Credit:
Reprogramming the wound interface augments dense connective tissue repair. Water-soluble poly(ethylene oxide) (PEO) nanofibers (green) release a matrix-degrading enzyme (X) in a burst fashion over 24 hours, loosening the surrounding matrix and enabling cell migration from the wound matrix to the defect. Controlled release of a chemoattractant (filled black circle) from hyaluronic acid (HA) nanofibers (blue) over 5 weeks recruits additional cells to the interface and into the scaffold. Dissolution of PEO fibers and degradation of HA fibers result in a highly porous scaffold composed of slow-degrading poly(ε-caprolactone) (PCL) nanofibers (red).