Credit: Moffitt Cancer Center
o perform a spatial ecological analysis the team developed a new tool called VALIS that aligns histology slides, making it possible to construct highly multiplexed images from tissues stained via immunohistochemistry (IHC) and/or immunofluorescence. This image shows one of the 11-plex IHC used in the spatial analysis, which revealed that progressed adenomas reside in an immunosuppressive niche.