Credit: Parikh
(A) MDA-MB-231 (aggressive breast cancer cells) form epithelial-like structures (structure of the cells that incline toward to healthy tissues) with reduced aggressiveness on softer surfaces, but with increase in stiffness/rigidity the cells become more aggressive, lose their capabilities to form colony (intermediate) and with stiff surfaces they tend to become more aggressive as the area of the cell decreases.
(B) MCF-7 (localized breast cancer cells) form colonies and are less aggressive on softer surfaces, while on intermediate surfaces, the size of the colony reduces, the cells become comparatively aggressive and on stiff surfaces, they lose the capacity to form colonies and are highly aggressive.