Credit: Modified from Goff, J.L., et al., Mixed heavy metal stress induces global iron starvation response. The ISME Journal (2022). The original image is licensed under a Creative Commons Attribution 4.0 International License
Left: the subsurface at the Oak Ridge Reservation has high levels of multiple metals, affecting growth & metabolism of native bacteria. Right: proteomic response to metal exposures. Lines connect exposure conditions (white circles) to individual proteins.