Credit: The American Journal of Pathology
Confocal images of human monocytes immunostained with antibodies toward SHARPIN (red) and caspase 1 (green). Notice the dramatic increase in caspase 1 upon stimulation with lipopolysaccharide (LPS) and ATP, and its co-localization with SHARPIN as visualized by the merged fluorescence (yellow). Nuclei are stained blue with DAPI.