La Jolla Institute for Allergy and Immunology
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La Jolla, CA USA

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Novel Genomic Tools Provide New Insight Into Human Immune System


La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.
19-Jan-2018 2:00 PM EST Add to Favorites

LJI Researchers Discover Key Driver of Atopic Dermatitis


La Jolla Institute scientists demonstrate that LIGHT, a member of the tumor necrosis factor (TNF) super family, directly controls the hyperproliferation of keratinocytes as well as the expression of periostin, a protein that contributes to the...
16-Jan-2018 5:05 PM EST Add to Favorites

One in a Million


The development of an HIV vaccine has proven extraordinarily difficult. One of the reasons is that naïve precursor B cells that can give rise to mature B cells producing broadly neutralizing antibodies are exceedingly rare within the average human....
20-Dec-2017 12:00 AM EST Add to Favorites

LJI Researchers Report How T Cells Navigate the Rough-and-Tumble Environment of the Bloodstream


Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, the team shows that immature T cells lack these...
20-Dec-2017 12:05 PM EST Add to Favorites

San Diego Team Wins $ 6.9 Million Grant to Establish PrecISE Network Clinical Center


A team of physicians, scientists and biostatisticians from La Jolla Institute for Allergy and Immunology and UC San Diego School of Medicine joined forces across institutions to successfully compete for an $6.9 million grant to establish one of only...
6-Dec-2017 11:05 AM EST Add to Favorites

Allergy Amplifier Implicated in Asthma Also Intensifies Food Allergy


In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF...
9-Nov-2017 4:05 PM EST Add to Favorites

Dengue Immunity Can Protect Against Zika Virus


A study by LJI researcher Dr. Sujan Shresta reports that mice rendered immune to dengue show "cross-protection" from subsequent Zika infection and then identifies specific types of immune T-cells capable of defending against both viruses. These...
9-Nov-2017 5:00 AM EST Add to Favorites

No Longer Lost in Translation


Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses. As a result, insights gained in the lab may be lost in translation. In...
26-Jul-2017 5:05 PM EDT Add to Favorites

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