lieu of treatments that could have undesired side effects or complications.

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A new study, conducted by a group of researchers led by Penn Nursing and Perelman School of Medicine and funded by the Centers for Disease Control, found a strong association between handheld cellphone use and risky driving behaviors among newly licensed teen drivers. The study, published online first in JAMA Open, used a smartphone telematics application to track the driving habits of hundreds of teens and identify potential safety risks.

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A study led by Adam Rodman, MD, MPH, Director of AI Programs at Beth Israel Deaconess Medical Center (BIDMC), reveals that, rather than helping to reduce racial and ethnic biases, AI-driven chatbots may instead perpetuate and exacerbate disparities in medicine.

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Despite having no greater chance of developing problems after high risk cardiovascular surgery, women are more likely than men to die from postoperative complications, a University of Michigan-led study suggests. The quality of a hospital where the procedure was performed did not affect the disparity between sexes. Researchers say the "failure to rescue" is an issue for the entire United States health care system.

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Medicare could save up to 74% of the money lost from discarded Alzheimer’s drug lecanemab by the simple introduction of a new vial size that would reduce the amount of unused medication that is thrown away.

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In a new, large comprehensive analysis led by the American Cancer Society (ACS), researchers, using a form of Artificial Intelligence (AI), found that more than one-third of fundraising stories on the GoFundMe crowdfunding platform in the United States explicitly shared experiences of medical financial hardships and health-related social needs

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Injuries and substance abuse are leading causes of adolescent deaths. Screening adolescents for substance use can reduce the risk of future drug and alcohol use and reinjury. But how are clinicians deciding who to screen?

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Investigators say failing to follow arm support guidelines during BP screening could have significant clinical impact

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Injured adolescents from marginalized groups treated at pediatric trauma centers are more likely to be tested for drugs and alcohol than white adolescents, even when accounting for injury severity.