La Jolla Institute for Allergy and Immunology
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Researchers Find Elusive Source of Most Abundant Immune Cell

Neutrophils—short-lived, highly mobile and versatile—outnumber all other immune cells circulating through the blood stream. Now, researchers at La Jolla Institute for Allergy and Immunology identified a progenitor of neutrophils in the bone...
24-Aug-2018 11:35 AM EDT Add to Favorites

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Innate Lymphoid Cells (ILCs) form an essential line of defense against enteric bacteria

Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the...
6-Aug-2018 11:05 AM EDT Add to Favorites

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Maternal Dengue Immunity Protects Against Fetal Damage in Mice Following Zika Virus Infection

A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of...
30-Jul-2018 1:15 PM EDT Add to Favorites

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Kimishige Ishizaka, Distinguished Immunologist Who Guided Growth of Nascent La Jolla Institute, Dies

Dr. Kimishige Ishizaka, discoverer of a novel class of antibodies and the first Scientific Director of the La Jolla Institute for Allergy and Immunology (LJI), has died on July 6 in Yamagata City, Japan. He was 92 years old.
9-Jul-2018 4:30 PM EDT Add to Favorites

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Genetic Deletion of Two Protein-Modifying Enzymes Predisposes Mice to Asthma

Allergic asthma is a chronic inflammatory disease of the lung and airways driven, at least in part, by, a subgroup of overly active T helper cells. Thus, to devise better treatments, it is essential to determine how this cell population, known as...
19-Jun-2018 12:05 PM EDT Add to Favorites

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LJI Researchers Are One Step Closer to an Effective Anti-Atherosclerosis Vaccine

A new paper published in Circulation by researchers at La Jolla Institute for Allergy and Immunology reports successful vaccination of atherosclerotic mice with a small chunk of protein snipped out of "bad cholesterol." Vaccination reduced plaque...
12-Apr-2018 12:05 PM EDT Add to Favorites

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Bystander T Cells Can Steal the Show From "Professional" Regulatory Cells in Resolving Inflammation

A team led by LJI researchers reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. This is noteworthy because that chief anti-inflammatory role has been traditionally...
19-Mar-2018 11:05 AM EDT Add to Favorites

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Western Diet Depletes Artery-Protecting Immune Cells

New research from scientists at the La Jolla Institute for Allergy and Immunology shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate...
20-Mar-2018 6:05 PM EDT Add to Favorites


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About

The La Jolla Institute for Allergy & Immunology is dedicated to increasing knowledge and improving human health through studies of the immune system. Our essential purpose is to expand our understanding of how the immune system works and to discover the causes of immune system disorders. The knowledge gained through our biomedical research can, in turn lead to the prevention, treatment and cure of a wide range of human diseases.

Experts

  • Klaus Ley

    Professor

    Keywords:
    Inflammation, Heart Disease, Vaccine, chronic inflammation, Integrins
     
     
  • Pandurangan Vijayanand

    William K. Bowes Distinguished Professor

    Keywords:
    Asthma, PrecISE Clinical Center, Lung Cancer, immune fitness, immune profiling, Precision Medicine, genomic tools
     
     
  • Catherine Hedrick

    Professor

    Keywords:
    Monocytes, Cancer, Cardiovascular Disease, T Lymphocytes, cancer metastasis, Heart Disease, Plaques, Immune Cells
     
     
  • Shane Crotty

    Professor

    Keywords:
    Hiv Vaccine, human immune response, Vaccines, CHAVI-ID, Germinal Centers, neutralizing antibodies
     
     
  • Michael Croft

    Professor

    Keywords:
    Fibrosis, Atopic Dermatitis, Asthma, Eczema, Tumor Necrosis Factor, TNF, Inflammation, Light, TNF family, Autoimmune Disease, Psoriasis
     
     

Contacts

Gina Kirchweger
Chief Communications Officer
allergy immunology

858-752-6640

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