La Jolla Institute for Allergy and Immunology
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Genetic Deletion of Two Protein-Modifying Enzymes Predisposes Mice to Asthma

Allergic asthma is a chronic inflammatory disease of the lung and airways driven, at least in part, by, a subgroup of overly active T helper cells. Thus, to devise better treatments, it is essential to determine how this cell population, known as...
19-Jun-2018 12:05 PM EDT Add to Favorites


LJI Researchers Are One Step Closer to an Effective Anti-Atherosclerosis Vaccine

A new paper published in Circulation by researchers at La Jolla Institute for Allergy and Immunology reports successful vaccination of atherosclerotic mice with a small chunk of protein snipped out of "bad cholesterol." Vaccination reduced plaque...
12-Apr-2018 12:05 PM EDT Add to Favorites


Bystander T Cells Can Steal the Show From "Professional" Regulatory Cells in Resolving Inflammation

A team led by LJI researchers reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. This is noteworthy because that chief anti-inflammatory role has been traditionally...
19-Mar-2018 11:05 AM EDT Add to Favorites


Western Diet Depletes Artery-Protecting Immune Cells

New research from scientists at the La Jolla Institute for Allergy and Immunology shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate...
20-Mar-2018 6:05 PM EDT Add to Favorites


Immune Signature Predicts Asthma Susceptibility

Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of...
16-Feb-2018 10:05 AM EST Add to Favorites


LJI researchers reveal how to undermine immune cell mobilization in allergic inflammation.

LJI researchers report mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response. These discoveries suggest a novel approach to treat inflammatory disease caused by...
9-Feb-2018 11:05 AM EST Add to Favorites


Groundbreaking Parkinson’s Research at La Jolla Institute Funded by Michael J. Fox Foundation

La Jolla Institute Professor Dr. Alessandro Sette has been awarded a $340,000 grant by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to follow up on an earlier MJFF-supported study, which provided the strongest evidence to date...
23-Jan-2018 11:05 AM EST Add to Favorites


Novel Genomic Tools Provide New Insight Into Human Immune System

La Jolla Institute scientists provide new insights into how so-called CD4 cytotoxic T cells arise in humans and thus could facilitate improved vaccine design.
19-Jan-2018 2:00 PM EST Add to Favorites

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