Jeffrey  Tessem, PhD

Jeffrey Tessem, PhD

American Physiological Society (APS)

Assistant Professor of Nutrition, Dietetics and Food Science - Brigham Young University.

Expertise: Diabetes

Biography
Dr. Tessem received his Bachelors degree in Microbiology from Brigham Young University in 2001 and his Ph.D. in Biochemistry and Molecular Biology from the University of Colorado Health Sciences Center in 2007. Dr. Tessem completed a post-doctoral fellowship with Christopher Newgard at the Duke University Medical Center's Sarah W. Stedman Center for Nutrition and Metabolism Research.

Research Interests
Both Type 1 (T1D) and Type 2 diabetes (T2D) are caused by a relative insufficiency in functional β-cell mass. Current therapeutic options for diabetes include daily insulin injections to maintain normoglycemia, pharmacological agents to stimulate β-cell function and enhance insulin sensitivity, or islet transplantation. A major obstacle to greater application of islet transplantation therapy is the scarcity of human islets. Thus, new methods for expansion of β-cell mass, applied in vitro to generate the large numbers of human islet cells needed for transplantation, or in situ to induce expansion of the patients remaining β-cells, could have broad therapeutic implications for this disease. To this end, our lab is interested in delineating the molecular pathways that increase β-cell proliferation, enhance glucose stimulated insulin secretion, and protect against β-cell death.

Teaching Interests
My teaching interests focus on nutrient metabolism and biochemistry. I am interested in the metabolic disorders that cause human diseases.


Title

Cited By

Year

Stimulation of human and rat islet β-cell proliferation with retention of function by the homeodomain transcription factor Nkx6. 1

116

2008

The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss

90

2003

Nkx6. 1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

75

2014

Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders

69

2016

Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration

52

2008

Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration

38

2017

Function of Nr4a orphan nuclear receptors in proliferation, apoptosis and fuel utilization across tissues

31

2019

Aurora Kinase A is critical for the Nkx6. 1 mediated β-cell proliferation pathway

31

2015

Nkx6. 1‐mediated insulin secretion and β‐cell proliferation is dependent on upregulation of c‐Fos

26

2016

β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion

24

2016

Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells

23

2018

β-Hydroxybutyrate elicits favorable mitochondrial changes in skeletal muscle

20

2018

Acylation of superoxide dismutase 1 (SOD1) at K122 governs SOD1-mediated inhibition of mitochondrial respiration

19

2017

Cdk5r1 overexpression induces primary β-cell proliferation

17

2016

Roles for bone-marrow-derived cells in β-cell maintenance

11

2004

High-resolution respirometry to measure mitochondrial function of intact beta cells in the presence of natural compounds

5

2018

β-Hydroxybutyrate improves β-cell mitochondrial function and survival

5

2017

Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass

4

2020

HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27

4

2018

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ …

3

2021

Physiologists Celebrate 100 Years of Insulin

This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life.
30-Oct-2021 08:05:43 AM EDT

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