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  • Two independent pathways enable taste cells to sense sweet-tasting compounds. The T1R pathway detects both caloric (eg, glucose, sucrose) and non-caloric (eg, saccharin, sucralose) sweet molecules. The T1R-independent 'secondary' pathway senses simple caloric sugars such as glucose and fructose. Disaccharide enzymes in the sweet taste cells break down complex dietary sugars and starch by-products into simple sugars that can activate both pathways.
    Karen Yee, Monell Center. Attribution required. Permission required for modification
    Two independent pathways enable taste cells to sense sweet-tasting compounds. The T1R pathway detects both caloric (eg, glucose, sucrose) and non-caloric (eg, saccharin, sucralose) sweet molecules. The T1R-independent 'secondary' pathway senses simple caloric sugars such as glucose and fructose. Disaccharide enzymes in the sweet taste cells break down complex dietary sugars and starch by-products into simple sugars that can activate both pathways.
  • Taste cells, identified by presence of T1R (green), also contain the enzyme sucrase (red), which cleaves sucrose into the simple sugars glucose and fructose, which can be detected by both sugar-sensing pathways.
    Karen Yee, Monell Center. Attribution required. Permission required for modification
    Taste cells, identified by presence of T1R (green), also contain the enzyme sucrase (red), which cleaves sucrose into the simple sugars glucose and fructose, which can be detected by both sugar-sensing pathways.
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