Credit: The Li laboratory, UT Southwestern
Cryo-EM structures illuminate the molecular mechanism of Hedgehog signaling. 1. PTCH1 alone. 2. 1-to-1 ratio PTCH1-HH complex (Nature 560:128-132). 3. 2-to-1 ratio PTCH1-HH complex (Science doi/10.1126/science.aas8843).