For years doctors have debated whether the progressively destructive course of genetic heart disease is due principally to the altered genes that set it in motion, or to the body's ceaseless efforts to compensate for and cope with the initial damage.
A search for the genetic roots of towering height has led a Johns Hopkins endocrinologist to identify a mutation that causes a rare form of treatable dwarfism. Research results, published in the March issue of the Journal of Clinical Endocrinology and Metabolism, suggest that the mutation could be used as a prenatal screening test for the disorder.
Nearly 90 percent of prostate cancers -- "the typical, garden varieties," according to Johns Hopkins scientists -- are linked to a previously unsuspected but common genetic process that could be reversible. The process looks to be a fundamental one in cancer and appears in other common forms of the disease, like breast cancer.
One of the nation's leading authorities on threats to the public's health and the man credited with the success of the smallpox eradication project a quarter century ago, says the virus is once again a threat to the United States and the world -- this time as a weapon of bioterrorists.
A voluntary, emergency department-based program to test patients' blood for HIV was well accepted at Johns Hopkins, as about half the patients approached consented. Study results were published in the February issue of the Annals of Emergency Medicine.
With the help of fruit flies and jellyfish, Johns Hopkins scientists have proved they can quiet firing nerve cells -- at least temporarily -- by inserting the genetic version of an off switch.
Researchers at Johns Hopkins in Baltimore and the National Zoo in Washington, D.C., have discovered the cause of death of nearly a dozen young North American zoo elephants -- fatal hemorrhaging from a previously unknown form of herpesvirus that apparently jumped from African elephants to the Asian species.
A team of neuroscientists at Johns Hopkins offers the first concrete evidence of what's behind some of the most incapacitating pain syndromes people can suffer.
A strict low-protein diet for chronic kidney failure patients can delay dialysis treatment for about a year, according to results of a Johns Hopkins study.
With weapons of biological and chemical terrorism in the headlines and firmly on the nation's public agenda, political leaders, physicians, research scientists, as well as law enforcement and intelligence experts will meet Feb. 16 and 17 at the Crystal Gateway Marriott to talk about what to do should bioterrorists launch an assault on civilians in the United States.
Using a library of almost 1,000 skull bones collected for more than 30 years at the Johns Hopkins Medical Institutions, researchers have identified a consistent congenital basis for a rare but troubling disorder they discovered in which loud noises cause dizziness. Their findings are to be presented Feb. 17 at the Association for Research in Otolaryngology (ARO) meeting in St. Petersburg Beach, Fla.
Scientists from Johns Hopkins and two Israeli universities have discovered another likely benefit of the much-touted legume, soybeans: They may bring pain relief. A new study shows that laboratory rats fed a diet containing soy meal develop far less pain after nerve injury than their counterparts on soy-free diets.
A widely used nonsurgical treatment for rapid heart rhythms is safe and beneficial for both children and adults, according to results of a national study led by Johns Hopkins physicians.
Scientists at Johns Hopkins and in India report they have sequenced the complete genome of a form of HIV, the AIDS virus, from that country for the first time. The work has revealed unexpected variation in genes for one key part of the virus, prompting the researchers to suggest that currently favored approaches to vaccine development may not work.
1- low-dose radiation may keep arteries clear after angioplasty, 2- if your sibling has heart disease, you might be at risk, 3- mortality rates from abdominal aneurysms declining, 4- heart transplant recipients need to watch their diets.
Researchers at the Johns Hopkins Oncology Center used high doses of the chemotherapy drug cyclophosphamide alone to control previously untreatable forms of autoimmune disorders such as rheumatoid arthritis, lupus and hemolytic anemia.
A study at Johns Hopkins suggests a new way to safely and effectively detect thyroid cells left-over after cancer therapy.
Cases of life-threatening heart muscle inflammation are declining in the United States, mirroring a decline in enteroviral infections that often lead to the inflammation, according to a Johns Hopkins study.
More than half of a group of children surveyed by Johns Hopkins get too many of their daily calories from fat, according to a new study. Ten percent of the children exceed the daily recommended levels of cholesterol.
Environmental stressors contribute significantly to hypertension in young, urban African-American males, but high blood pressure can be dramatically decreased with the intervention of health care providers, researchers at Johns Hopkins University School of Nursing report.
If President Clinton had known what a pair of Johns Hopkins doctors recently learned from two patients with a temporary form of amnesia, charges that he lied about sex might be moot.
A team of scientists has isolated and identified human stem cells and proved them capable of forming the fundamental tissues that give rise to distinct human cells such as muscle, bone and nerve. This feat has for decades been one of basic science's holy grails, and while scientists have found stem cells in mice and higher animals, this is believed to be the first time researchers have cultured human embryonic stem cells.
Johns Hopkins scientists have found a genetic alteration associated with common forms of colon cancer in patients' normal cells. The same abnormality, called loss of imprinting (LOI), also appears, the researchers say, in a significant number of healthy people, offering a possibility of predicting as many as 40 percent of new colon cancer cases before they start.
The common street drug "ecstasy" causes brain damage in people, according to a new Johns Hopkins study. In a report in The Lancet released this week, Hopkins scientists show that the drug -- known chemically as MDMA -- damages specific nerves in the brain that release serotonin, the nerve transmitter thought to play a role in regulating mood, memory, pain perception, sleep, appetite and sexual activity.
Scientists now can predict, with 99 percent accuracy, carriers of the gene for adrenoleukodystrophy (ALD), the disease featured in the movie "Lorenzo's Oil." The new procedure developed at Johns Hopkins -- DNA carrier-based testing -- directly analyzes a woman's genes for specific mutations.
The tiniest blood vessels nourishing the heart are at risk of damage not only during a heart attack but also after normal blood flow returns through the region, a Johns Hopkins-led animal study has found.
Maryland surgeons who perform the greatest number of thyroidectomies have the lowest complication rates, according to results of a statewide study by Johns Hopkins researchers published in the September 1998 issue of Annals of Surgery.
At a ceremony today, the Johns Hopkins Children's Center will dedicate the first pediatric research center designed to pinpoint links between severe mental illness and early childhood viral infections. The 4th Symposium on the Neurovirology and Neuroimmunology of Schizophrenia and Bipolar Disorder will be held November 4-7, 1998 at the Bethesda Marriott Hotel.
Women subjected to "low-severity" violence -- shoves, grabs or threats from someone they love -- are more likely to suffer physical and psychological health problems than women in more peaceful relationships, a Johns Hopkins study has found.
Johns Hopkins researchers, collaborating with an international team of geneticists, have pinpointed the site of the first gene for a major cancer located on the human X chromosome.
Biochemists at Johns Hopkins report they have solved a major mystery surrounding the way most organisms -- including people -- get energy. Their discovery, in this month's Proceedings of the National Academy of Sciences,caps decades of research on how cells make the common currency of energy, a molecule called ATP.
A recent multicenter trial shows a natural factor that encourages nerve growth may bring relief from one of the more common effects of HIV infection: sensory neuropathy. The study, led by Johns Hopkins researchers, is supported by the AIDS Clinical Trials Group at the National Institutes of Health.
Nearly one in 10 female new recruits in the Army is infected with Chlamydia trachomatis, according to a study reported in today's New England Journal of Medicine.
In the latest of a series of discoveries about colon cancer genes, researchers at the Johns Hopkins Oncology Center and the Howard Hughes Medical Institute have discovered a connection between two of them, APC and c-MYC, that conspires to initiate almost all colon cancers. Their findings are reported in the September 4, 1998, issue of SCIENCE.
Researchers at the Johns Hopkins Bayview Medical Center have found that inexpensive signs can encourage stair use, as reported in the September issue of the Annals of Internal Medicine.
A 15-year study in more than 100 families and 1,000 subjects provides the first reliable evidence of genetic susceptibility to schizophrenia, within a stretch of DNA on human chromosome 13, according to a Johns Hopkins-led international team.
Exposure to sunlight increases risk of getting cataracts, according to a Johns Hopkins study.
Shame, denial and fear of others' reactions keep many abused women from confiding in their physicians, a Johns Hopkins study among Baltimore women has found.
All sexually active adolescent females should be tested by family doctors not once but twice a year for chlamydia infection, a significant preventable cause of pelvic inflammatory disease and infertility in women in the United States, say Johns Hopkins researchers.
Researchers at Johns Hopkins School of Nursing and other institutions report that nearly 4 in 10 female emergency room patients have been victims of physical or emotional domestic abuse sometime in their lives, and 14 percent have been physically or sexually abused in the past year.
The Johns Hopkins School of Public Health, in collaboration with the Hopkins Oncology Center, has received a five-year, $3.8 million grant from the National Cancer Institute (NCI) to establish an innovative cancer genetics network in the Mid-Atlantic region.
Researchers at Johns Hopkins School of Nursing and other institutions report that nearly 4 in 10 female emergency room patients have been victims of physical or emotional domestic abuse sometime in their lives, and 14 percent have been physically or sexually abused in the past year.
Men with clinical depression are more than twice as likely to develop coronary artery disease (CAD) as their non-depressed counterparts, a Johns Hopkins study has shown.
A move in Maryland toward regionalization -- centralizing particular medical services at centers performing the greatest number -- decreased the death rates for one of the most complex operations for cancer, according to a study by Johns Hopkins researchers published in the July 7, 1998 issue of Annals of Surgery.
New data presented at the 12th World AIDS Conference in Geneva show that untreated anemia alone can significantly increase the risk of death in people with HIV/AIDS.
Laboratory studies at Johns Hopkins have dramatically confirmed the power of a chemical discovered from the liver of sharks to slow the formation of new blood vessels destined to feed brain cancers as well as other tumors.
Researchers at Johns Hopkins have come one step closer to understanding the chain of events that protects the heart against injury during a heart attack, paving the way for the development of a new class of drugs to treat people at risk.
Some anesthesiologists may be accidentally inhaling too much of the potent anesthetic gas halothane when they tend to their patients, possibly putting themselves at high risk for liver injury, according to a study by researchers at Johns Hopkins and the National Institutes of Health.
The largest, most comprehensive genome-wide study of patients with inflammatory bowel disease (IBD) -- including Crohn's disease and ulcerative colitis -- has focused and narrowed the search for the genes that cause this common and debilitating illness, a team of researchers from the University of Chicago Medical Center, Johns Hopkins Medical Institutions, and the Marshfield Medical Research Foundation in Marshfield, Wisconsin, report in the June 23 issue of the Proceedings of the National Academy of Scientists.
Johns Hopkins researchers have found evidence that Tourette's syndrome, which causes involuntary muscle contractions and bursts of words and noise, may be triggered in part by an infection.
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