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To respond or tolerate? LJI researchers selectively block immune activation program orchestrated by the nuclear factor NFAT

The immune system occasionally makes mistakes that require correction. For example, in autoimmunity, T-cells lose "immune tolerance" of self and can destroy one's very own tissues. Conversely, in cancer, the immune system can rapidly exhaust itself...
22-Apr-2019 3:05 PM EDT Add to Favorites

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Why your kid’s strep throat keeps coming back

Each year, some 600 million people around the world come down with strep throat. Yet, it was unclear why some kids are prone to repeated bouts of strep throat while others appear to be more or less immune. The latest study by researchers at La Jolla...
4-Feb-2019 7:00 AM EST Add to Favorites

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La Jolla Institute Awarded Renewal of NIH Contract to Continue Its Role as Host of Immune Epitope Database

La Jolla Institute for Immunology (LJI) has been awarded a $22 million contract renewal over seven years from the National Institutes of Health (NIH) to host and expand the Immune Epitope Database (IEDB). The database is the world’s most...
23-Jan-2019 4:05 PM EST Add to Favorites

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La Jolla Institute for Immunology renews longtime collaboration with Kyowa Kirin Pharmaceutical Research, Inc.

La Jolla Institute for Immunology (LJI) and Kyowa Kirin Pharmaceutical Research, Inc. (KKR), a wholly-owned subsidiary of Kyowa Hakko Kirin Co., Ltd. (KHK), a global specialty pharmaceutical company, today announced the signing of a new agreement. ...
18-Dec-2018 5:05 PM EST Add to Favorites

DICE: Immune cell atlas goes live

For more than four years, a team of LJI scientists led by Associate Professor Pandurangan Vijayanand, M.D., Ph.D., has been undertaking a massive immunoprofiling effort, detailing how variations in DNA sequence impact gene activity in different...
12-Nov-2018 12:05 PM EST Add to Favorites

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Maternally-Acquired Zika Immunity Can Increase Dengue Disease Severity in Mouse Pups

In this study, La Jolla Institute for Immunology (LJI) investigator Sujan Shresta, Ph.D., who studies both dengue and Zika viruses, explored awhether maternal immunity to Zika virus, which is structurally and genetically similar to dengue, might...
8-Nov-2018 5:05 PM EST Add to Favorites

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Global immunoprofiling effort reveals multifunctional T cell response during Zika infection

The latest study by researchers at the La Jolla Institute for Immunology (LJI) and their collaborators provide the first in-depth characterization of the body’s cytotoxic T cell response to Zika, which plays an important role in providing...
13-Nov-2018 11:05 AM EST Add to Favorites

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LJI investigators discover how protein pair controls cellular calcium signals

Two studies recently published by La Jolla Institute for Immunology (LJI) investigators Patrick Hogan, PhD, and Aparna Gudlur, PhD, report how a calcium-sensing protein called STIM1 signals that it's time to initiate calcium retrieval and then...
26-Oct-2018 1:35 PM EDT Add to Favorites


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Our Experts on Newswise

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Dr. Matthias von Herrath named world’s leading type 1 diabetes expert

Dr. Matthias von Herrath, M.D., who founded the Type 1 Diabetes Center at La Jolla Institute for Immunology (LJI) has been identified as the world’s top expert in Type 1 Diabetes by Expertscape, an organization that provides tools to quickly and...
12-Dec-2018 11:05 AM EST

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About

The La Jolla Institute for Immunology is dedicated to increasing knowledge and improving human health through studies of the immune system. Our essential purpose is to expand our understanding of how the immune system works and to discover the causes of immune system disorders. The knowledge gained through our biomedical research can, in turn lead to the prevention, treatment and cure of a wide range of human diseases.

Experts

  • Klaus Ley

    Professor

    Keywords:
    Inflammation, Heart Disease, Vaccine, chronic inflammation, Integrins
     
     
  • Pandurangan Vijayanand

    William K. Bowes Distinguished Professor

    Keywords:
    Asthma, PrecISE Clinical Center, Lung Cancer, immune fitness, immune profiling, Precision Medicine, genomic tools
     
     
  • Catherine Hedrick

    Professor

    Keywords:
    Monocytes, Cancer, Cardiovascular Disease, T Lymphocytes, cancer metastasis, Heart Disease, Plaques, Immune Cells
     
     
  • Shane Crotty

    Professor

    Keywords:
    Hiv Vaccine, human immune response, Vaccines, CHAVI-ID, Germinal Centers, neutralizing antibodies
     
     
  • Michael Croft

    Professor

    Keywords:
    Fibrosis, Atopic Dermatitis, Asthma, Eczema, Tumor Necrosis Factor, TNF, Inflammation, Light, TNF family, Autoimmune Disease, Psoriasis
     
     

Contacts

Gina Kirchweger
Chief Communications Officer
allergy immunology

gina@lji.org

858-752-6640

Jenna Hambrick
Digital Strategist

jhambrick@lji.org

858.752.6645

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