La Jolla Institute for Allergy and Immunology
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Novel Genomic Tools Provide New Insight Into Human Immune System

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La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.
19-Jan-2018 2:00 PM EST Add to Favorites

LJI Researchers Discover Key Driver of Atopic Dermatitis

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La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the...
16-Jan-2018 5:05 PM EST Add to Favorites

One in a Million

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The development of an HIV vaccine has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are exceedingly rare within the average human....
20-Dec-2017 12:00 AM EST Add to Favorites

LJI Researchers Report How T Cells Navigate the Rough-and-Tumble Environment of the Bloodstream

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Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these...
20-Dec-2017 12:05 PM EST Add to Favorites

San Diego Team Wins $ 6.9 Million Grant to Establish PrecISE Network Clinical Center

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A team of physicians, scientists and biostatisticians from La Jolla Institute for Allergy and Immunology and UC San Diego School of Medicine joined forces across institutions to successfully compete for an $6.9 million grant to establish one of only...
6-Dec-2017 11:05 AM EST Add to Favorites

Allergy Amplifier Implicated in Asthma Also Intensifies Food Allergy

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In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF...
9-Nov-2017 4:05 PM EST Add to Favorites

Dengue Immunity Can Protect Against Zika Virus

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A study by LJI researcher Dr. Sujan Shresta reports that mice rendered immune to dengue show "cross-protection" from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. These...
9-Nov-2017 5:00 AM EST Add to Favorites

No Longer Lost in Translation

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Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses. As a result, insights gained in the lab may be lost in translation. In...
26-Jul-2017 5:05 PM EDT Add to Favorites

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