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Promising target for CAR T cells helps cancer trick the immune system

Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for relapsed and recurrent pediatric leukemia and lymphomas, but not brain and solid tumors.
21-Nov-2023 11:05 AM EST Add to Favorites

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Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia

Scientists at St. Jude Children’s Research Hospital mapped the difference in chromatin accessibility and regulation in different pediatric acute lymphoblastic leukemia subtypes.
20-Nov-2023 10:05 AM EST Add to Favorites

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Fusion oncoprotein forces cell fates toward rhabdomyosarcoma

Scientists at St. Jude Children’s Research Hospital showed that a fusion oncoprotein can drive molecularly indistinguishable rhabdomyosarcomas arising from both muscle and blood vessel cells.
15-Nov-2023 12:05 PM EST Add to Favorites

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St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing

St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes...
15-Nov-2023 11:05 AM EST Add to Favorites

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Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital

He has also become co-leader of the Neurobiology and Brain Tumor Program within the St. Jude Comprehensive Cancer Center. These combined units comprise one of the largest clinical brain tumor programs in North America.
7-Nov-2023 10:00 AM EST Add to Favorites

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Scientists reveal structures of neurotransmitter transporter

Scientists at St. Jude Children’s Research Hospital determined structures of a transporter protein involved in the movement of neurochemicals such as serotonin and dopamine, unearthing multiple mechanisms that can guide drug development.
30-Oct-2023 1:05 PM EDT Add to Favorites

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St. Jude Children’s Research Hospital, ALSAC Announce New Board Leaders

St. Jude Children’s Research Hospital and ALSAC, its fundraising and awareness organization, announced new leaders of the St. Jude Board of Governors and ALSAC Board of Directors today. The announcement comes at a time when St. Jude is advancing...
16-Oct-2023 10:00 AM EDT Add to Favorites

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3D genome architecture influences SCID-X1 gene therapy success

In 2019, St. Jude lentiviral gene therapy restored the immune system in multiple infants of X-linked severe combined immunodeficiency disorder (SCID-X1) or “bubble boy disease” at the DNA level. These children can now produce functional immune...
6-Oct-2023 2:05 PM EDT Add to Favorites

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The mission of St. Jude Children’s Research Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.



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